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Human CTLA4 Sandwich ELISA Immunoassay
Recommended Concentration | Sample | |
---|---|---|
ELISA Capture | 1-4ug/mL | Rabbit anti-Human CTLA4 mAb(CAP)(Cat. No.RM17921) |
ELISA Detection | 0.016-0.6ug/mL | Rabbit anti-Human CTLA4 mAb(DET)(Cat. No.RM17922) |
Standard | 15.6-1000pg/mL | Recombinant Human CTLA4 Protein(Cat. No.RP01044) |
This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.