CD301b+ macrophage: the new booster for activating bone regeneration in periodontitis treatment - PMC
Journal
International journal of oral science
α-Ketoglutaric acid ameliorates hyperglycemia in diabetes by inhibiting hepatic gluconeogenesis via serpina1e signaling
LYC inhibits the AKT signaling pathway to activate autophagy and ameliorate TGFB-induced renal fibrosis
lncRNA SNHG11 promotes gastric cancer progression by activating the Wnt/β-catenin pathway and oncogenic autophagy
Journal
Molecular therapy : the journal of the American Society of Gene Therapy
The role of the LncRNA-FA2H-2-MLKL pathway in atherosclerosis by regulation of autophagy flux and inflammation through mTOR-dependent signaling.
Journal
Cell death and differentiation
Modified CFBP-bFGF targeting to ischemic brain promoted the functional recovery of cerebral ischemia
Journal
Journal of controlled release : official journal of the Controlled Release Society
Enho Mutations Causing Low Adropin: A Possible Pathomechanism of MPO-ANCA Associated Lung Injury.
Value added immunoregulatory polysaccharides of Hericium erinaceus and their effect on the gut microbiota
Nontoxic concentration of ochratoxin A decreases the dosage of cyclosporine A to induce chronic nephropathy model via autophagy mediated by toll-like receptor 4
Journal
Cell Death & Disease
CALCB splice region pathogenic variants leading to plasma cell neurotropic enrichment in type 1 autoimmune pancreatitis
Journal
Cell death & disease
Exogenous l-Valine Promotes Phagocytosis to Kill Multidrug-Resistant Bacterial Pathogens
Journal
Frontiers in immunology
CD58 acts as a tumor promotor in hepatocellular carcinoma via activating the AKT/GSK-3/-catenin pathway - PMC
Journal
Journal of translational medicine
LncRNA NORAD Mediates the Proliferation and Apoptosis of Diffuse Large-B-Cell Lymphoma via Regulation of miR-345-3p/TRAF6 Axis
Journal
Archives of medical research
GL-V9 exerts anti-T cell malignancies effects via promoting lysosome-dependent AKT1 degradation and activating AKT1/FOXO3A/BIM axis.
Journal
Free radical biology & medicine
Species
Homo sapiens, Mus musculus
Anti-melanogenesis of novel kojic acid derivatives in B16F10 cells and zebrafish.
Journal
International journal of biological macromolecules
CXCL12 has therapeutic value in facial nerve injury and promotes Schwann cells autophagy and migration via PI3K-AKT-mTOR signal pathway.
Journal
International journal of biological macromolecules
Picornavirus infection enhances aspartate by the SLC38A8 transporter to promote viral replication - PMC
A small molecule targeting CHI3L1 inhibits lung metastasis by blocking IL‐13Rα2‐mediated JNK‐AP‐1 signals
Journal
Molecular oncology
DJ-1/FGFR-1 Signaling Pathway Contributes to Sorafenib Resistance in Hepatocellular Carcinoma - PMC
Journal
Oxidative medicine and cellular longevity
Brexpiprazole caused glycolipid metabolic disorder by inhibiting GLP1/GLP1R signaling in rats
Journal
Acta Pharmacol Sin
FGF19 promotes nasopharyngeal carcinoma progression by inducing angiogenesis via inhibiting TRIM21-mediated ANXA2 ubiquitination
Journal
Cellular oncology (Dordrecht)
Activation of the CD200/CD200R1 axis attenuates neuroinflammation and improves postoperative cognitive dysfunction via the PI3K/Akt/NF-B signaling pathway in
Journal
Inflammation research : official journal of the European Histamine Research Society ... [et al.]
