miR-301a promotes lung tumorigenesis by suppressing Runx3.
Circular RNA circTADA2A promotes osteosarcoma progression and metastasis by sponging miR-203a-3p and regulating CREB3 expression.
Aspartoacylase suppresses prostate cancer progression by blocking LYN activation - PMC
Journal
Military Medical Research
Cellular MembraneEngineered Nanovesicles as ThreeStage Booster to Target Lesion Core
Journal
Advanced materials (Deerfield Beach, Fla.)
Porous microneedle patch with sustained delivery of extracellular vesicles mitigates severe spinal cord injury - PMC
Journal
Nature communications
Rosmarinic Acid‐Crosslinked Supramolecular Nanoassembly with Self‐Regulated Photodynamic and Anti‐Metastasis Properties for Synergistic Photoimmunotherapy
Journal
Small (Weinheim an der Bergstrasse, Germany)
Regulating Macrophage Polarization in High Glucose Microenvironment Using Lithium-Modified Bioglass-Hydrogel for Diabetic Bone Regeneration
Journal
Advanced healthcare materials
Oxidative stress mediated by the TLR4/NOX2 signalling axis is involved in polystyrene microplastic-induced uterine fibrosis in mice
Journal
The Science of the total environment
Oroxylin A suppresses ACTN1 expression to inactivate cancer-associated fibroblasts and restrain breast cancer metastasis
Nebulized milk exosomes loaded with siTGF-1 ameliorate pulmonary fibrosis by inhibiting EMT pathway and enhancing collagen permeability - PMC
Journal
Journal of nanobiotechnology
NIR light-responsive bacteria with live bio-glue coatings for precise colonization in the gut
Usp8 promotes tumor cell migration through activating the JNK pathway
Journal
Cell death & disease
SNRPB promotes the tumorigenic potential of NSCLC in part by regulating RAB26.
Journal
Cell death & disease
NOX4 blockade suppresses titanium nanoparticle-induced bone destruction via activation of the Nrf2 signaling pathway
Journal
Journal of nanobiotechnology
Two distinct males absent on the first (MOF)-containing histone acetyltransferases are involved in the epithelial-mesenchymal transition in different ways in human cells
Journal
Cellular and molecular life sciences : CMLS
Alpha-ketoglutarate ameliorates abdominal aortic aneurysm via inhibiting PXDN/HOCL/ERK signaling pathways - PMC
Journal
Journal of translational medicine
Protective role of hydrogen sulfide against diabetic cardiomyopathy by inhibiting pyroptosis and myocardial fibrosis
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Dual PI3K/mTOR inhibitor PF-04979064 regulates tumor growth in gastric cancer and enhances drug sensitivity of gastric cancer cells to 5-FU
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
CB2 regulates oxidative stress and osteoclastogenesis through NOX1-dependent signaling pathway in titanium particle-induced osteolysis - PMC
Journal
Cell death discovery
NREP, transcriptionally upregulated by HIF-1, aggravates breast cancer cell growth and metastasis by promoting glycolysis - PMC
Journal
Cell death discovery
Brusatol Suppresses the Tumor Growth and Metastasis of Colorectal Cancer via Upregulating ARRDC4 Expression through Modulating PI3K/YAP1/TAZ Pathway
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Oncopeptide MBOP Encoded by LINC01234 Promotes Colorectal Cancer through MAPK Signaling Pathway
MicroRNA-375-3p enhances chemosensitivity to 5-fluorouracil by targeting thymidylate synthase in colorectal cancer.
