Magnetic responsive hydroxyapatite scaffold modulated macrophage polarization through PPAR/JAK-STAT signaling and enhanced fatty acid metabolism
Insights into the effects of difenoconazole on the livers in male mice at the biochemical and transcriptomic levels
Targeted knockdown of PGAM5 in synovial macrophages efficiently alleviates osteoarthritis - PMC
Simvastatin re-sensitizes hepatocellular carcinoma cells to sorafenib by inhibiting HIF-1/PPAR-/PKM2-mediated glycolysis
Journal
Journal of Experimental & Clinical Cancer Research : CR
Genipin-activating PPAR impedes CCR2-mediated macrophage infiltration into postoperative liver to suppress recurrence of hepatocellular carcinoma - PMC
Journal
International journal of biological sciences
Impaired PPAR activation by cadmium exacerbates infection-induced lung injury
Carbon dots derived from folic acid attenuates osteoarthritis by protecting chondrocytes through NF-κB/MAPK pathway and reprogramming macrophages - PMC
Journal
Journal of nanobiotechnology
Neuron derived fractalkine promotes microglia to absorb hematoma via CD163/HO-1 after intracerebral hemorrhage
Journal
Cellular and molecular life sciences : CMLS
Echinacea purpurea polysaccharide prepared by fractional precipitation prevents alcoholic liver injury in mice by protecting the intestinal barrier and regulating liver-related pathways
Journal
Int J Biol Macromol
Dendrobium officinale regulate lipid metabolism in diabetic mouse liver via PPAR-RXR signaling pathway: Evidence from an integrated multi-omics analysis
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
The new coumarin compound Bis 3 ameliorates cognitive disorder and suppresses brain-intestine-liver systematic oxidative stress in high-fat diet mice
Journal
Biomed Pharmacother
Huoluo Xiaoling Pellet promotes microglia M2 polarization through increasing MCPIP1 expression for ischemia stroke alleviation
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Attenuation by Time-Restricted Feeding of High-Fat and High-Fructose Diet-Induced NASH in Mice Is Related to Per2 and Ferroptosis - PMC
Journal
Oxidative medicine and cellular longevity
Exercise attenuates angiotensinⅡ-induced muscle atrophy by targeting PPARγ/miR-29b
Journal
J Sport Health Sci
Hypermethylation of PPARG-encoding gene promoter mediates fine particulate matter-induced pulmonary fibrosis by regulating the HMGB1/NLRP3 axis
Journal
Ecotoxicology and environmental safety
Chemical constituents and anti-inflammatory activity of the total alkaloid extract from Melodinus cochinchinensis (Lour.) Merr. and its inhibition of the NF-κB and MAPK signaling pathways
Species
Melodinus cochinchinensis
Salvianolactone acid A isolated from Salvia miltiorrhiza ameliorates lipopolysaccharide-induced acute lung injury in mice by regulating PPAR-
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Species
Homo sapiens,Mus musculus
Vildagliptin inhibits high fat and fetuin-A mediated DPP-4 expression, intracellular lipid accumulation and insulin secretory defects in pancreatic beta cells
Journal
Biochimica et biophysica acta. Molecular basis of disease
Inhibition of macrophage-derived foam cells by Adipsin attenuates progression of atherosclerosis
Journal
Biochimica et biophysica acta. Molecular basis of disease
Inhibition of macrophage-derived foam cells by Adipsin attenuates progression of atherosclerosis
Journal
Biochimica et biophysica acta. Molecular basis of disease
Consumption of Saturated Fatty AcidsRich Lard Benefits Recovery of Experimental Arthritis by Activating PPAR
Journal
Molecular nutrition & food research
PP2A in LepR+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through Runx2 dephosphorylation
