Heat Shock Protein Inspired Nanochaperones Restore Amyloid-β Homeostasis for Preventative Therapy of Alzheimer's Disease.
Species
Mus musculus,Rattus norvegicus
Lighting up metastasis process before formation of secondary tumor by phosphorescence imaging - PMC
Oral delivery of anti-TNF antibody shielded by natural polyphenol-mediated supramolecular assembly for inflammatory bowel disease therapy
Sulforaphane attenuates microglia-mediated neuronal necroptosis through down-regulation of MAPK/NF-B signaling pathways in LPS-activated BV-2 microglia
Journal
Pharmacological Research
RhANP attenuates endotoxin-derived cognitive dysfunction through subdiaphragmatic vagus nerve-mediated gut microbiota–brain axis
Journal
J Neuroinflammation
Cell-specific NFIA upregulation promotes epileptogenesis by TRPV4-mediated astrocyte reactivity - PMC
Journal
Journal of neuroinflammation
Exploring the translational potential of PLGA nanoparticles for intra-articular rapamycin delivery in osteoarthritis therapy - PMC
Journal
Journal of nanobiotechnology
Cerium oxide nanoparticles-carrying human umbilical cord mesenchymal stem cells counteract oxidative damage and facilitate tendon regeneration - PMC
Journal
Journal of nanobiotechnology
Thermal stress involved in TRPV2 promotes tumorigenesis through the pathways of HSP70/27 and PI3K/Akt/mTOR in esophageal squamous cell carcinoma
Journal
British journal of cancer
Mir-331-3p Inhibits PRRSV-2 Replication and Lung Injury by Targeting PRRSV-2 ORF1b and Porcine TNF- α
Inhibition of CREB-mediated ZO-1 and Activation of NF-B-induced IL-6 by Colonic Epithelial MCT4 Destroys Intestinal Barrier Function.
Journal
Cell Proliferation
Species
Homo sapiens, Mus musculus
Bone marrow‐derived mesenchymal stem cells attenuate complete Freund's a djuvant‐induced inflammatory pain by inhibiting the expression of P2X3
Journal
Cell proliferation
Astrocyte senescence-like response related to peripheral nerve injury-induced neuropathic pain - PMC
Journal
Cellular & molecular biology letters
Vitamin K2 (Menaquinone-7) Reverses Age-Related Structural and Cognitive Deterioration in Naturally Aging Rats
Journal
Antioxidants (Basel, Switzerland)
Jiangzhi Granule attenuates non-alcoholic steatohepatitis by suppressing TNF/NFκB signaling pathway-a study based on network pharmacology
Journal
Biomed Pharmacother
DHA attenuates Aβ-induced necroptosis through the RIPK1/RIPK3 signaling pathway in THP-1 monocytes
Journal
Biomedicine & Pharmacotherapy
6-Methyl flavone inhibits Nogo-B expression and improves high fructose diet-induced liver injury in mice
Journal
Acta pharmacologica Sinica
A novel approach to repositioning memantine for metabolic syndrome-induced steatohepatitis: Modulation of hepatic autophagy, inflammation, and fibrosis
Carotid baroreceptor stimulation improves cardiac performance and reverses ventricular remodelling in canines with pacing-induced heart failure.
Species
Canis lupus familiaris
Biodegradation of HA and -TCP Ceramics Regulated by T-Cells - PMC
Esaxerenone Inhibits Renal Angiogenesis and Endothelial-Mesenchymal Transition via the VEGFA and TGF-1 Pathways in Aldosterone-Infused Mice - PMC
Journal
International journal of molecular sciences
Changes in the Expression and Functional Activities of C-X-C Motif Chemokine Ligand 13 (CXCL13) in Hyperplastic Prostate - PMC
Journal
International journal of molecular sciences
Species
Homo sapiens,Rattus norvegicus
Moderate Intensity Exercise May Protect Cardiac Function by Influencing Spleen Microbiome Composition
Exploring the potential molecular mechanism of trastuzumab-induced cardiotoxicity based on RNA sequencing and bioinformatics analysis
Journal
Biochemical pharmacology
Protective Effects of Ginsenosides on 17-Ethynyelstradiol-Induced Intrahepatic Cholestasis via Anti-Oxidative and Anti-Inflammatory Mechanisms in Rats
Journal
The American journal of Chinese medicine
Cattle Bile Arisaema Aqueous Extracts Protect Against Febrile Seizures in Rats Through Regulating Neurotransmitters and Suppressing Neuroinflammation - PMC
Journal
Frontiers in pharmacology
Protective effects of autophagy and NFE2L2 on reactive oxygen species-induced pyroptosis of human nucleus pulposus cells
Intranasal administration of β‐1, 3‐galactosyltransferase 2 confers neuroprotection against ischemic stroke by likely inhibiting oxidative stress and NLRP3 …
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Perillaldehyde: A promising antibacterial agent for the treatment of pneumonia caused by Acinetobacter baumannii infection
Journal
International immunopharmacology
Nogo-B inhibition restricts ulcerative colitis via inhibiting p68/miR-155 signaling pathway
Journal
International immunopharmacology
Species
Homo sapiens, Mus musculus
