Recombinant Human HGK2/DDR1/CD167a Protein was resolved with SDS-PAGE under reducing (Lane 1) and non-reducing (Lane 2) conditions.
The activity of DDR1 is based on the MSA technology, and the content and ratio of the substrate and the product are directly separated and detected in real time and dynamically by the different migration rates of the substrate and the product after the enzymatic reaction.
DDR1 also known as discoidin domain receptor family member 1 or CD167a belongs to a subfamily of receptor tyrosine kinases (RTKs) with a homology region to the Dictyostelium discoideum protein discoidin I in their extracellular domain. And it is widely expressed in normal and transformed epithelial cells and is activated by various types of collagen. In situ studies and Northern-blot analysis showed that expression of DDR1 is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, this protein is significantly overexpressed in several human tumors from breast, ovarian, esophageal, and pediatric brain.
