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Recombinant Human PDGF-AA Protein (RP01772)

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Recombinant Human PDGF-AA Protein was determined by SDS-PAGE under reducing (R) and non-reducing (NR) conditions.

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货号: RP01772
价 格：  780.00
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详细信息

靶点
PDGFA
细胞系
14.31 kDa
突变描述
Lyophilized from a 0.22 μm filtered solution of 20 mM NaAc，pH 4.5

Mammalian cells such as human, rat and mouse cells are normally diploid with two alleles.
Homozygote: both alleles were knocked out, mRNA has no signal, no expression of proteins.
Heterozygote: only one allele was knocked out, the mRNA transcript levels was decreased compared to wild type, and the protein expression levels was also lower than that of the wild type.
敲除验证
20 kDa kDa
产品组成
Ser87-Thr211
物种
Pichia
保存条件
Store at -20℃
运输条件
Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.

背景信息

Platelet-derived growth factor alpha (PDGFA) is frequently upregulated in various cancers and thought to function as a key player in the development and progression of tumor growth by regulating aspects of cell proliferation, angiogenesis and metastasis. The human platelet-derived growth factor A chain gene (PDGFA) on chromosome 7p22 encodes an important mitogen. Within PDGFA lies a complex minisatellite structure that results in partial duplications of exon 4 and the IVS4 splice donor site.

基因ID
5154
Swiss Prot
P04085
别名
PDGF1; PDGF-A

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