Research and experimental verification of the molecular mechanism of berberine in improving premature ovarian failure based on network pharmacology
Gigantol inhibits proliferation and enhances DDP-induced apoptosis in breast-cancer cells by downregulating the PI3K/Akt/mTOR signaling pathway
Schisantherin A causes endothelium-dependent and -independent vasorelaxation in isolated rat thoracic aorta
Effects and Mechanisms of Rhus chinensis Mill. Fruits on Suppressing RANKL-Induced Osteoclastogenesis by Network Pharmacology and Validation in RAW264.7 Cells
Apocynum venetum leaf extract alleviated doxorubicin-induced cardiotoxicity through the AKT/Bcl-2 signaling pathway
Species
Apocynum venetum leaf
Overexpression of GATA5 Inhibits Prostate Cancer Progression by Regulating PLAGL2 via the FAK/PI3K/AKT Pathway
Increased Expression of Integrin Alpha 6 in Nucleus Pulposus Cells in Response to High Oxygen Tension Protects against Intervertebral Disc Degeneration
Journal
Oxid Med Cell Longev
Long noncoding RNA TCL6 binds to miR‐106a‐5p to regulate hepatocellular carcinoma cells through PI3K/AKT signaling pathway
Journal
Journal of cellular physiology
Loss of PR55α promotes proliferation and metastasis by activating MAPK/AKT signaling in hepatocellular carcinoma
Ganoderic acid improves 5-fluorouracil-induced cognitive dysfunction in mice
Isoviolanthin Extracted from Dendrobium officinale Reverses TGF-β1-Mediated Epithelial⁻Mesenchymal Transition in Hepatocellular Carcinoma Cells via Deactivating the TGF-β/Smad and PI3K/Akt/mTOR Signaling Pathways.
Journal
International Journal of Molecular Sciences
Vaccarin Regulates Diabetic Chronic Wound Healing through FOXP2/AGGF1 Pathways
Journal
International Journal of Molecular Sciences
HSPA5 Promotes the Proliferation, Metastasis and Regulates Ferroptosis of Bladder Cancer - PMC
Journal
International journal of molecular sciences
Diclofenac Sensitizes Signet Ring Cell Gastric Carcinoma Cells to Cisplatin by Activating Autophagy and Inhibition of Survival Signal Pathways - PMC
Journal
International journal of molecular sciences
Ketogenic Diet Alleviates Renal Interstitial Fibrosis in UUO Mice by Regulating Macrophage Proliferation
Journal
The Journal of nutritional biochemistry
SHIP1 Activator AQX-1125 Regulates Osteogenesis and Osteoclastogenesis Through PI3K/Akt and NF-κb Signaling
Journal
Frontiers in cell and developmental biology
WTD Attenuating Rheumatoid Arthritis via Suppressing Angiogenesis and Modulating the PI3K/AKT/mTOR/HIF-1α Pathway
Hydroxy--sanshool isolated from Zanthoxylum bungeanum Maxim. has antidiabetic effects on high-fat-fed and streptozotocin-treated mice via increasing glycogen synthesis by regulation of PI3K/Akt/GSK-3/GS signaling - PMC
Journal
Frontiers in pharmacology
Species
Homo sapiens, Mus musculus
Alpiniae oxyphyllae fructus possesses neuroprotective effects on H2O2 stimulated PC12 cells via regulation of the PI3K/Akt signaling Pathway - PMC
Journal
Frontiers in pharmacology
EGCG protects the mouse brain against cerebral ischemia/reperfusion injury by suppressing autophagy via the AKT/AMPK/mTOR phosphorylation pathway - PMC
Journal
Frontiers in pharmacology
Monomethyl lithospermate alleviates ischemic stroke injury in middle cerebral artery occlusion mice in vivo and protects oxygen glucose deprivation/reoxygenation induced SHSY-5Y cells in vitro via activation of PI3K/Akt signaling - PMC
Journal
Frontiers in pharmacology
ZNF139/circZNF139 promotes cell proliferation, migration and invasion via activation of PI3K/AKT pathway in bladder cancer
Mannan Oligosaccharide Could Attenuate Ochratoxin A-Induced Immunosuppression with Long-Time Exposure Instead of Immunostimulation with Short-Time …
Species
Mannan Oligosaccharide
Acetate Upregulates GPR43 Expression and Function via PI3K-AKT-SP1 Signaling in Mammary Epithelial Cells during Milk Fat Synthesis
Journal
Journal of agricultural and food chemistry
Toosendanin suppresses oncogenic phenotypes of human gastric carcinoma SGC?7901 cells partly via miR?200a?mediated downregulation of β-catenin pathway
Journal
International Journal of Oncology
VEZF1, destabilized by STUB1, affects cellular growth and metastasis of hepatocellular carcinoma by transcriptionally regulating PAQR4
Journal
Cancer gene therapy
Agrin Promotes Non-Small Cell Lung Cancer Progression and Stimulates Regulatory T Cells via Increasing IL-6 Secretion Through PI3K/AKT Pathway
Journal
Frontiers in oncology
Species
Homo sapiens, Mus musculus
Human SP-D Acts as an Innate Immune Surveillance Molecule Against Androgen-Responsive and Androgen-Resistant Prostate Cancer Cells
Journal
Frontiers in Oncology
Impaired airway epithelial barrier integrity was mediated by PI3K in a mouse model of lipopolysaccharide-induced acute lung injury
Journal
Int Immunopharmacol
Genipin attenuates mitochondrial-dependent apoptosis, endoplasmic reticulum stress, and inflammation via the PI3K/AKT pathway in acute lung injury.
