凋亡经典信号通路-程序性细胞死亡专题- ABclonal

凋亡经典信号通路

凋亡是最早被发现的程序性细胞死亡的首要形式，是在生理或病理条件下，由特定的死亡信号通路激活并最终导致不需要的或异常细胞从组织中清除[1]。从形态学特征来看，凋亡细胞表现出胞质皱缩，质膜出芽，磷脂酰丝氨酸（PS）外翻，染色质浓缩和DNA断裂[2,3]。整个凋亡过程中细胞膜保持完整，没有内含物释放，不会引起机体炎症反应 [4]。
凋亡是一个精细复杂的级联调控过程，有两个主要的凋亡途径：外源性途径（死亡受体途径）和内源性途径（线粒体途径）。两种途径相互联系、共同参与凋亡调节[5,6]。外源性途径由细胞表面的死亡受体（如Fas和肿瘤坏死因子受体家族成员）及相关配体引发[7]，参与的配体和相应的死亡受体包括FasL / Fas，TNF-α/ TNFR1，Apo3L / DR3，Apo2L / DR4和Apo2L / DR5 [8-11]。接头蛋白（FADD / TRADD）招募 caspase-8和/或caspase-10，从而导致死亡诱导信号复合物（DISC）的形成，caspase-8 寡聚化并通过自催化被激活，激活的caspase-8 进而诱导下游级联[12]。活化的caspase-8/10将其他caspases（caspase-3/6/7）前体切割成活化形式的caspases。这些活化的执行阶段的caspase，会导致各种细胞结构（如细胞骨架和细胞核）成分的降解。当caspase-8被抑制或阻断时，RIPK1和RIPK3相互作用导致自磷酸化、转磷酸化和“坏死复合体”（由RIPK1、RIPK3和MLKL组成）的组装，从而进一步启动一种替代形式的程序性细胞死亡，即程序性坏死[13-15]。
内源性凋亡途径由细胞内应激或损伤信号（如内质网应激、氧化应激、DNA损伤）触发，在线粒体水平汇聚并启动下游信号级联传递[16, 17]。随后激活的Bcl-2家族促凋亡成员（如Bax，Bak等）中和抗凋亡蛋白Bcl-2、Bcl-xL和Mcl-1，使得线粒体外膜通透性（MOMP）的破坏，导致细胞色素c释放[18]。细胞色素c结合并激活Apaf-1和pro-caspase-9，形成“凋亡小体” [19]，然后激活执行阶段的caspase（caspase-3/6/7），导致多种细胞底物降解和细胞凋亡[20, 21]。

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ABclonal提供凋亡信号研究特色产品

Caspase-9 Rabbit mAb

Western blot analysis of lysates from Mouse brain, using Caspase-9 Rabbit mAb (A11910) at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25μg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 10s.

Immunohistochemistry analysis of Caspase-9 in paraffin-embedded human liver cancer tissue using Caspase-9 Rabbit mAb (A11910) at a dilution of 1:800 (40x lens).High pressure antigen retrieval was performed with 0.01 M citrate buffer (pH 6.0) prior to IHC staining.

Immunohistochemistry analysis of Caspase-9 in paraffin-embedded human liver tissue using Caspase-9 Rabbit mAb (A11910) at a dilution of 1:800 (40x lens).High pressure antigen retrieval was performed with 0.01 M citrate buffer (pH 6.0) prior to IHC staining.

Immunohistochemistry analysis of Caspase-9 in paraffin-embedded mouse spleen tissue using Caspase-9 Rabbit mAb (A11910) at a dilution of 1:800 (40x lens).High pressure antigen retrieval was performed with 0.01 M citrate buffer (pH 6.0) prior to IHC staining.

Immunohistochemistry analysis of Caspase-9 in paraffin-embedded rat spleen tissue using Caspase-9 Rabbit mAb (A11910) at a dilution of 1:800 (40x lens).High pressure antigen retrieval was performed with 0.01 M citrate buffer (pH 6.0) prior to IHC staining.

Confocal imaging of PC-12 cells using Caspase-9 Rabbit mAb (A11910,dilution 1:100) followed by a further incubation with Cy3 Goat Anti-Rabbit IgG (H+L) (AS007,dilution 1:500)(Red).The cells were counterstained with α-Tubulin Mouse mAb (AC012, dilution 1:400) followed by incubation with ABflo® 488-conjugated Goat Anti-Mouse IgG (H+L) Ab (AS076, dilution 1:500) (Green).DAPI was used for nuclear staining (Blue). Objective: 100x.

