Rabbit anti-Human Soluble Endothelial Protein C Receptor (sEPCR) mAb(DET) (RM98009)

说明书联系我们收藏

This standard curve is only for demonstration purposes. A standard curve should be generated for eachassay.

All(1)|

货号: RM98009

详细信息

产品名称

Rabbit anti-Human Soluble Endothelial Protein C Receptor (sEPCR) mAb(DET)

货号

RM98009

免疫原

Recombinant Human Soluble Endothelial Protein C Receptor (sEPCR)

纯化方式

Affinity purification

同种型

Rabbit IgG

存储溶液

Supplied as a 0.2um filtered solution in PBS with 0.1%Braveds MB-1,PH 7.6.

CrossReactivity

存储条件

This antibody can be stored at 2℃-8℃ for one monthwithout detectable loss of activity. Antibody products are stable for twelve months fromdate of receipt when stored at -20℃ to -82℃. Preservative-Free.Avoid repeated freeze-thaw cycles.

* This package insert must be read in its entirety before using this product.

应用

Human Soluble Endothelial Protein C Receptor (sEPCR) Sanwich ELISA Immunoassay

	Recommended Concentration	Sample
ELISA Capture	0.25-1ug/mL	Rabbit anti-Human Soluble Endothelial Protein C Receptor (sEPCR) mAb(CAP)(Cat. No.RM98008)
ELISA Detection	0.005-0.02ug/mL	Rabbit anti-Human Soluble Endothelial Protein C Receptor (sEPCR) mAb(DET)(Cat. No.RM98009)
Standard	0.31-20ng/mL	Recombinant Human Soluble Endothelial Protein C Receptor (sEPCR) Protein

背景信息

EPCR (the Endothelial Protein C Receptor), also known as CD201, is a transmembrane glyoprotein expressed on vascular endothelial cells. EPCR inhibits thrombosis through its interactions with Protein C, activated Protein C (APC), and Coagulation Factors VII, and VIIa. It enhances the activation of Protein C in response to complexes of Thrombin-Thrombomodulin. A soluble form of EPCR inhibits the anti-coagulant activity of APC. EPCR binds to CD11b/CD18 (Mac-1) on monocytes and mediates monocyte adhesion to the vascular endothelium. In addition, it binds to the antigen receptor on gamma/delta T cells, promotes hematopoietic stem cell retention in the bone marrow, and contributes to malaria pathogenicity through binding surface proteins on Plasmodium.