Journal
International immunopharmacology
pNaktide mitigates inflammation-induced neuronal damage and behavioral deficits through the oxidative stress pathway
Journal
International immunopharmacology
Ameliorative effects of eosinophil deficiency on immune response, endoplasmic reticulum stress, apoptosis, and autophagy in fungus-induced allergic lung inflammation
Prenatal EGCG exposure-induced heart mass reduction in adult male mice and underlying mechanisms
Glycolysis inhibition and apoptosis induction in human prostate cancer cells by FV-429-mediated regulation of AR-AKT-HK2 signaling network
Theabrownin Isolated from Pu-Erh Tea Enhances the Innate Immune and Anti-Inflammatory Effects of RAW264.7 Macrophages via the TLR2/4-Mediated Signaling Pathway - PMC
Journal
Foods (Basel, Switzerland)
Attenuated Salmonella engineered with an apoptosis-inducing factor (AIF) eukaryotic expressing system enhances its anti-tumor effect in melanoma in vitro and in vivo
Journal
Applied Microbiology and Biotechnology
A novel combination of sitagliptin and melatonin ameliorates T2D manifestations: studies on experimental diabetic models
Journal
Journal of endocrinological investigation
SNORA23 inhibits HCC tumorigenesis by impairing the 2′-O-ribose methylation level of 28S rRNA
Journal
Cancer biology & medicine
Glycyrrhizin regulates rat TMJOA progression by inhibiting the HMGB1‐RAGE/TLR4‐NF‐κB/AKT pathway
Journal
Journal of cellular and molecular medicine
Aloe vera mitigates dextran sulfate sodium-induced rat ulcerative colitis by potentiating colon mucus barrier
Loureirin B attenuates insulin resistance in HepG2 cells by regulating gluconeogenesis signaling pathway
The mechanism of action of safflower total flavonoids in the treatment of endometritis caused by incomplete abortion based on network pharmacology and 16S rDNA …
Journal
Journal of ethnopharmacology
Regulation of Microcystin-LR-Induced DNA Damage by miR-451a in HL7702 Cells.
Effects of miR-101-3p on goat granulosa cells in vitro and ovarian development in vivo via STC1
Journal
J Anim Sci Biotechnol
HTRA3 transcriptionally inhibited by FOXP1 suppresses tumorigenesis of osteosarcoma via the PTEN/PI3K/AKT pathway
Journal
Biochimica et biophysica acta. Molecular cell research
When "No-Smoking" is not enough: Hypoxia and nicotine acetylcholine receptor signaling may drive lung adenocarcinoma progression in never-smokers
Journal
Biochimica et biophysica acta. Molecular cell research
Structure Identification of ViceninII Extracted from Dendrobium officinale and the Reversal of TGF-β1-Induced Epithelial?Mesenchymal Transition in Lung Adenocarcinoma Cells through TGF-β/Smad and PI3K/Akt/mTOR Signaling Pathways.