Confocal imaging of NIH/3T3 cells using Caspase-9 Rabbit mAb (A11910,dilution 1:100) followed by a further incubation with Cy3 Goat Anti-Rabbit IgG (H+L) (AS007,dilution 1:500)(Red).The cells were counterstained with α-Tubulin Mouse mAb (AC012, dilution 1:400) followed by incubation with ABflo® 488-conjugated Goat Anti-Mouse IgG (H+L) Ab (AS076, dilution 1:500) (Green).DAPI was used for nuclear staining (Blue). Objective: 100x.

Confocal imaging of HeLa cells using Caspase-9 Rabbit mAb (A11910,dilution 1:100) followed by a further incubation with Cy3 Goat Anti-Rabbit IgG (H+L) (AS007,dilution 1:500)(Red).The cells were counterstained with α-Tubulin Mouse mAb (AC012, dilution 1:400) followed by incubation with ABflo® 488-conjugated Goat Anti-Mouse IgG (H+L) Ab (AS076, dilution 1:500) (Green).DAPI was used for nuclear staining (Blue). Objective: 100x.

AIF Rabbit mAb

Western blot analysis of various lysates using AIF Rabbit mAb (A19536) at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25μg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 30s.

Immunohistochemistry analysis of paraffin-embedded human oophoroma using AIF Rabbit mAb (A19536) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.

PARP1 Rabbit mAb

Western blot analysis of lysates from Jurkat cells, using PARP1 Rabbit mAb (A19596) at 1:1000 dilution.Jurkat cells were treated by Staurosporine(1uM) at room temperature for 3 hours .
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25μg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 1s.

Western blot analysis of various lysates using PARP1 Rabbit mAb (A19596) at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25μg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 1s.

Immunohistochemistry analysis of paraffin-embedded Human colon using PARP1 Rabbit mAb (A19596) at dilution of 1:200 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate Bufferr (pH 6.0) prior to IHC staining.

Immunohistochemistry analysis of paraffin-embedded Human liver cancer using PARP1 Rabbit mAb (A19596) at dilution of 1:200 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate Bufferr (pH 6.0) prior to IHC staining.

Immunohistochemistry analysis of paraffin-embedded Human placenta using PARP1 Rabbit mAb (A19596) at dilution of 1:200 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate Bufferr (pH 6.0) prior to IHC staining.

Immunohistochemistry analysis of paraffin-embedded Human spleen using PARP1 Rabbit mAb (A19596) at dilution of 1:200 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate Bufferr (pH 6.0) prior to IHC staining.

Immunohistochemistry analysis of paraffin-embedded Human tonsil using PARP1 Rabbit mAb (A19596) at dilution of 1:200 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate Bufferr (pH 6.0) prior to IHC staining.

Immunohistochemistry analysis of paraffin-embedded Mouse brain using PARP1 Rabbit mAb (A19596) at dilution of 1:200 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate Bufferr (pH 6.0) prior to IHC staining.

Immunohistochemistry analysis of paraffin-embedded Mouse colon using PARP1 Rabbit mAb (A19596) at dilution of 1:200 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate Bufferr (pH 6.0) prior to IHC staining.

Immunohistochemistry analysis of paraffin-embedded Mouse kidney using PARP1 Rabbit mAb (A19596) at dilution of 1:200 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate Bufferr (pH 6.0) prior to IHC staining.

Immunohistochemistry analysis of paraffin-embedded Mouse testis using PARP1 Rabbit mAb (A19596) at dilution of 1:200 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate Bufferr (pH 6.0) prior to IHC staining.

Immunohistochemistry analysis of paraffin-embedded Rat brain using PARP1 Rabbit mAb (A19596) at dilution of 1:200 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate Bufferr (pH 6.0) prior to IHC staining.

Immunohistochemistry analysis of paraffin-embedded Rat heart using PARP1 Rabbit mAb (A19596) at dilution of 1:200 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate Bufferr (pH 6.0) prior to IHC staining.

Immunohistochemistry analysis of paraffin-embedded Rat liver using PARP1 Rabbit mAb (A19596) at dilution of 1:200 (40x lens). High pressure antigen retrieval performed with 0.01M Citrate Bufferr (pH 6.0) prior to IHC staining.

