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This standard curve is only for demonstration purposes. A standard curve should be generated for eachassay.
Fromthe comparison of the standard curve, it is found that ABclonal has highsensitivity.
* This package insert must be read in its entirety before using this product.
Sheep IL-6 Sanwich ELISA Immunoassay
| Recommended Concentration | Sample | |
|---|---|---|
| ELISA Capture | 0.25-1ug/mL | Rabbit anti-Sheep IL-6 (CAP)(Cat. No.RM17804) |
| ELISA Detection | 0.08-0.02ug/mL | Rabbit anti-Sheep IL-6 (DET)(Cat. No.RM17805) |
| Standard | 15.6-1000pg/mL | Recombinant Sheep IL-6 Protein |
Cytokine with a wide variety of biological functions in immunity, tissue regeneration, and metabolism. Binds to IL6R, then the complex associates to the signaling subunit IL6ST/gp130 to trigger the intracellular IL6-signaling pathway. The interaction with the membrane-bound IL6R and IL6ST stimulates 'classic signaling', whereas the binding of IL6 and soluble IL6R to IL6ST stimulates 'trans-signaling'. Alternatively, 'cluster signaling' occurs when membrane-bound IL6:IL6R complexes on transmitter cells activate IL6ST receptors on neighboring receiver cells.By Similarity IL6 is a potent inducer of the acute phase response. Rapid production of IL6 contributes to host defense during infection and tissue injury, but excessive IL6 synthesis is involved in disease pathology.
