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* This package insert must be read in its entirety before using this product.
Human TNF RII Sandwich ELISA Immunoassay
| Recommended Concentration | Sample | |
|---|---|---|
| ELISA Capture | 1-4ug/mL | Rabbit anti-Human TNF RII mAb(CAP)(Cat. No.RMK0085 ) |
| ELISA Detection | 0.17-0.67ug/mL | Rabbit anti-Human TNF RII mAb(DET)(Cat. No.RMK0086 ) |
| Standard | 15.63-1000pg/mL | Recombinant Human TNF RII Protein(Cat. No.RP00252) |
Tumor necrosis factors (TNFs) are pleiotropic cytokines that are considered primary modifiers of the inflammatory and immune reactions of animals produced in response to injury or infection. Two forms of TNF, designated TNF-α (or cachectin) and TNF-β (or lymphotoxin), have been described that share 30% sequence similarity and compete for binding to the same receptors. TNFs play a necessary and beneficial role as mediators of host resistance to infections and tumor formation, however, over-production or inappropriate expression of these factors can lead to a variety of pathological conditions, including wasting, systemic toxicity, and septic shock.