Species
Dendrobium officinale Kimura et Migo
Corneal denervation causes epithelial apoptosis through inhibiting NAD+ biosynthesis
Journal
Investigative ophthalmology & visual science
Confusoside from Anneslea fragrans Alleviates Acetaminophen-Induced Liver Injury in HepG2 via PI3K-CASP3 Signaling Pathway - PMC
Journal
Molecules (Basel, Switzerland)
Phosphatidylinositol 3-Kinase Mediates -Catenin Dysfunction of Airway Epithelium in a Toluene Diisocyanate-Induced Murine Asthma Model
Journal
Toxicological sciences
Ganoderma triterpenes Protect Against Hyperhomocysteinemia Induced Endothelial-Mesenchymal Transition via TGF- Signaling Inhibition.
Journal
Frontiers in Physiology
GSTP1 Inhibits LPS-Induced Inflammatory Response Through Regulating Autophagy in THP-1 Cells
Cr(VI)-Induced Autophagy Protects L-02 Hepatocytes from Apoptosis Through the ROS-AKT-mTOR Pathway.
Journal
Cellular physiology and biochemistry
Legumain Inhibitor Prevents Breast Cancer Bone Metastasis by Attenuating Osteoclast Differentiation and Function
Species
Homo sapiens, Mus musculus
PSMD1 and PSMD2 regulate HepG2 cell proliferation and apoptosis via modulating cellular lipid droplet metabolism
Journal
BMC Molecular Biology
Exosomes derived from autologous dermal fibroblasts promote diabetic cutaneous wound healing through the Akt/-catenin pathway
Long noncoding RNA STXBP5-AS1 inhibits cell proliferation, migration, and invasion via preventing the PI3K/AKT against STXBP5 expression in non-small-cell lung carcinoma.
Journal
Journal of cellular biochemistry
dCas9guided demethylation of the AKT1 promoter improves milk protein synthesis in a bovine mastitis mammary gland epithelial model induced by using
Journal
Cell biology international
Long Noncoding RNA ADAMTS9-AS2 Inhibits the Proliferation, Migration, and Invasion in Bladder Tumor Cells
Lamin B1 Overexpresses in Lung Adenocarcinoma and Promotes Proliferation in Lung Cancer Cells via AKT Pathway
Journal
Oncotargets and Therapy
Long noncoding RNA STXBP5-AS1 inhibits cell proliferation, migration, and invasion through inhibiting the PI3K/AKT signaling pathway in gastric cancer cells.
Journal
OncoTargets and therapy
Traditional Chinese medicine Astragalus polysaccharide enhanced antitumor effects of the angiogenesis inhibitor apatinib in pancreatic cancer cells on proliferation, invasiveness, and apoptosis
Journal
OncoTargets and therapy
Loganin Attenuates Septic Acute Renal Injury with the Participation of AKT and Nrf2/HO-1 Signaling Pathways
Journal
Drug Des Devel Ther
Mechanism of M2 macrophages modulating astrocyte polarization through the TGF-β/PI3K/Akt pathway
Journal
Immunology letters
Berberine exerts its antineoplastic effects by reversing the Warburg effect via downregulation of the Akt/mTOR/GLUT1 signaling pathway
Overexpressed lncRNA FTX promotes the cell viability, proliferation, migration and invasion of renal cell carcinoma via FTX/miR-4429/UBE2C axis - PMC
Species
Homo sapiens, Mus musculus
A comparative study unraveling the effects of TNF-α stimulation on endothelial cells between 2D and 3D culture
The UC-MSCbFGF/scaffold system accelerates the healing of the uterine full-thickness injury
Journal
Tissue engineering. Part A
Ligusticum chuanxiong promotes the angiogenesis of preovulatory follicles (F1-F3) in late-phase laying hens
Combination of zinc and selenium alleviates ochratoxin A-induced fibrosis via blocking ROS-dependent autophagy in HK-2 cells
Journal
J Trace Elem Med Biol
Long non-coding RNA ADAMTS9-AS1 exacerbates cell proliferation, migration, and invasion via triggering of the PI3K/AKT/mTOR pathway in hepatocellular …
