Smad3 methylation by EZH2 promotes its activation and tumor metastasis
Journal
The Journal of clinical investigation
Breast cancer cell-derived extracellular vesicles promote CD8+T cell exhaustion via TGF- type II receptor signaling - PMC
Journal
Nature communications
Polystyrene nanoplastics induce cardiotoxicity by upregulating HIPK2 and activating the P53 and TGF-1/Smad3 pathways
Journal
Journal of hazardous materials
Inhibition of HIPK2 protects stress-induced pathological cardiac remodeling - PMC
Nebulized milk exosomes loaded with siTGF-1 ameliorate pulmonary fibrosis by inhibiting EMT pathway and enhancing collagen permeability - PMC
Journal
Journal of nanobiotechnology
Role of RNA m6A modification in titanium dioxide nanoparticle-induced acute pulmonary injury: An in vitro and in vivo study
Journal
Environmental pollution (Barking, Essex : 1987)
Alternative polyadenylation trans-factor FIP1 exacerbates UUO/IRI-induced kidney injury and contributes to AKI-CKD transition via ROS-NLRP3 axis
Therapeutic potency of compound RMY-205 for pulmonary fibrosis induced by SARS-CoV-2 nucleocapsid protein - PMC
Journal
Cell chemical biology
Species
Homo sapiens, Mus musculus
Sinomenine Relieves Airway Remodeling By Inhibiting Epithelial-Mesenchymal Transition Through Downregulating TGF-β1 and Smad3 Expression In Vitro and In Vivo
Paris polyphylla ethanol extract and polyphyllin I ameliorate adenomyosis by inhibiting epithelialmesenchymal transition
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Follistatin Is a Novel Chemoattractant for Migration and Invasion of Placental Trophoblasts of Mice - PMC
The Interaction of Apelin and FGFR1 Ameliorated the Kidney Fibrosis through Suppression of TGFβ-Induced Endothelial-to-Mesenchymal Transition - PMC
Journal
Oxidative medicine and cellular longevity
Design, synthesis and evaluation of novel UDCA-aminopyrimidine hybrids as ATX inhibitors for the treatment of hepatic and pulmonary fibrosis
Journal
European journal of medicinal chemistry
Alpha-2 Heremans Schmid Glycoprotein (AHSG) promotes the proliferation of bladder cancer cells by regulating the TGF-β signalling pathway - PMC
The Ameliorative Role of Lico A on Aflatoxin B1-Triggered Hepatotoxicity Partially by Activating Nrf2 Signal Pathway
Journal
Journal of agricultural and food chemistry
Neuroepithelial cell-transforming 1 promotes cardiac fibrosis via the Wnt/-catenin signaling pathway - PMC
FK506 Induces the TGF-β1/Smad 3 Pathway Independently of Calcineurin Inhibition to Prevent Intervertebral Disk Degeneration
Journal
Front Cell Dev Biol
Deletion of GPR81 activates CREB/Smad7 pathway and alleviates liver fibrosis in mice - PMC
Journal
Molecular medicine (Cambridge, Mass.)
USF1 transcriptionally activates USP14 to drive atherosclerosis by promoting EndMT through NLRC5/Smad2/3 axis - PMC
Journal
Molecular medicine (Cambridge, Mass.)
Species
Homo sapiens,Mus musculus
Respiratory exposure to graphene quantum dots causes fibrotic effects on lung, liver and kidney of mice
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
GDF11 prevents the formation of thoracic aortic dissection in mice: Promotion of contractile transition of aortic SMCs
NRBE3 promotes metastasis of breast cancer by down-regulating E-cadherin expression
Journal
Biochimica et biophysica acta. Molecular cell research
NRBE3 promotes metastasis of breast cancer by down-regulating E-cadherin expression
Journal
Biochimica et biophysica acta. Molecular cell research
PNO1 promotes the progression of osteosarcoma via TGF- and YAP/TAZ pathway - PMC
Journal
Scientific reports
Inhibitory effects of Schisandrin C on collagen behavior in pulmonary fibrosis - PMC
Journal
Scientific reports
The silencing of NREP aggravates OA cartilage damage through the TGF-1/Smad2/3 pathway in chondrocytes - PMC
Journal
Journal of orthopaedic translation
Species
Homo sapiens, Mus musculus
IRAK-M Regulates Proliferative and Invasive Phenotypes of Lung Fibroblasts
Mir-454-3p induced WTX deficiency promotes hepatocellular carcinoma progressions through regulating TGF-β signaling pathway
Kinetin inhibits hepatic stellate cell activation and induces apoptosis via interactions with the TGF-1/Smad signaling pathway
Journal
Toxicology and applied pharmacology
PM2. 5 and water-soluble components induce airway fibrosis through TGF-β1/Smad3 signaling pathway in asthmatic rats
Journal
Molecular immunology
Network pharmacology and experimental verification to decode the action of Qing Fei Hua Xian Decotion against pulmonary fibrosis - PMC
Panax notoginseng saponins alleviate damage to the intestinal barrier and regulate levels of intestinal microbes in a rat model of chronic kidney disease - PMC
Rivaroxaban, a direct inhibitor of coagulation factor Xa, attenuates adverse cardiac remodeling in rats by regulating the PAR-2 and TGF-1 signaling pathways - PMC
Chlorogenic acid alleviates renal fibrosis by reducing lipid accumulation in diabetic kidney disease through suppressing the Notch1 and Stat3 signaling pathway - PMC
Species
Homo sapiens,Mus musculus
ITGBL1 transcriptionally inhibited by JDP2 promotes the development of pancreatic cancer through the TGF-beta/Smad pathway
Journal
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
ITGBL1 transcriptionally inhibited by JDP2 promotes the development of pancreatic cancer through the TGF-beta/Smad pathway
Journal
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
The involvement of leucine-rich α-2 glycoprotein in the progression of skin and lung fibrosis in bleomycin-induced systemic sclerosis model
Journal
Modern rheumatology
Hesperetin mitigates bile duct ligation-induced liver fibrosis by inhibiting extracellular matrix and cell apoptosis via the TGF-β1/Smad pathway
Journal
Current molecular medicine
Sirt1 Inhibits Atrial Fibrosis by Downregulating the Expression of the Transforming Growth Factor-1/Smad Pathway
Journal
Acta Cardiologica Sinica
Suppression of ADAM8 attenuates angiotensin II-induced cardiac fibrosis and endothelial-mesenchymal transition via inhibiting TGF-β1/Smad2/Smad3 pathways
Journal
Experimental animals
Sp1-Like Protein KLF13 Acts as a Negative Feedback Regulator of TGF-β Signaling and Fibrosis