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Human FAP Sandwich ELISA Immunoassay
| Recommended Concentration | Sample | |
|---|---|---|
| ELISA Capture | 1-4ug/mL | Rabbit anti-Human FAP (CAP)(Cat. No.RMK0178） |
| ELISA Detection | 25-100ng/mL | Rabbit anti-Human FAP (DET) (Cat. No.RMK0179） |
| Standard | 0.156-10U/mL | Recombinant Human FAP Protein(Cat. No.RP01348LQ) |
FAP (also known as seprase) is a Type II transmembrane serine protease that is structurally related to dipeptidyl peptidase IV . FAP has substrate specificity similar to dipeptidyl peptidase IV, which is specific for N-terminal Xaa-Pro sequences, but FAP is also an endopeptidase able to degrade gelatin and Type I collagen. The enzymatically active form of FAP is a dimer . FAP has a restricted tissue distribution. It is not detectable in normal tissues or resting fibroblasts, but is highly expressed on reactive stromal fibroblasts in epithelial cancers , in granulation tissue during wound healing, and in bone and soft tissue sarcomas . Because of its expression patterns and enzymatic activities, FAP is believed to play roles in tumor invasion, tissue remodeling, and wound repair.