Immunofluorescence analysis of HeLa cells using PARP1 Rabbit mAb (A19596) at dilution of 1:50 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) (AS007) at 1:500 dilution. Blue: DAPI for nuclear staining.

Immunofluorescence analysis of paraffin-embedded human lung using PARP1 Rabbit mAb (A19596) at dilution of 1:50 (40x lens). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) (AS007) at 1:500 dilution. Blue: DAPI for nuclear staining.

Caspase-3 Rabbit mAb

Western blot analysis of various lysates, using [KO Validated] active + pro Caspase-3 Rabbit mAb (A19654) at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25μg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 3min.

Western blot analysis of lysates from Jurkat cells, using [KO Validated] active + pro Caspase-3 Rabbit mAb (A19654) at 1:1000 dilution.Jurkat cells were treated by Etoposide (25 uM) at 37℃ for 5 hours.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25μg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 90s.

Western blot analysis of lysates from L929 cells, using [KO Validated] active + pro Caspase-3 Rabbit mAb (A19654) at 1:1000 dilution.L929 cells were treated by staurosporine(1 uM) for 3 hour.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25μg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 180s.

Bax Rabbit mAb

Western blot analysis of various lysates using Bax Rabbit mAb (A19684) at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25μg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 90s.

Western blot analysis of various lysates using Bax Rabbit mAb (A19684) at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates / proteins: 25 μg per lane.
Blocking buffer: 3 % nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 30s.

Western blot analysis of lysates from wild type (WT) and Bax knockout (KO) 293T cells using Bax Rabbit mAb (A19684) at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25 μg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 30s.

Immunohistochemistry analysis of paraffin-embedded rat spleen using Bax Rabbit mAb (A19684) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma using Bax Rabbit mAb (A19684) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.

Bcl-2 Rabbit mAb

Western blot analysis of various lysates using Bcl-2 Rabbit mAb (A19693) at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25μg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 3min.

Immunohistochemistry analysis of paraffin-embedded human tonsil using Bcl-2 Rabbit mAb (A19693) at dilution of 1:100 (40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.

Immunohistochemistry analysis of paraffin-embedded human follicular lymphoma using Bcl-2 Rabbit mAb (A19693) at dilution of 1:100 (40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.

Immunohistochemistry analysis of paraffin-embedded human appendix using Bcl-2 Rabbit mAb (A19693) at dilution of 1:100 (40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.

Immunoprecipitation analysis of 200 μg extracts of Mouse lung using 3 μg Bcl-2 antibody (A19693). Western blot was performed from the immunoprecipitate using Bcl-2 antibody (A19693) at a dilution of 1:1000.

VDAC1 Rabbit mAb

Western blot analysis of various lysates using VDAC1 Rabbit mAb (A19707) at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25μg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit (RM00020).
Exposure time: 1s.

Immunohistochemistry analysis of paraffin-embedded Human colon carcinoma tissue using VDAC1 Rabbit mAb (A19707) at a dilution of 1:200 (40x lens). High pressure antigen retrieval was performed with 0.01 M citrate buffer (pH 6.0) prior to IHC staining.

Immunohistochemistry analysis of paraffin-embedded Human liver tissue using VDAC1 Rabbit mAb (A19707) at a dilution of 1:200 (40x lens). High pressure antigen retrieval was performed with 0.01 M citrate buffer (pH 6.0) prior to IHC staining.

Immunohistochemistry analysis of paraffin-embedded Human thyroid cancer tissue using VDAC1 Rabbit mAb (A19707) at a dilution of 1:200 (40x lens). High pressure antigen retrieval was performed with 0.01 M citrate buffer (pH 6.0) prior to IHC staining.

Immunohistochemistry analysis of paraffin-embedded Mouse kidney tissue using VDAC1 Rabbit mAb (A19707) at a dilution of 1:200 (40x lens). High pressure antigen retrieval was performed with 0.01 M citrate buffer (pH 6.0) prior to IHC staining.

Immunohistochemistry analysis of paraffin-embedded Rat kidney tissue using VDAC1 Rabbit mAb (A19707) at a dilution of 1:200 (40x lens). High pressure antigen retrieval was performed with 0.01 M citrate buffer (pH 6.0) prior to IHC staining.

Confocal imaging of HeLa cells using VDAC1 Rabbit mAb (A19707,dilution 1:100)(Red). The cells were counterstained with α-Tubulin Mouse mAb (AC012,dilution 1:400) (Green). DAPI was used for nuclear staining (blue). Objective: 100x.

