神经炎症关键研究靶点

在神经炎症的发生和发展过程中，多个信号通路和关键靶点发挥了重要作用，包括NF-κB信号通路，NLRP3 炎性体通路，MAPK 信号通路等

AIF1 ALOX5 ASC/TMS1 CARS Caspase-1 CD11b CD163 IL1 beta IL10 LRRK2 NLRP3 NOX2/gp91phox p38 MAPK TREM2

ASC/TMS1

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ASC/TMS1 是一种接头蛋白，它会在有组织损伤或感染性威胁的情况下介导炎性体的形成。炎性体活性异常会导致阿尔茨海默病、多发性硬化和帕金森病的进展。

Confocal imaging of paraffin-embedded Mouse spleen using ASC/TMS1 Rabbit mAb (A24165,dilution 1:200) followed by a further incubation with Cy3 Goat Anti-Rabbit IgG (H+L) (AS007, dilution 1:500)(Red). DAPI was used for nuclear staining (Blue). Objective: 40x. Perform high pressure antigen retrieval with 0.01 M citrate buffer (pH 6.0) prior to IF staining.

NLRP3

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NLRP3是NOD样受体（NLRs）家族中的一员，参与炎症反应和细胞死亡过程，尤其是通过形成NLRP3炎症小体来发挥作用，主要通过激活 IL-1β 和 IL-18 成为神经炎症的一个关键病因

Confocal imaging of RAW 264.7 cells (treated with LPS) and RAW 264.7 cells (untreated) using NLRP3 Rabbit mAb (A24294, dilution 1:200) followed by a further incubation with Cy3 Goat Anti-Rabbit IgG (H+L) (AS007, dilution 1:500) (Red). DAPI was used for nuclear staining (Blue). Objective: 100x.