Injectable rhein-assisted crosslinked hydrogel for efficient local osteosarcoma chemotherapy
Journal
International journal of pharmaceutics
CD56 polysialylation promotes the tumorigenesis and progression via the Hedgehog and Wnt/-catenin signaling pathways in clear cell renal cell carcinoma - PMC
Journal
Cancer cell international
Combination of dihydroartemisinin and resveratrol effectively inhibit cancer cell migration via regulation of DLC1/TCTP/Cdc42 pathway
Molecular mechanisms of selenium-biofortified soybean protein and polyphenol conjugates in protecting mouse skin damaged by UV-B
Using circular RNA SMARCA5 as a potential novel biomarker for hepatocellular carcinoma
Journal
Clinica chimica acta; international journal of clinical chemistry
Galangin inhibits neointima formation induced by vascular injury via regulating the PI3K/AKT/mTOR pathway
Combination of ACY-241 and JQ1 Synergistically Suppresses Metastasis of HNSCC via Regulation of MMP-2 and MMP-9
Multiple-Purpose Connectivity Map Analysis Reveals the Benefits of Esculetin to Hyperuricemia and Renal Fibrosis
Xanthones from the Bark of Garcinia xanthochymus and the Mechanism of Induced Apoptosis in Human Hepatocellular Carcinoma HepG2 Cells via the Mitochondrial Pathway
Journal
International Journal of Molecular Sciences
Fascaplysin Induces Apoptosis and Ferroptosis, and Enhances Anti-PD-1 Immunotherapy in Non-Small Cell Lung Cancer (NSCLC) by Promoting PD-L1 Expression - PMC
Journal
International journal of molecular sciences
Species
Homo sapiens, Mus musculus
HDAC8-Selective Inhibition by PCI-34051 Enhances the Anticancer Effects of ACY-241 in Ovarian Cancer Cells - PMC
Journal
International journal of molecular sciences
The Extracts of Dendrobium Alleviate Dry Eye Disease in Rat Model by Regulating Aquaporin Expression and MAPKs/NF-κB Signalling - PMC
Journal
International journal of molecular sciences
Artemisinin suppresses hepatocellular carcinoma cell growth, migration andinvasion bytargeting cellular bioenergetics andHippoYAP signaling
Journal
Archives of toxicology
Species
Homo sapiens, Mus musculus
FSBP suppresses tumor cell migration by inhibiting the JNK pathway - PMC
Periplocin targets low density lipoprotein receptor-related protein 4 to attenuate osteoclastogenesis and protect against osteoporosis
Journal
Biochemical pharmacology
N-3, a novel synthetic derivative of bifendate, inhibits metastasis of triple-negative breast cancer via decreasing p38-regulated FOXC1 protein stability
Journal
Biochemical pharmacology
Species
Homo sapiens, Mus musculus
Biomimetic Cucurbitacin B-Polydopamine Nanoparticles for Synergistic Chemo-Photothermal Therapy of Breast Cancer
Journal
Frontiers in bioengineering and biotechnology
Manganese-Based Prussian Blue Nanocatalysts Suppress Non-Small Cell Lung Cancer Growth and Metastasis via Photothermal and Chemodynamic Therapy - PMC
Journal
Frontiers in bioengineering and biotechnology
The Imbalance of MMP-2/TIMP-2 and MMP-9/TIMP-1 Contributes to Collagen Deposition Disorder in Diabetic Non-Injured Skin
Journal
Front Endocrinol (Lausanne)
15, 16-Dihydrotanshinone I Inhibits Hemangiomas through Inducing Pro-apoptotic and Anti-angiogenic Mechanisms in Vitro and in Vivo.
Journal
Frontiers in Pharmacology
A Chinese Herbal Formula Suppresses Colorectal Cancer Migration and Vasculogenic Mimicry Through ROS/HIF-1α/MMP2 Pathway in Hypoxic Microenvironment.
Journal
Frontiers in Pharmacology
The role played by ailanthone in inhibiting bone metastasis of breast cancer by regulating tumor-bone microenvironment through the RANKL-dependent pathway - PMC
Journal
Frontiers in pharmacology
A Novel Rhamnoside Derivative PL402 Up-Regulates Matrix Metalloproteinase 3/9 to Promote Aβ Degradation and Alleviates Alzheimer's-like Pathology.
Reduced miR-203 predicts metastasis and poor survival in esophageal carcinoma.
Overexpression of MEF2D contributes to oncogenic malignancy and chemotherapeutic resistance in ovarian carcinoma.