Confocal imaging of C6 cells using VDAC1 Rabbit mAb (A19707, dilution 1:200) followed by a further incubation with Cy3 Goat Anti-Rabbit IgG (H+L) (AS007, dilution 1:500) (Red). The cells were counterstained with α-tubulin Mouse mAb (AC012, dilution 1:400) followed by incubation with ABflo® 488-conjugated Goat Anti-Mouse IgG (H+L) Ab (AS076, dilution 1:500) (Green). DAPI was used for nuclear staining (Blue). Objective: 100x.

Confocal imaging of HeLa cells using VDAC1 Rabbit mAb (A19707, dilution 1:200) followed by a further incubation with Cy3 Goat Anti-Rabbit IgG (H+L) (AS007, dilution 1:500) (Red). The cells were counterstained with α-tubulin Mouse mAb (AC012, dilution 1:400) followed by incubation with ABflo® 488-conjugated Goat Anti-Mouse IgG (H+L) Ab (AS076, dilution 1:500) (Green). DAPI was used for nuclear staining (Blue). Objective: 100x.

Confocal imaging of L-929 cells using VDAC1 Rabbit mAb (A19707, dilution 1:200) followed by a further incubation with Cy3 Goat Anti-Rabbit IgG (H+L) (AS007, dilution 1:500) (Red). The cells were counterstained with α-tubulin Mouse mAb (AC012, dilution 1:400) followed by incubation with ABflo® 488-conjugated Goat Anti-Mouse IgG (H+L) Ab (AS076, dilution 1:500) (Green). DAPI was used for nuclear staining (Blue). Objective: 100x.

Confocal imaging of NIH/3T3 cells using VDAC1 Rabbit mAb (A19707, dilution 1:200) followed by a further incubation with Cy3 Goat Anti-Rabbit IgG (H+L) (AS007, dilution 1:500) (Red). The cells were counterstained with α-tubulin Mouse mAb (AC012, dilution 1:400) followed by incubation with ABflo® 488-conjugated Goat Anti-Mouse IgG (H+L) Ab (AS076, dilution 1:500) (Green). DAPI was used for nuclear staining (Blue). Objective: 100x.

Caspase-12 Rabbit mAb

Western blot analysis of various lysates, using Caspase-12 Rabbit mAb (A22864) at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (AS014) at 1:10000 dilution.
Lysates/proteins: 25μg per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Enhanced Kit (RM00021).
Exposure time: 60s.

Immunohistochemistry analysis of Caspase-12 in paraffin-embedded Human lung adenocarcinoma tissue using Caspase-12 Rabbit mAb (A22864) at a dilution of 1:800 (40x lens). High pressure antigen retrieval was performed with 0.01 M citrate buffer (pH 6.0) prior to IHC staining.

Immunohistochemistry analysis of Caspase-12 in paraffin-embedded human thyroid cancer tissue using Caspase-12 Rabbit mAb (A22864) at a dilution of 1:800 (40x lens). High pressure antigen retrieval was performed with 0.01 M citrate buffer (pH 6.0) prior to IHC staining.

Immunohistochemistry analysis of Caspase-12 in paraffin-embedded rat colon tissue using Caspase-12 Rabbit mAb (A22864) at a dilution of 1:800 (40x lens). High pressure antigen retrieval was performed with 0.01 M citrate buffer (pH 6.0) prior to IHC staining.

Confocal imaging of paraffin-embedded Mouse brain tissue using Caspase-12 Rabbit mAb (A22864, dilution 1:200) followed by a further incubation with Cy3 Goat Anti-Rabbit IgG (H+L) (AS007, dilution 1:500) (Red). DAPI was used for nuclear staining (Blue). Microwave antigen retrieval performed with 0.01M Citrate Buffer(pH 6.0) prior to IF staining. Objective: 40x.

Confocal imaging of paraffin-embedded Rat brain tissue using Caspase-12 Rabbit mAb (A22864, dilution 1:200) followed by a further incubation with Cy3 Goat Anti-Rabbit IgG (H+L) (AS007, dilution 1:500) (Red). DAPI was used for nuclear staining (Blue). Microwave antigen retrieval performed with 0.01M Citrate Buffer(pH 6.0) prior to IF staining. Objective: 40x.

