APC Rabbit anti-Human CD154/CD40L mAb (A28809)

CD40 ligand (CD40L), also known as CD154, TRAP and gp39, is a ligand of the TNF receptor family member CD40. CD40L is expressed as a soluble cytokine or as an heterotrimeric transmembrane protein. CD40L is mainly expressed on the surface of T cells, but has also been found in blood platelets, mast cells, basophils, NK cells, and B cells. It plays an important role in stimulating B cell proliferation and survival, as well as promoting immunoglobulin class switching and IgE secretion. The signal generated by CD40 varies according to the cell type, including activation of the MAPK pathway and NF-κB. Mutations within the CD40L gene are associated with X-linked IgM hyperactivity syndrome, which is characterized by high serum IgM levels and decreased levels of other isotypes. The CD40L/CD40 pathway is an important area of research in cancer, vascular diseases, and inflammatory disorders.