Journal
American journal of cancer research
Exploring the Mechanism of Hawthorn Leaves Against Coronary Heart Disease Using Network Pharmacology and Molecular Docking - PMC
Journal
Frontiers in cardiovascular medicine
Byakangelicol suppresses TiPs-stimulated osteoclastogenesis and bone destruction via COX-2/NF-B signaling pathway
Journal
Regenerative biomaterials
Myricetin Suppresses Ovarian Cancer In Vitro by Activating the p38/Sapla Signaling Pathway and Suppressing Intracellular Oxidative Stress
Journal
Frontiers in oncology
Activation of AMP-activated protein kinase ablated the formation of aortic dissection by suppressing vascular inflammation and phenotypic switching of vascular
Journal
International immunopharmacology
USP43 impairs cisplatin sensitivity in epithelial ovarian cancer through HDAC2-dependent regulation of Wnt/-catenin signaling pathway
Journal
Apoptosis : an international journal on programmed cell death
PPy@Fe 3 O 4 Nanoparticles Inhibit Tumor Growth and Metastasis Through Chemodynamic and Photothermal Therapy in Non-small Cell Lung Cancer
Exogenous Klotho ameliorates extracellular matrix degradation and angiogenesis in intervertebral disc degeneration via inhibition of the Rac1/PAK1/MMP-2 signaling
Journal
Mechanisms of ageing and development
Species
Homo sapiens,Rattus norvegicus
The F-Box/DUF295 Brassiceae specific 2 is involved in ABA-inhibited seed germination and seedling growth in Arabidopsis
Journal
Plant science : an international journal of experimental plant biology
Species
Arabidopsis thaliana
Piperine Reduces Neoplastic Progression in Cervical Cancer Cells by Downregulating the Cyclooxygenase 2 Pathway
Journal
Pharmaceuticals (Basel, Switzerland)
Hepatoprotective effect of total flavonoids of Mallotus apelta (Lour.) Muell.Arg. leaf against carbon tetrachloride-induced liver fibrosis in rats via modulation of TGF-β1/Smad and NF-κB signaling pathways
Journal
Journal of ethnopharmacology
GJ-4 ameliorates memory impairment in focal cerebral ischemia/reperfusion of rats via inhibiting JAK2/STAT1-mediated neuroinflammation
Heme oxygenase 1 linked to inactivation of subchondral osteoclasts in osteoarthritis - PMC
Journal
Journal of Zhejiang University. Science. B
Endothelial Cell-Specific Molecule 1 Promotes Endothelial to Mesenchymal Transition in Renal Fibrosis
Talin2 mediates secretion and trafficking of matrix metallopeptidase 9 during invadopodium formation
Journal
Biochimica et Biophysica acta. Molecular Cell Research
Single-cell sequencing reveals the impact of endothelial cell PIEZO1 expression on thoracic aortic aneurysm
Journal
Journal of molecular and cellular cardiology
Suramin inhibits phenotypic transformation of vascular smooth muscle cells and neointima hyperplasia by suppressing transforming growth factor beta receptor 1
Journal
European journal of pharmacology
Species
Homo sapiens,Mus musculus
Kaempferol suppresses glioma progression and synergistically enhances the antitumor activity of gefitinib by inhibiting the EGFR/SRC/STAT3 signaling pathway
Journal
Drug development research
Receptor-interacting serine/threonine kinase 1- and 3-dependent inflammation induced in lungs of chicken infected with Pasteurella multocida
Journal
Scientific Reports
Periodontal ligament cells-derived exosomes promote osteoclast differentiation via modulating macrophage polarization - PMC
Journal
Scientific reports
Inhibitory effects of Schisandrin C on collagen behavior in pulmonary fibrosis - PMC
Journal
Scientific reports
The Inhibition of Gastric Cancer Cells' Progression by 23,24-Dihydrocucurbitacin E through Disruption of the Ras/Raf/ERK/MMP9 Signaling Pathway
Journal
Molecules (Basel, Switzerland)
N4BP1 regulates keratinocytes development and plays protective role in burn-and adhesive-related skin injury via MMP9
Journal
Cellular signalling
Species
Homo sapiens, Mus musculus
LncRNA-HOXC-AS2 regulates tumor-associated macrophage polarization through the STAT1/SOCS1 and STAT1/CIITA pathways to promote the progression of non
Journal
Cellular signalling
DHCR7 promotes tumorigenesis via activating PI3K/AKT/mTOR signalling pathway in bladder cancer
Journal
Cellular Signalling
Impact of Aβ40 and Aβ42 Fibrils on the Transcriptome of Primary Astrocytes and Microglia - PMC
Anti-migratory Properties of Cryoprotective Isoliquiritigenin-zein Phosphatidylcholine Nanoparticles Prevent Triple-negative Breast Cancer through PI3K-mTOR and
Journal
Current medicinal chemistry
β-Elemene induces apoptosis by activating the P53 pathway in human hypertrophic scar fibroblasts
Ubiquitin-specific protease-44 inhibits the proliferation and migration of cells via inhibition of JNK pathway in clear cell renal cell carcinoma
Systematic analysis of the role of LDHs subtype in pan-cancer demonstrates the importance of LDHD in the prognosis of hepatocellular carcinoma patients - PMC
LukS-PV inhibits hepatocellular carcinoma cells migration by downregulating HDAC6 expression - PMC
Legumain Inhibitor Prevents Breast Cancer Bone Metastasis by Attenuating Osteoclast Differentiation and Function
Species
Homo sapiens, Mus musculus
Subacute cadmium exposure promotes M1 macrophage polarization through oxidative stress-evoked inflammatory response and induces porcine adrenal fibrosis
Inhibitory Effect of Jinwujiangu Prescription on Peripheral Blood Osteoclasts in Patients with Rheumatoid Arthritis and the Relevant Molecular Mechanism - PMC
Journal
Mediators of inflammation
Differential expression of microRNAs in human endometrium after implantation of an intrauterine contraceptive device containing copper
Journal
Molecular human reproduction
MMP9 and IGFBP1 Regulate Tumor Immune and Drive Tumor Progression in Clear Cell Renal Cell Carcinoma
PRMT7 Inhibits the Proliferation and Migration of Gastric Cancer Cells by Suppressing the PI3K/AKT Pathway via PTEN
Improvement of vaginal probiotics Lactobacillus crispatus on intrauterine adhesion in mice model and in clinical practice - PMC
Protective Effect of Anwulignan on Gastric Injury Induced by Indomethacin in Mice
Journal
The Journal of pharmacology and experimental therapeutics
LukS-PV Inhibits Hepatocellular Carcinoma Cells Migration via the TNNC1/PI3K/AKT Axis
Chlorogenic Acid Inhibits Human Glioma U373 Cell Progression via Regulating the SRC/MAPKs Signal Pathway: Based on Network Pharmacology Analysis
Journal
Drug Des Devel Ther
N-Acetyl-l-Leucine-Polyethyleneimine-Mediated Delivery of CpG Oligodeoxynucleotides 2006 Inhibits RAW264. 7 Cell Osteoclastogenesis
Journal
Drug Des Devel The
Deubiquitinating enzyme PSMD14 facilitates gastric carcinogenesis through stabilizing PTBP1
Journal
Experimental cell research
Ubiquitin specific peptidase 19 is a prognostic biomarker and affect the proliferation and migration of clear cell renal cell carcinoma
Berberine ameliorates nonalcoholic fatty liver disease-induced bone loss by inhibiting ferroptosis
Corosolic acid inhibits metastatic response of human renal cell carcinoma cells by modulating ERK/MMP2 signaling
Journal
Environmental toxicology
Enhanced Extracellular Matrix Degradation in Growth Plate Contributes to Manganese Deficiency-Induced Tibial Dyschondroplasia in Broiler Chicks
Journal
Biol Trace Elem Res
miR‐450b promotes cell migration and invasion by inhibiting SERPINB2 in oral squamous cell carcinoma
In vivo and in vitro efficacy of crocin against Echinococcus multilocularis
Species
Echinococcus multilocularis
CpG oligodeoxynucleotides inhibit the proliferation and osteoclastic differentiation of RAW264. 7 cells
Ligusticum chuanxiong promotes the angiogenesis of preovulatory follicles (F1-F3) in late-phase laying hens