凋亡信号通路精选研究产品

分类

研究靶点	产品货号	产品名称	应用	物种

Bcl2家族(促生存)

BCL2	A19693	Bcl-2 Rabbit mAb	ELISA,WB,IHC-P,IP	Human, Mouse, Rat
BCL2	A20777	Bcl-2 Mouse mAb	ELISA,WB,IHC-P,IF/ICC	Human, Mouse, Rat
MCL1	A0434	MCL1 Rabbit pAb	ELISA,WB,IF/ICC	Mouse, Rat
BCL2L2	A1158	Bcl-W Rabbit pAb	ELISA,WB	Mouse, Rat
BCL2L1	A23766	Bcl-XL Rabbit mAb	ELISA,WB,IHC-P	Human, Mouse, Rat
BCL2L1	A0209	Bcl-XL Rabbit pAb	ELISA,WB,IHC-P,IF/ICC	Human, Rat

Bcl2家族(促凋亡)

BAX	A19684	Bax Rabbit mAb	ELISA,WB,IHC-P	Human, Mouse, Rat
BAX	A20227	[KO Validated] Bax Rabbit mAb	ELISA,WB,IF/ICC,IP	Human, Mouse, Rat
BAK1	A23523	[KD Validated] Bak Rabbit mAb	ELISA,WB,IHC-P	Human, Mouse
BAD	A19595	Bad Rabbit mAb	ELISA,WB,IHC-P	Human, Mouse, Rat
BAD	AP1010	Phospho-Bad-S112 Rabbit mAb	ELISA,WB	Human, Mouse
BID	A0210	Bid Rabbit pAb	ELISA,WB,IF/ICC	Human, Mouse, Rat
BID	A23234	[KD Validated] Bid Rabbit mAb	ELISA,WB	Human
BCL2L11	A19702	Bim Rabbit mAb	ELISA,WB	Human, Mouse, Rat
BBC3	A3752	PUMA Rabbit mAb	ELISA,WB,IHC-P,IF/ICC	Human, Mouse, Rat

Caspase家族

CASP2	A4888	Caspase-2 Rabbit mAb	ELISA,WB	Human
CASP2	A5724	Caspase-2 Rabbit pAb	ELISA,WB	Human, Mouse, Rat
CASP3	A17900	Caspase-3 Mouse mAb	ELISA,WB	Human, Mouse
CASP3	A19654	Caspase-3 Rabbit mAb	ELISA,WB	Human, Mouse, Rat
CASP3	A2156	[KO Validated] Caspase-3 Rabbit pAb	ELISA,WB,IHC-P,IF/ICC	Human, Mouse, Rat
CASP3	A11021	Active Caspase-3 Rabbit mAb	ELISA,WB	Human
CASP3	A19664	Caspase-3 p12 Rabbit mAb	ELISA,WB,IHC-P,IF/ICC	Human, Mouse, Rat
CASP6	A19559	Caspase-6 Rabbit mAb	ELISA,WB,IF/ICC	Human, Mouse
CASP6	A19552	Caspase-6 Rabbit mAb	ELISA,WB, IF/ICC	Human, Rat
CASP7	A1524	Caspase-7 Rabbit pAb	ELISA,WB,IHC-P,IF/ICC	Human, Mouse, Rat
CASP8	A19549	[KO Validated] Caspase-8 Rabbit mAb	ELISA,WB	Human
CASP8	A0215	Caspase-8 Rabbit pAb	ELISA,WB,IHC-P,IF/ICC	Human, Mouse, Rat
CASP9	A11910	Caspase-9 Rabbit mAb	ELISA,WB,IHC-P,IF/ICC	Human, Mouse, Rat
CASP9	A18676	Caspase-9 Rabbit mAb	ELISA,WB,IF/ICC	Human, Mouse, Rat
CASP10	A0216	Caspase-10 Rabbit pAb	ELISA,WB	Human
CASP12	A0217	Caspase-12 Rabbit pAb	ELISA,WB,IHC-P	Human, Mouse, Rat
CASP12	A22864	Caspase-12 Rabbit mAb	ELISA,WB,IHC-P,IF/ICC	Human, Mouse, Rat

