Discovery of a potent allosteric activator of DGKQ that ameliorates obesity-induced insulin resistance via the sn-1, 2-DAG-PKCε signaling axis
Imipramine activates FAM3A-FOXA2-CPT2 pathway to ameliorate hepatic steatosis
Journal
Metabolism: clinical and experimental
Depletion of ApoA5 aggravates spontaneous and diet-induced nonalcoholic fatty liver disease by reducing hepatic NR1D1 in hamsters
SOX4 promotes beige adipocyte-mediated adaptive thermogenesis by facilitating PRDM16-PPARγ complex - PMC
SIRT5 Regulates Brown Adipocyte Differentiation and Browning of Subcutaneous White Adipose Tissue.
Rab18 maintains homeostasis of subcutaneous adipose tissue to prevent obesity-induced metabolic disorders
Journal
Science China. Life sciences
CRISPRa-based activation of Fgf21 and Fndc5 ameliorates obesity by promoting adipocytes browning - PMC
Journal
Clinical and translational medicine
Species
Homo sapiens, Mus musculus
Dehydroabietic Acid Alleviates High Fat Diet-Induced Insulin Resistance and Hepatic Steatosis Through Dual Activation of PPAR- and PPAR-
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Species
Homo sapiens, Mus musculus
Pyrazolone derivative C29 protects against HFD-induced obesity in mice via activation of AMPK in adipose tissue
Journal
Acta Pharmacol Sin
L-Arabinose Elicits Gut-Derived Hydrogen Production and Ameliorates Metabolic Syndrome in C57BL/6J Mice on High-Fat-Diet
Zeaxanthin Ameliorates Obesity by Activating 3-adrenergic Receptor to Stimulate Inguinal Fat Thermogenesis and Modulating Gut Microbiota
Physical Activity Attenuates the Obesity-Induced Dysregulated Expression of Brown Adipokines in Murine Interscapular Brown Adipose Tissue
Transplantation of Adipose-Tissue-Engineered Constructs with CRISPR-Mediated UCP1 Activation - PMC
Journal
International journal of molecular sciences
SAMM50 Regulates Thermogenesis of Beige Adipocytes Differentiated from Human Adipose-Derived Stem Cells by Balancing Mitochondrial Dynamics - PMC
Journal
International journal of molecular sciences
SAMM50 Regulates Thermogenesis of Beige Adipocytes Differentiated from Human Adipose-Derived Stem Cells by Balancing Mitochondrial Dynamics - PMC
Journal
International journal of molecular sciences
Sesamol promotes browning of white adipocytes through liver-adipose crosstalk signal of hepatic fibroblast growth factor 21
Journal
The Journal of nutritional biochemistry
Species
Homo sapiens, Mus musculus
Genetic ablation of diabetes-associated gene Ccdc92 reduces obesity and insulin resistance in mice - PMC
Diphyllin Improves High-Fat Diet-Induced Obesity in Mice Through Brown and Beige Adipocytes
Journal
Front Endocrinol (Lausanne)
Hepatocyte TGF‐β Signaling Inhibiting WAT Browning to Promote NAFLD and Obesity Is Associated With Let‐7b‐5p
Journal
Hepatology communications
Extract of Ephedra sinica Stapf Induces Browning of Mouse and Human White Adipocytes
Journal
Foods (Basel, Switzerland)
Species
Homo sapiens, Mus musculus
Rutaecarpine Promotes Adipose Thermogenesis and Protects against HFD-Induced Obesity via AMPK/PGC-1 Pathway
Journal
Pharmaceuticals (Basel, Switzerland)
Semaglutide 6-months therapy of type 2 diabetes mellitus restores adipose progenitors potential to develop metabolically active adipocytes
Journal
European journal of pharmacology
Gut microbiota induces hepatic steatosis by modulating the T cells balance in high fructose diet mice - PMC
Journal
Scientific reports
Creatine ameliorates high-fat diet-induced obesity by regulation of lipolysis and lipophagy in brown adipose tissue and liver
Exosomal IL-8 derived from Lung Cancer and Colon Cancer cells induced adipocyte atrophy via NF-B signaling pathway - PMC
Journal
Lipids in health and disease
Egg white hydrolysate protects white adipose tissue against metabolic insult in deoxycorticosterone acetate-salt rats
Journal
The British journal of nutrition
18: 0 Lyso PC, a natural product with potential PPAR-γ agonistic activity, plays hypoglycemic effect with lower liver toxicity and cardiotoxicity in db/db mice
Journal
Biochem Biophys Res Commun
Effects of exercise and dietary intervention on muscle, adipose tissue, and blood IRISIN levels in obese male mice and their relationship with the beigeization of white adipose tissue
Journal
Endocrine connections
Rutin promotes white adipose tissue browning and brown adipose tissue activation partially through the calmodulin-dependent protein kinase kinase /AMP
Glucagon-like Peptide-1 Improves Fatty Liver and Enhances Thermogenesis in Brown Adipose Tissue via Inhibiting BMP4-Related Signaling Pathway in High-Fat-Diet-Induced Obese Mice
Dapagliflozin promotes browning of white adipose tissue through the FGFR1-LKB1-AMPK signaling pathway - PMC
Journal
Molecular biology reports