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Mouse IL-10 Multiplex
Recommended Concentration | Sample | ||
---|---|---|---|
Multiplex | Capture | 0.1-5ug/mL | Rabbit anti-Mouse IL-10 mAb(Cat. No. RM17935) |
Detection | 0.5-2ug/mL | Rabbit anti-Mouse IL-10 mAb (Cat. No.RMK0423) | |
Standard | 6.86-5000pg/mL | Recombinant Mouse IL-10 Protein (Cat. No.RP01465) |
Interleukin-10 (IL-10), also known as cytokine synthesis inhibitory factor (CSIF), is the charter member of the IL-10 alpha -helical cytokine family that also includes IL-19, IL-20, IL-22, IL-24, and IL-26/AK155 (1-3). IL-10 is secreted by many activated hematopoietic cell types as well as hepatic stellate cells, keratinocytes, and placental cytotrophoblasts. Whereas human IL-10 is active on mouse cells, mouse IL-10 does not act on human cells (4, 5). Mature mouse IL-10 shares 85% amino acid sequence identity with rat IL-10 and 70-77% with bovine, canine, equine, feline, human, ovine, and porcine IL-10. It contains two intrachain disulfide bridges and is expressed as a 36 kDa noncovalently-associated homodimer