Recombinant Human Sortilin/SORT1 Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 85-95 KDa.
Immobilized Recombinant Human Sortilin/SORT1 Protein at 2 μg/mL (100 μL/well) can bind biotinylated Recombinant Human Progranulin Protein, the EC50 is 500-1500 ng/mL.
The Sortilin is a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex. The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer.
