CircHAS2 activates CCNE2 to promote cell proliferation and sensitizes the response of colorectal cancer to anlotinib
PR-SET7 epigenetically restrains uterine interferon response and cell death governing proper postnatal stromal development - PMC
Journal
Nature communications
Species
Oryctolagus cuniculus
PR-SET7 epigenetically restrains uterine interferon response and cell death governing proper postnatal stromal development - PMC
Journal
Nature communications
Species
Oryctolagus cuniculus
Diphthamide deficiency promotes association of eEF2 with p53 to induce p21 expression and neural crest defects - PMC
Journal
Nature communications
The mitochondria‒paraspeckle axis regulates the survival of transplanted stem cells under oxidative stress conditions - PMC
Genetically Modified Hepatocytes Targeting Bilirubin and Ammonia Metabolism for the Construction of Bioartificial Liver System - PMC
Journal
Biomaterials research
The involvement of krüppel-like transcription factor 2 in megakaryocytic differentiation induction by phorbol 12-myrestrat 13-acetate - PMC
Journal
Biomarker research
Long noncoding RNA MAGI2-AS3 regulates the H2O2 level and cell senescence via HSPA8 - PMC
Oroxylin A regulates cGAS DNA hypermethylation induced by methionine metabolism to promote HSC senescence
Journal
Pharmacological research
Sirtuin 4 (Sirt4) downregulation contributes to chondrocyte senescence and osteoarthritis via mediating mitochondrial dysfunction - PMC
Journal
International journal of biological sciences
P21 facilitates macrophage chemotaxis by promoting CCL7 in the lung epithelial cell lines treated with radiation and bleomycin - PMC
Journal
Journal of translational medicine
Species
Homo sapiens, Mus musculus
Barasertib impedes chondrocyte senescence and alleviates osteoarthritis by mitigating the destabilization of heterochromatin induced by AURKB
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Oroxylin A activates ferritinophagy to induce hepatic stellate cell senescence against hepatic fibrosis by regulating cGAS-STING pathway
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
20-Deoxyingenol alleviates intervertebral disc degeneration by activating TFEB in nucleus pulposus cells
Journal
Biochemical pharmacology
Bepotastine sensitizes ovarian cancer to PARP inhibitors through suppressing NF-B-triggered SASP in cancer-associated fibroblasts
Journal
Molecular cancer therapeutics
Investigating the effects and mechanisms of Erchen Decoction in the treatment of colorectal cancer by network pharmacology and experimental validation - PMC
Journal
Frontiers in pharmacology
Liproxstatin‑1 induces cell cycle arrest, apoptosis, and caspase‑3/GSDME‑dependent secondary pyroptosis in K562 cells
Journal
International journal of oncology
MORC4 plays a tumor-promoting role in colorectal cancer via regulating PCGF1/CDKN1A axis in vitro and in vivo
Journal
Cancer gene therapy
Nobiletin restores HFD-induced enteric nerve injury by regulating enteric glial activation and the GDNF/AKT/FOXO3a/P21 pathway - PMC
Journal
Molecular medicine (Cambridge, Mass.)
WNT16 elevation induced cell senescence of osteoblasts in ankylosing spondylitis
Journal
Arthritis Res Ther
Genkwanin alleviates intervertebral disc degeneration via regulating ITGA2/PI3K/AKT pathway and inhibiting apoptosis and senescence
Journal
International immunopharmacology
Renal lipid accumulation and aging linked to tubular cells injury via ANGPTL4
Journal
Mechanisms of ageing and development
Design and synthesis of N-(1-(6-(substituted phenyl)-pyridazin-3-yl)-piperidine-3-yl)-amine derivatives as JMJD6 inhibitors
Journal
Bioorganic chemistry
LukS-PV inhibits the proliferation of hepatocellular carcinoma cells by maintaining FOXO3 stability via the PI3K/AKT signaling pathway
Journal
Cellular signalling
Deubiquitinating enzyme PSMD7 promotes bladder cancer development: Involvement of RAB1A stabilization
Journal
Cellular signalling
Natural compound library screening identifies Sanguinarine chloride for the treatment of SCLC by upregulating CDKN1A
Journal
Translational oncology
MUC3A promotes the progression of colorectal cancer through the PI3K/Akt/mTOR pathway
Mogrol suppresses lung cancer cell growth by activating AMPK-dependent autophagic death and inducing p53-dependent cell cycle arrest and apoptosis
Journal
Toxicology and applied pharmacology
Iron overload causes macrophages to produce a proinflammatory phenotype in the synovium of hemophiliac arthritis via the acetylp53 pathway
Journal
Haemophilia : the official journal of the World Federation of Hemophilia
Activation of α7nAChR by PNU282987 improves cognitive impairment through inhibiting oxidative stress and neuroinflammation in D-galactose induced …
Journal
Experimental gerontology
Activation of α7nAChR by PNU282987 improves cognitive impairment through inhibiting oxidative stress and neuroinflammation in D-galactose induced …
Journal
Experimental gerontology
Andrographolide induced ferroptosis in multiple myeloma cells by regulating the P38/Nrf2/HO-1 pathway
Journal
Archives of biochemistry and biophysics
Mitochondrial citrate accumulation triggers senescence of alveolar epithelial cells contributing to pulmonary fibrosis in mice - PMC
EZH2 inhibitor Tazemetostat synergizes with JQ-1 in esophageal cancer by inhibiting c-Myc signaling pathway
Journal
Medical oncology (Northwood, London, England)
Species
Homo sapiens, Mus musculus
Rad54L promotes bladder cancer progression by regulating cell cycle and cell senescence
Journal
Medical oncology (Northwood, London, England)
E2F1 inhibits cellular senescence and promotes oxaliplatin resistance in colorectal cancer - PMC
Journal
Annals of translational medicine
Homocysteinepotentiated Kelchlike ECHassociated protein 1 promotes senescence of neuroblastoma 2a cells via inhibiting ubiquitination of catenin
Journal
The European journal of neuroscience
SHCBP1 contributes to the proliferation and self-renewal of cervical cancer cells and activation of the NF-B signaling pathway through EIF5A - PMC
CMTR1 promotes colorectal cancer cell growth and immune evasion by transcriptionally regulating STAT3 - PMC
Journal
Cell death & disease
The Hyperproliferation Mechanism of Cholesteatoma Based on Proteomics: SNCA Promotes Autophagy-Mediated Cell Proliferation through the PI3K/AKT
Journal
Molecular & cellular proteomics : MCP