Majoon chobchini reinstates PDL-1 expression and blocks dendritic cell-T helper 17 pathogenic axis in rheumatoid arthritis animal model
An investigation into the mechanism of nobiletin's inhibition of papillary thyroid cancer using network pharmacology analysis and experimental pharmacology
Journal
European review for medical and pharmacological sciences
Baicalin attenuates pulmonary vascular remodeling by inhibiting calpain-1 mediated endothelial-to-mesenchymal transition - PMC
MicroRNA-30c-5p ameliorates hypoxia-reoxygenation-induced tubular epithelial cell injury via HIF1α stabilization by targeting SOCS3
The Anti-Apoptotic Role of COX-2 during In Vitro Infection of Human Intestinal Cell Line by Giardia duodenalis and The Potential Regulators
Journal
Infection and immunity
Schisandra chinensis acidic polysaccharide partialy reverses acetaminophen-induced liver injury in mice
Journal
Journal of pharmacological sciences
Qing Zao Fang (QZF) Alleviates the Inflammatory Microenvironment of the Submandibular Gland in Sjögren's Syndrome Based on the PI3K/Akt/HIF-1 α /VEGF Signaling Pathway
Umbilical cord-derived mesenchymal stem cells alleviated inflammation and inhibited apoptosis in interstitial cystitis via AKT/mTOR signaling pathway
Journal
Biochemical And Biophysical Research Communications
LncRNA LINC00511 promotes COL1A1-mediated proliferation and metastasis by sponging miR-126-5p/miR-218-5p in lung adenocarcinoma - PMC
Journal
BMC pulmonary medicine
Repurposing Pitavastatin and L-Glutamine: Replenishing β-Cells in Hyperlipidemic Type 2 Diabetes Mouse Model - PMC
Journal
Life (Basel, Switzerland)
Ginsenoside Rg3 Suppresses Proliferation and Induces Apoptosis in Human Osteosarcoma
Journal
BioMed Research International
Dandelion root extract protects NCM460 colonic cells and relieves experimental mouse colitis
Journal
Journal of Natural Medicines
DEPDC1B promotes migration and invasion in pancreatic ductal adenocarcinoma by activating the Akt/GSK3尾/Snail pathway
Matrine induces apoptosis in acute myeloid leukemia cells by inhibiting the PI3K/Akt/mTOR signaling pathway.
ZnSO4 Protects against premature ovarian failure through PI3K/AKT/GSK3β signaling pathway
Gefitinib represses JAK-STAT signaling activated by CRTC1-MAML2 fusion in mucoepidermoid carcinoma cells
Journal
Current cancer drug targets
Long non-coding RNA ADAMTS9-AS2 inhibits liver cancer cell proliferation, migration and invasion
Angelica Yinzi Alleviates Pruritus-Related Atopic Dermatitis through Skin Repair, Antioxidation, and Balancing Peripheral μ- and -opioid Receptors - PMC
Journal
Evidence-based complementary and alternative medicine : eCAM
Schisandra Chinensis Acidic Polysaccharide Improves the Insulin Resistance in Type 2 Diabetic Rats by Inhibiting Inflammation
Journal
Journal of Medicinal Food
Metformin mediated microRNA-7 upregulation inhibits growth, migration, and invasion of non-small cell lung cancer A549 cells
Pou2F3 silencing enhanced the proliferation of mammary epithelial cells in dairy goat via PI3K/AKT/mTOR signaling pathway
ChemR23 activation attenuates cognitive impairment in chronic cerebral hypoperfusion by inhibiting NLRP3 inflammasome-induced neuronal pyroptosis - PMC
Journal
Cell death & disease
Species
Rattus norvegicus, Homo sapiens
Matrine inhibits proliferation and promotes autophagy and apoptosis in non-small cell lung cancer cells by deactivating PI3K/AKT/mTOR pathway
Journal
Nan fang yi ke da xue xue bao = Journal of Southern Medical University
Dapagliflozin aggravates renal injury via promoting gluconeogenesis in db/db mice
Journal
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology