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Recombinant Human SHP-2/PTPN11 Protein (RP03279LQ)

Recombinant Human PTPN11/SHP-2 Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 95-100 kDa.

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货号: RP03279LQ
促销价:   ¥3200
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详细信息

种属
Human
表达宿主
Baculovirus-Insect Cells
Calculated MW
98 kDa
Observed MW
98 kDa
标签
N-GST
纯度
> 90% by SDS-PAGE.
内毒素
Please contact us for more information.
制剂
Supplied as a 0.22 μm filtered solution of 20 mM MOPS, 300 mM NaCl, 10 mM glutathione, 0.25-1 mM DTT, 0-0.1 mM PMSF, 10-25% glycerol, pH 7.5. Contact us for customized product form or formulation.
描述
Recombinant Human SHP-2/PTPN11 Protein is produced by Baculovirus-Insect Cells expression system. The target protein is expressed with sequence (Met1-Arg593) of human SHP-2/PTPN11 (Accession #NM_002834) fused with a GST tag at the N-terminus.
储存
Store at -70℃. This product is stable at ≤ -70℃ for up to 1 year from the date of receipt. For optimal storage, aliquot into smaller quantities after centrifugation and store at recommended temperature. Avoid repeated freeze-thaw cycles.未开盖的干粉蛋白在 -20°C至-80°C可保存12个月;
复溶之后,蛋白溶液在-20°C及以下可保存3个月,在2-8℃可保存1周。
生物活性
Please contact us for more information.

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背景信息

PTPN11/SHP-2 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.

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