Peiminine regulates bonefat balance by canonical Wnt/catenin pathway in an ovariectomized rat model
Journal
Phytotherapy research : PTR
Application
WB, IHC, IF, RT-qPCR
Camellia ( Camellia oleifera bel.) seed oil reprograms gut microbiota and alleviates lipid accumulation in high fat-fed mice through the mTOR pathway
Identification and experimental validation of immune-related gene PPARG is involved in ulcerative colitis
Journal
Biochimica et biophysica acta. Molecular basis of disease
Let-7a-5p Regulates Animal Lipid Accumulation by Targeting Srebf2 and Thbs1 Signaling - PMC
Journal
International journal of molecular sciences
Species
Oryctolagus cuniculus
Sesamol promotes browning of white adipocytes through liver-adipose crosstalk signal of hepatic fibroblast growth factor 21
Journal
The Journal of nutritional biochemistry
Species
Homo sapiens, Mus musculus
Walnut-Derived Peptides Ameliorate Scopolamine-Induced Memory Impairments in a Mouse Model via Activation of Peroxisome Proliferator-Activated Receptor
Journal
Journal of agricultural and food chemistry
The peroxisome proliferator-activated receptor γ agonist pioglitazone prevents NF-κB activation in cisplatin nephrotoxicity through the reduction of p65 acetylation via the AMPK-SIRT1/p300 pathway
Journal
Biochemical Pharmacology
Lycopene Prevents DEHP-Induced Liver Lipid Metabolism Disorder by Inhibiting the HIF-1α-Induced PPARα/PPARγ/FXR/LXR System
PPARγ Mediates the Cardioprotective Roles of Danlou Tablet After Acute Myocardial Ischemia-Reperfusion Injury
Journal
Frontiers in cardiovascular medicine
Maternal intermittent fasting deteriorates offspring metabolism via suppression of hepatic mTORC1 signaling
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
PPAR- with its anti-fibrotic action could serve as an effective therapeutic target in T-2 toxin-induced cardiac fibrosis of rats
Peroxisome proliferator-activated receptor gamma participates in the acquisition of brain ischemic tolerance induced by ischemic preconditioning via glial glutamate transporter 1 in vivo and in vitro
Journal
Journal of neurochemistry
Cadmium-mediated lung injury is exacerbated by the persistence of classically activated macrophages
Deciphering Risperidone-Induced Lipogenesis by Network Pharmacology and Molecular Validation
Journal
Frontiers in psychiatry
Species
Homo sapiens, Mus musculus
Competing endogenous RNA networks were associated with fat accumulation in skeletal muscle of aged male mice
Journal
Mechanisms of ageing and development
PPARγ/NF-κB and TGF-β1/Smad pathway are involved in the anti-fibrotic effects of levo-tetrahydropalmatine on liver fibrosis
Zeaxanthin prevents ferroptosis by promoting mitochondrial function and inhibiting the p53 pathway in free fatty acid-induced HepG2 cells
Journal
Biochimica et biophysica acta. Molecular and cell biology of lipids
Role of gut microbiota on regulation potential of Dendrobium officinale Kimura & Migo in metabolic syndrome: In-vitro fermentation screening and in-vivo verification in
Journal
Journal of ethnopharmacology
Forsythiae Fructuse extracts alleviates LPS-induced acute lung injury in mice by regulating PPAR-γ/RXR-α in lungs and colons
Journal
Journal of ethnopharmacology
Pyruvate Might Bridge Gut Microbiota and Muscle Health in Aging Mice After Chronic High Dose of Leucine Supplementation
Journal
Front Med (Lausanne)
Torularhodin Alleviates Hepatic Dyslipidemia and Inflammations in High-Fat Diet-Induced Obese Mice via PPARα Signaling Pathway - PMC
Journal
Molecules (Basel, Switzerland)
Resistant dextrin improves high-fat-high-fructose diet induced insulin resistance.