死亡受体及相关蛋白

TNFRSF10A	A12540	TNFRSF10A Rabbit pAb	ELISA,WB,IF/ICC	Human, Mouse, Rat
TNFRSF10A	A24703	DR4 Rabbit mAb	ELISA,FC	Human
TNFRSF10B	A19043	DR5/TRAILR2/TNFRSF10B Rabbit mAb	ELISA,WB,IHC-P,IF/ICC	Human, Mouse, Rat
FAS	A19582	Fas Rabbit mAb	ELISA,WB,IHC-P	Human, Rat
FAS	A21903	Fas Rabbit mAb	ELISA,WB	Human, Mouse
TNFRSF1A	A1540	TNFR1/TNFRSF1A Rabbit pAb	ELISA,WB,IHC-P,IF/ICC	Human, Mouse, Rat
TNFRSF1B	A19127	TNFR2/TNFRSF1B Rabbit mAb	ELISA,WB	Human, Mouse, Rat
Tradd	A1145	TRADD Rabbit pAb	ELISA,WB	Human, Mouse
Fadd	A19838	FADD Rabbit mAb	ELISA,WB,IHC-P	Human, Mouse, Rat
TRAF2	A19129	[KD Validated] TRAF2 Rabbit mAb	ELISA,WB,IP	Human, Mouse, Rat
RIPK1	A19580	RIPK1/RIP Rabbit mAb	ELISA,WB,IP	Human
RIPK1	AP1448	Phospho-RIPK1-S166 Rabbit mAb	ELISA,WB	Human

凋亡调节分子

BIRC2	A19688	[KO Validated] cIAP1 Rabbit mAb	ELISA,WB,IHC-P	Human, Rat
BIRC3	A0833	cIAP2 Rabbit pAb	ELISA,WB,IHC-P,IF/ICC	Human, Mouse, Rat
XIAP	A20846	[KO Validated] XIAP Rabbit mAb	ELISA,WB	Human, Mouse, Rat
CFLAR	A2555	cFLIP Rabbit pAb	ELISA,WB	Human, Mouse, Rat

线粒体凋亡途径相关蛋白

CYCS	A4912	Cytochrome C Rabbit mAb	ELISA,WB,IHC-P	Human, Mouse, Rat
CYCS	A13430	Cytochrome C Rabbit pAb	ELISA,WB,IHC-P,IF/ICC	Human, Mouse, Rat
APAF1	A0751	APAF1 Rabbit pAb	ELISA,WB,IF/ICC	Human, Mouse, Rat
VDAC1	A19707	VDAC1 Rabbit mAb	ELISA,WB,IHC-P,IF/ICC	Human, Mouse, Rat
AIFM1	A19536	AIF Rabbit mAb	ELISA,WB,IHC-P	Human, Mouse, Rat
AIFM1	A2568	[KO Validated] AIF Rabbit pAb	ELISA,WB,IHC-P,IF/ICC	Human, Mouse, Rat
ENDOG	A8801	Endo G Rabbit mAb	ELISA,WB	Human, Mouse, Rat
HTRA2	A3904	HTRA2 Rabbit mAb	ELISA,WB	Human, Mouse, Rat
SEPTIN4	A10238	Septin 4 Rabbit pAb	ELISA,WB,IHC-P,IF/ICC	Human, Mouse, Rat
DIABLO	A8889	Smac/Diablo Rabbit mAb	ELISA,WB,IHC-P,IF/ICC	Human, Mouse, Rat

DNA片段化相关

PARP1	A18303	PARP1 Mouse mAb	ELISA,WB	Human, Mouse
PARP1	A19596	PARP1 Rabbit mAb	ELISA,WB,IHC-P,IF/ICC	Human, Mouse, Rat
PARP1	A19612	Cleaved PARP1 p25 Rabbit mAb	ELISA,WB,IP	Human, Mouse
PARP1	A0942	PARP1 Rabbit pAb	ELISA,WB,IF/ICC	Human, Mouse, Rat
DFFB	A10110	DFFB Rabbit pAb	ELISA,WB,IHC-P	Human, Mouse

缩略语注释:
PS, phosphatidylserine
TNFR, tumor necrosis factor receptor
FasL, Fas Ligand
Apo2L, also called TRAIL, TNF superfamily, member 10
Apo3L, also called TWEAK, TNF superfamily, member 12
DR, Death Receptor
FADD, Fas-associated protein with death domain
TRADD, TNFRSF1A associated protein with death domain
Bax, BCL2 associated X, apoptosis regulator
Bak, BCL2 antagonist/killer 1
Bcl-2, B cell leukemia/lymphoma 2
Bcl-xL, also called Bcl2l1, BCL2-like 1
Mcl-1, myeloid cell leukemia sequence 1, apoptosis regulator, BCL2 family member
MOMP, membrane outer membrane permeability
Apaf-1, apoptotic peptidase activating factor 1

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