Human HGF R on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Immobilized Human HGF R, hFc Tag at 5 μg/mL (100 μL/Well) on the plate. Dose response curve for Biotinylated Anti-HGF R Antibody, hFc Tag with the EC50 of 26.7ng/mL determined by ELISA.
Immobilized Human HGF, His Tag at 2 μg/mL (100 μL/Well) on the plate. Dose response curve for Human HGF R, hFc Tag with the EC50 of 23.7ng/mL determined by ELISA (QC Test).
c-Met, also called tyrosine-protein kinase Met or hepatocyte growth factor receptor (HGF R), is a protein that in humans is encoded by the MET gene.The protein possesses tyrosine kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling.
