Macrophage Inactivation
by Small Molecule Wedelolactone
via Targeting sEH for the Treatment of LPS-Induced Acute Lung Injury - PMC
Journal
ACS central science
Direct targeting of sEH with alisol B alleviated the apoptosis, inflammation, and oxidative stress in cisplatin-induced acute kidney injury - PMC
Journal
International journal of biological sciences
Targeting miR-31 represses tumourigenesis and dedifferentiation of BRAFV600E-associated thyroid carcinoma - PMC
Journal
Clinical and translational medicine
Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway
Journal
Pharmacological research
Oxidative stress-induced mitophagy is suppressed by the miR-106b-93-25 cluster in a protective manner
Artificial intelligence framework identifies candidate targets for drug repurposing in Alzheimer’s disease
Journal
Alzheimer's research & therapy
ANKRD1 activates the Wnt signaling pathway by modulating CAV3 expression and thus promotes BMSC osteogenic differentiation and bone formation in …
Journal
Biochimica et biophysica acta. Molecular basis of disease
Acteoside ameliorates learning and memory impairment in APP/PS1 transgenic mice by increasing A degradation and inhibiting tau hyperphosphorylation
Journal
Phytotherapy research : PTR
Novel Peptide Derived from Gadus morhua Stimulates Osteoblastic Differentiation and Mineralization through Wnt/-Catenin and BMP Signaling Pathways
Journal
Journal of agricultural and food chemistry
Tirzepatide ameliorates spatial learning and memory impairment through modulation of aberrant insulin resistance and inflammation response in diabetic rats - PMC
Journal
Frontiers in pharmacology
Toosendanin suppresses oncogenic phenotypes of human gastric carcinoma SGC?7901 cells partly via miR?200a?mediated downregulation of β-catenin pathway
Journal
International Journal of Oncology
Protective efficacy of Schizandrin B on ameliorating nephrolithiasis via regulating GSK3/Nrf2 signaling-mediated ferroptosis in vivo and in vitro
Journal
International immunopharmacology
Species
Homo sapiens,Rattus norvegicus
Phosphorylation of MITF by AKT affects its downstream targets and causes TP53-dependent cell senescence
Journal
The international journal of biochemistry & cell biology
Dcf1 deficiency induces hypomyelination by activating Wnt signaling
Journal
Experimental neurology
Establishment of a prognostic risk model for osteosarcoma and mechanistic investigation - PMC
Journal
Frontiers in pharmacology
Learning and memory impairment and transcriptomic profile in hippocampus of offspring after maternal fructose exposure during gestation and lactation
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Apigenin inhibits proliferation and differentiation of cardiac fibroblasts through AKT/GSK3 signaling pathway
Journal
Journal of ethnopharmacology
HTRA3 transcriptionally inhibited by FOXP1 suppresses tumorigenesis of osteosarcoma via the PTEN/PI3K/AKT pathway
Journal
Biochimica et biophysica acta. Molecular cell research
Ethanol Extract of Rosa laevigata Michx. Fruit Inhibits Inflammatory Responses through NF-B/MAPK Signaling Pathways via AMPK Activation in RAW 264.7 Macrophages - PMC
Journal
Molecules (Basel, Switzerland)
Selenium supplementation protects against oxidative stress-induced cardiomyocyte cell cycle arrest through activation of PI3K/AKT
Journal
Metallomics : integrated biometal science
Koumine induces apoptosis in Cyprinus carpio liver cells by regulating JAK-STAT and p53 signaling pathways
Journal
Fish & shellfish immunology
Synergistic Effect of Flavonoids and Metformin on Protection of the Methylglyoxal-Induced Damage in PC-12 Neuroblastoma Cells: Structure-Activity Relationship and Potential Target - PMC
Journal
Molecules (Basel, Switzerland)
Periostin activates pathways involved in epithelial-mesenchymal transition in adamantinomatous craniopharyngioma
Journal
Journal Of The Neurological Sciences
Oridonin Inhibits Mycobacterium marinum Infection-Induced Oxidative Stress In Vitro and In Vivo - PMC
Journal
Pathogens (Basel, Switzerland)
Oridonin Inhibits Mycobacterium marinum Infection-Induced Oxidative Stress In Vitro and In Vivo - PMC
Journal
Pathogens (Basel, Switzerland)
Anwulignan Ameliorates the Intestinal Ischemia/Reperfusion
Journal
The Journal of pharmacology and experimental therapeutics
The Effect of Selenium on Endometrial Repair in Goats with Endometritis at High Cortisol Levels
Journal
Biological trace element research
Dietary supplementation of salidroside alleviates liver lipid metabolism disorder and inflammatory response to promote hepatocyte regeneration via PI3K/AKT/Gsk3- pathway - PMC
TSPAN31 suppresses cell proliferation in human cervical cancer through down‐regulation of its antisense pairing with CDK4
Journal
Cell biochemistry and function
The effect of lithium chloride on the attenuation of cognitive impairment in experimental hypoglycemic rats.
Journal
Brain research bulletin
Schisandra chinensis acidic polysaccharide partialy reverses acetaminophen-induced liver injury in mice
Journal
Journal of pharmacological sciences
Depsidone and xanthones from Garcinia xanthochymus with hypoglycemic activity and the mechanism of promoting glucose uptake in L6 myotubes
Journal
Bioorganic & Medicinal Chemistry
ZnSO4 Protects against premature ovarian failure through PI3K/AKT/GSK3β signaling pathway
Endophenotype-based in silico network medicine discovery combined with insurance record data mining identifies sildenafil as a candidate drug for Alzheimer's disease
Species
Homo sapiens, Mus musculus