Methyltransferase like 7B is a potential therapeutic target for reversing EGFR-TKIs resistance in lung adenocarcinoma
Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes - PMC
Journal
Signal transduction and targeted therapy
Engineering and Characterization of an Artificial Drugcarrying Vesicles Nanoplatform for Enhanced Specifically Targeted Therapy of Glioblastoma
Journal
Advanced materials (Deerfield Beach, Fla.)
A viral movement protein targets host catalases for 26S proteasome-mediated degradation to facilitate viral infection and aphid transmission in wheat
Species
Arabidopsis thaliana,Triticum aestivum
SHP-1 inhibition targets leukaemia stem cells to restore immunosurveillance and enhance chemosensitivity by metabolic reprogramming
Journal
Nature cell biology
FBXO34 promotes latent HIV-1 activation by post-transcriptional modulation
Journal
Emerging microbes & infections
Smad3 methylation by EZH2 promotes its activation and tumor metastasis
Journal
The Journal of clinical investigation
ADAR1 links R-loop homeostasis to ATR activation in replication stress response
Journal
Nucleic acids research
Structural basis of the subcortical maternal complex and its implications in reproductive disorders
Journal
Nature structural & molecular biology
PHGDH arginine methylation by PRMT1 promotes serine synthesis and represents a therapeutic vulnerability in hepatocellular carcinoma - PMC
Journal
Nature communications
Mechanism of hormone and allosteric agonist mediated activation of follicle stimulating hormone receptor - PMC
Journal
Nature communications
Phosphorylation of SWEET sucrose transporters regulates plant root: shoot ratio under drought
Species
Arabidopsis thaliana
NU6300 covalently reacts with cysteine-191 of gasdermin D to block its cleavage and palmitoylation - PMC
PD-L1 methylation restricts PD-L1/PD-1 interactions to control cancer immune surveillance - PMC
SMYD2 inhibition-mediated hypomethylation of Ku70 contributes to impaired nonhomologous end joining repair and antitumor immunity - PMC
Periplocin suppresses the growth of colorectal cancer cells by triggering LGALS3 (galectin 3)-mediated lysophagy
miR156a-targeted SBP-Box transcription factor SlSPL13 regulates inflorescence morphogenesis by directly activating SFT in tomato
Journal
Plant Biotechnology Journal
Species
Arabidopsis thaliana
A novel method for silkworm cocoons self-degumming and its effect on silk fibers
Journal
Journal of advanced research
Species
Bombyx mori Linnaeus
FIBP interacts with transcription factor STAT3 to induce EME1 expression and drive radioresistance in lung adenocarcinoma - PMC
Journal
International journal of biological sciences
Stk24 protects against obesity-associated metabolic disorders by disrupting the NLRP3 inflammasome
Species
Homo sapiens, Mus musculus
USP7 mediates pathological hepatic de novo lipogenesis through promoting stabilization and transcription of ZNF638
Species
Homo sapiens, Mus musculus
The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages - PMC
Journal
Cell death & disease
Identification of novel GPCR partners of the central melanocortin signaling
N-Acetyl-l-cysteine restores reproductive defects caused by Ggt1 deletion in mice
RIPK3-MLKL necroptotic signalling amplifies STING pathway and exacerbates lethal sepsis - PMC
Journal
Clinical and translational medicine
MBD3 promotes epithelial-mesenchymal transition in gastric cancer cells by upregulating ACTG1 via the PI3K/AKT pathway - PMC
Journal
Biological procedures online
ECHS1 suppresses renal cell carcinoma development through inhibiting mTOR signaling activation
Journal
Biomedicine & Pharmacotherapy
Circ_000829 Plays an Anticancer Role in Renal Cell Carcinoma by Suppressing SRSF1-Mediated Alternative Splicing of SLC39A14 - PMC
Journal
Oxidative medicine and cellular longevity
Acetylation stabilizes stathmin1 and promotes its activity contributing to gallbladder cancer metastasis
Journal
Cell death discovery
Nuclear transport factor GmNTF2B‐1 enhances soybean drought tolerance by interacting with oxidoreductase GmOXR17 to reduce reactive oxygen species content
Journal
The Plant journal : for cell and molecular biology
Aberrant Expression of Mitochondrial SAM Transporter SLC25A26 Impairs Oocyte Maturation and Early Development in Mice
Journal
Oxidative medicine and cellular longevity
DYNLT1 promotes mitochondrial metabolism to fuel breast cancer development by inhibiting ubiquitination degradation of VDAC1 - PMC
Journal
Molecular medicine (Cambridge, Mass.)