Sodium tanshinone IIA sulfonate attenuates sepsis-associated brain injury via inhibiting NOD-like receptor 3/caspase-1/gasdermin D-mediated pyroptosis
Journal
International immunopharmacology
Prevention of Hippocampal Neuronal Damage and Cognitive Function Deficits in Vascular Dementia by Dextromethorphan
Journal
Molecular Neurobiology
PTP1B Inhibitor Claramine Rescues Diabetes-Induced Spatial Learning and Memory Impairment in Mice
Journal
Molecular neurobiology
Inhibition of PKM2 suppresses osteoclastogenesis and alleviates bone loss in mouse periodontitis
Journal
International immunopharmacology
Biphasic photobiomodulation of inflammation in mouse models of common wounds, infected wounds, and diabetic wounds
Journal
Journal of photochemistry and photobiology. B, Biology
Synergetic and antagonistic molecular effects mediated by the feedback loop of p53 and JNK between Saikosaponin D and SP600125 on lung cancer A549 cells
Journal
Molecular Pharmaceutics
Immuno-PET Imaging of TNF-α in Colitis Using 89Zr-DFO-infliximab
Journal
Molecular pharmaceutics
Fabrication of Celecoxib PVP Microparticles Stabilized by Gelucire 48/16 via Electrospraying for Enhanced Anti-Inflammatory Action - PMC
Journal
Pharmaceuticals (Basel, Switzerland)
Novel anti-arthritic mechanisms of trans-cinnamaldehyde against complete Freund's adjuvant-induced arthritis in mice: involvement of NF-кB/TNF-α and IL-6/IL-23/ IL-17 pathways in the immuno-inflammatory responses
Journal
Inflammopharmacology
The emerging coloprotective effect of sildenafil against ulcerative colitis in rats via exerting counterbalance between NF-κB signaling and Nrf-2/HO-1 pathway - PMC
Journal
Inflammopharmacology
Lambda-cyhalothrin-induced pancreatic toxicity in adult albino rats - PMC
Journal
Scientific reports
Mutant and curli-producing E. coli enhance the disease phenotype in a hSOD1-G93A mouse model of ALS - PMC
Journal
Scientific reports
Taurine inhibits KDM3a production and microglia activation in lipopolysaccharide-treated mice and BV-2 cells
Journal
Molecular and cellular neurosciences
PK2/PKRs pathway is involved in the protective effect of artemisinin against trimethyltin chloride-induced hippocampal injury
Quercetin inhibits caspase-1-dependent macrophage pyroptosis in experimental folic acid nephropathy - PMC
Urban Particulate Matter Triggers Meibomian Gland Dysfunction - PMC
Journal
Investigative ophthalmology & visual science
Puerarin decreases bone loss and collagen destruction in rats with ligature-induced periodontitis
Journal
Journal Of Periodontal Research
DNA damage‐inducible transcript 3 deficiency promotes bone resorption in murine periodontitis models
Journal
Journal of periodontal research
Downregulation of IL-1/p38 mitogen activated protein kinase pathway by diacerein protects against kidney ischemia/reperfusion injury in rats
Treadmill exercise mitigates neuroinflammation and increases BDNF via activation of SIRT1 signaling in a mouse model of T2DM
D-beta-hydroxybutyrate protects against microglial activation in lipopolysaccharide-treated mice and BV-2 cells
Journal
Metabolic brain disease
Resveratrol suppresses bone cancer pain in rats by attenuating inflammatory responses through the AMPK/Drp1 signaling
Journal
Acta Biochimica et Biophysica Sinica
Effects of combined treatment with PD‑L1 Ig and CD40L mAb on immune tolerance in the CBA/J x DBA/2 mouse model
Journal
Molecular Medicine Reports
MCPIP1 alleviates depressive-like behaviors in mice by inhibiting the TLR4/TRAF6/NF-B pathway to suppress neuroinflammation - PMC
Journal
Molecular medicine reports
Alleviation effect of conjugated linoleic acid on estradiol benzoate induced fatty liver hemorrhage syndrome in Hy-line male chickens
Journal
Journal of animal science
Electroacupuncture Alleviates Neuroinflammation by Inhibiting the HMGB1 Signaling Pathway in Rats with Sepsis-Associated Encephalopathy - PMC
Micro124-mediated AHR expression regulates the inflammatory response of chronic rhinosinusitis (CRS) with nasal polyps
Journal
biochemical and biophysical research communications
Microglial integrin, chemokine receptors, and inflammatory response vary with development
Journal
Biochemical and biophysical research communications
Resveratrol ameliorates oxaliplatin-induced neuropathic pain via anti-inflammatory effects in rats - PMC
Journal
Experimental and therapeutic medicine
Eplerenone ameliorates lung fibrosis in unilateral ureteral obstruction rats by inhibiting lymphangiogenesis - PMC
Journal
Experimental and therapeutic medicine
The Mitigatory Effect of Shen-Qi Compound on the Diabetic Thoracic Aortic Complications through Inhibiting the Inflammatory Microenvironment by miR-223-3p/RBP-J/IRF8 Axis - PMC
Journal
Evidence-based complementary and alternative medicine : eCAM