Journal
Nutrition & Metabolism
Securidaca inappendiculata-Derived Xanthones Protected Joints from Degradation in Male Rats with Collagen-Induced Arthritis by Regulating PPAR- Signaling
The long non-coding RNA lncMYOZ2 mediates an AHCY/MYOZ2 axis to promote adipogenic differentiation in porcine preadipocytes - PMC
miR-22-3p/PGC1 β Suppresses Breast Cancer Cell Tumorigenesis via PPAR γ
The protective effect of HOXA5 on carotid atherosclerosis occurs by modulating the vascular smooth muscle cell phenotype
Journal
Mol Cell Endocrinol
Transcriptome-Based Analysis Reveals Therapeutic Effects of Resveratrol on Endometriosis in aRat Model
Journal
Drug Des Devel Ther
Convallatoxin Promotes M2 Macrophage Polarization to Attenuate Atherosclerosis Through PPARγ-Integrin α v β 5 Signaling Pathway
Journal
Drug Des Devel Ther
The Lnc-HOTAIR/miR122/PPAR signaling mediated the occurrence and continuous development of alcohol-induced Osteonecrosis of the femoral head
Journal
Toxicology letters
Application
WB, IF, IHC, Co-IP
MALAT1 Up-Regulator Polydatin Protects Brain Microvascular Integrity and Ameliorates Stroke Through C/EBPβ/MALAT1/CREB/PGC-1α/PPARγ Pathway.
Journal
Cellular and molecular neurobiology
Analysis of the role of irisin receptor signaling in regulating osteogenic/adipogenic differentiation of bone marrow mesenchymal stem cells
Journal
Biotechnology & genetic engineering reviews
Fatty acid binding protein 3 deficiency limits atherosclerosis development via macrophage foam cell formation inhibition
miR-24-3p Dominates the Proliferation and Differentiation of Chicken Intramuscular Preadipocytes by Blocking ANXA6 Expression
HBx induced upregulation of FATP2 promotes the development of hepatic lipid accumulation
Journal
Experimental cell research
Phenotypic characterization of a novel type 2 diabetes animal model in a SHANXI MU colony of Chinese hamsters.
Species
Mesocricetus auratus
Overexpression of AKR1C3 significantly enhances human prostate cancer cells resistance to radiation.
Cr (VI)-induced overactive mitophagy contributes to mitochondrial loss and cytotoxicity in L02 hepatocytes
Journal
The Biochemical journal
The Regulation of Autophagy by p38 MAPK–PPARγ Signaling During the Brain Ischemic Tolerance Induced by Cerebral Ischemic Preconditioning
Journal
DNA and cell biology
Astragalus polysaccharide mitigates transport stress-induced hepatic metabolic stress via improving hepatic glucolipid metabolism in chicks
Journal
Journal of animal science
Effects of miR-29c on proliferation and adipogenic differentiation of porcine bone marrow mesenchymal stromal cells - PMC
Species
Oryctolagus cuniculus
miR-34a regulates adipogenesis in porcine intramuscular adipocytes by targeting ACSL4
Arisaema heterophyllum Blume Monomer Stigmasterol Targets PPARγ and Inhibits the Viability and Tumorigenicity of Lung Adenocarcinoma Cells NCI-H1975 - PMC
Journal
Evidence-based complementary and alternative medicine : eCAM
Arisaema heterophyllum Blume Monomer Stigmasterol Targets PPARγ and Inhibits the Viability and Tumorigenicity of Lung Adenocarcinoma Cells NCI-H1975 - PMC
Journal
Evidence-based complementary and alternative medicine : eCAM
Improving obesity and lipid metabolism using conjugated linoleic acid
Journal
Veterinary medicine and science
Cytoplasmic PPAR Significantly Correlates With P53 Immunohistochemical Expression and Tumor Size in Localized Tenosynovial Giant Cell Tumor - PMC
M2a macrophages facilitate resolution of chemically-induced colitis in TLR4-SNP mice
Comprehensive Analysis of Alteration Landscape and Its Clinical Significance of Mitochondrial Energy Metabolism Pathway-Related Genes in Lung Cancers
Journal
Oxid Med Cell Longev