ARHGAP11A Is a Novel Prognostic and Predictive Biomarker Correlated with Immunosuppressive Microenvironment in Clear Cell Renal Cell Carcinoma - PMC
Journal
International journal of molecular sciences
GDPD5 Related to Lipid Metabolism Is a Potential Prognostic Biomarker in Neuroblastoma - PMC
Journal
International journal of molecular sciences
Identification and characterization of the CDK1-BMAL1-UHRF1 pathway driving tumor progression - PMC
Functional Characterization of the Internal Symmetry of MRAP2 Antiparallel Homodimer
Journal
Front Endocrinol (Lausanne)
Trametinib alleviates lipopolysaccharide-induced acute lung injury by inhibiting the MEK-ERK-Egr-1 pathway
Journal
International Immunopharmacology
LIM and Cysteine-Rich Domains 1 Promotes Transforming Growth Factor 1Induced EpithelialMesenchymal Transition in Human Kidney 2 Cells
Journal
Laboratory investigation; a journal of technical methods and pathology
The Japanese Encephalitis Virus NS1' Protein Inhibits Type I IFN Production by Targeting MAVS
Journal
Journal of Immunology (Baltimore, Md. : 1950)
E3 ubiquitin ligase RNF180 impairs IPO4/SOX2 complex stability and inhibits SOX2-mediated malignancy in ovarian cancer
Journal
Cellular signalling
GSTP1 Inhibits LPS-Induced Inflammatory Response Through Regulating Autophagy in THP-1 Cells
A novel homozygous variant in NLRP5 is associate with human early embryonic arrest in a consanguineous Chinese family
MUC16 C-terminal binding with ALDOC disrupts the ability of ALDOC to sense glucose and promotes gallbladder carcinoma growth
Inhibition of 14-3-3 by K50 acetylation activates YAP1 to promote cholangiocarcinoma growth
Journal
Experimental cell research
Selenoprotein S regulates tumorigenesis of clear cell renal cell carcinoma through AKT/ GSK3β/NF-κB signaling pathway
Carboxyl-terminal polypeptide fragment of MUC16 combing stathmin1 promotes gallbladder cancer cell migration and invasion
ERBB2 S310F mutation independently activates PI3K/AKT and MAPK pathways through homodimers to contribute gallbladder carcinoma growth
Journal
Medical oncology (Northwood, London, England)
YAP confers resistance to vandetanib in medullary thyroid cancer
Journal
Biochemistry and cell biology = Biochimie et biologie cellulaire
KRAS G12D mutation eliminates reactive oxygen species through the Nrf2/CSE/H2S axis and contributes to pancreatic cancer growth - PMC
Journal
Acta biochimica et biophysica Sinica
BMX activates Wnt/β-catenin signaling pathway to promote cell proliferation and migration in breast cancer
Journal
Breast Cancer (Tokyo, Japan)
Pharmacological modulation of melanocortin-4 receptor by melanocortin receptor accessory protein 2 in Nile tilapia.
Journal
General and comparative endocrinology
Species
Oreochroms mossambcus
Toxoplasma gondii rhoptry protein (TgROP18) enhances the expression of pro-inflammatory factor in LPS/IFN--induced murine BV2 microglia cells via NF-B signal
ABHD7-mediated depalmitoylation of lamin A promotes myoblast differentiation
Species
Homo sapiens,Mus musculus
Feedback loop regulation between viperin and viral hemorrhagic septicemia virus through competing protein degradation pathways - PMC
Journal
bioRxiv : the preprint server for biology
B4GALT1 promotes immune escape by regulating the expression of PD-L1 at multiple levels in lung adenocarcinoma - PMC
Journal
Journal of experimental & clinical cancer research : CR
APOBEC3B coordinates R-loop to promote replication stress and sensitize cancer cells to ATR/Chk1 inhibitors - PMC
Journal
Cell death & disease
Numb/Parkin-directed mitochondrial fitness governs cancer cell fate via metabolic regulation of histone lactylation
Improving the circulation time and renal therapeutic potency of extracellular vesicles using an endogenous ligand binding strategy