Recombinant Human Transcription factor SOX-2/SOX2 Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 35 kDa.
The SOX (SRY homology box) family of proteins comprises 20 individual members in man and mouse, of which SOX2 is the most explored. SOX proteins are principally defined by a conserved DNA-binding element, the so-called high mobility group (HMG) that relates to a transcriptional master regulator of virility. The SOX family branches into eight sub-categories (SoxA-H), of which SoxB further divides into SoxB1 and SoxB2 groups reflecting more recent gene duplication events. While Sox proteins contribute to various cellular functionalities, reprogramming capacity is largely confined to members of the SoxB1 group (i.e., Sox1, Sox2, and Sox3). SOX2 imposes transcription modulatory significance often in conjunction with co-factors such as OCT3/4 in ES cells or PAX6 in the visual system primordia. And SOX2 enables the derivation of human or murine induced pluripotent stem cells (iPSCs) from terminally differentiated somatic cells.