SIAH1 facilitates the migration and invasion of gastric cancer cells through promoting the ubiquitination and degradation of RECK - PMC
Berberine inhibits IL-21/IL-21R mediated inflammatory proliferation of fibroblast-like synoviocytes through the attenuation of PI3K/Akt signaling pathway and
Analysis of m6A-related lncRNAs for prognostic and immunotherapeutic response in hepatocellular carcinoma - PMC
Xinmai 'an extract enhances the efficacy of sildenafil in the treatment of pulmonary arterial hypertension via inhibiting MAPK signalling pathway
Journal
Pharmaceutical biology
5-Methoxytryptophan enhances the sensitivity of sorafenib on the inhibition of proliferation and metastasis for lung cancer cells - PMC
Exosomal LRG1 promotes non-small cell lung cancer proliferation and metastasis by binding FN1 protein
Journal
Experimental cell research
Network pharmacology and experimental verification to decode the action of Qing Fei Hua Xian Decotion against pulmonary fibrosis - PMC
Pyroptosis inhibitors MCC950 and VX-765 mitigate myocardial injury by alleviating oxidative stress, inflammation, and apoptosis in acute myocardial hypoxia
Journal
Experimental cell research
Upregulation of matrix metalloproteinase-9/2 in the wounded tissue, dorsal root ganglia, and spinal cord is involved in the development of postoperative pain.
Inflammation plays a critical role in damage to the bronchiolar epithelium induced by Trueperella pyogenes in vitro and in vivo
Journal
Infection and immunity
Exogenous Spermidine Alleviates Diabetic Myocardial Fibrosis Via Suppressing Inflammation and Pyroptosis in db/db Mice - PMC
Journal
Balkan medical journal
LINC00667 Promotes Progression of Esophageal Cancer Cells by Regulating miR-200b-3p/SLC2A3 Axis
Journal
Digestive diseases and sciences
MMP2 and MMP9 contribute to lung ischemia-reperfusion injury via promoting pyroptosis in mice - PMC
Journal
BMC pulmonary medicine
Curcuma longa L. extract exhibits anti-inflammatory and cytoprotective functions in the articular cartilage of monoiodoacetate-injected rats
Journal
Food & nutrition research
Microcyst fluid promotes the migration and invasion of fibroblasts in the adventitial layer of alveolar echinococcosis
Orientin regulates the proliferation and migration of hepatocellular carcinoma cells
Journal
Naunyn-Schmiedeberg's archives of pharmacology
A critical influence of HIF-1 on MMP-9 and Galectin-3 in oral lichen planus - PMC
Efficacy and Safety of Asparagusic Acid against Echinococcus multilocularis In Vitro and in a Murine Infection Model - PMC
Journal
Tropical medicine and infectious disease
Knockdown of CD44 inhibits proliferation, migration and invasion of osteosarcoma cells accompanied by downregulation of cathepsin S
Journal
Journal of orthopaedic surgery and research
Flavonoid Extract from Propolis Inhibits Cardiac Fibrosis Triggered by Myocardial Infarction through Upregulation of SIRT1.
Journal
Evidence-based Complementary and Alternative Medicine
GSPT1 Functions as a Tumor Promoter in Human Liver Cancer
Journal
Current medical science
PRG4 represses the genesis and metastasis of osteosarcoma by inhibiting PDL1 expression
Species
Homo sapiens,Mus musculus
Effects of low level laser on periodontal tissue remodeling in hPDLCs under tensile stress - PMC
Journal
Lasers in medical science
ELK3 Targeting AEG1 Promotes Migration and Invasion of Ovarian Cancer Cells under Hypoxia
Journal
Biological & pharmaceutical bulletin
TLR9 Exerts an Oncogenic Role in Promoting Osteosarcoma Progression Depending on the Regulation of NF-κB Signaling Pathway
Journal
Biological & pharmaceutical bulletin
RP11-79H23. 3 Inhibits the Proliferation and Metastasis of Non-small-cell Lung Cancer Through Promoting miR-29c
Journal
Biochemical genetics
Effect of black cloth ointment on hypertrophic scar formation: An investigation using integrated network pharmacology and animal assay - PMC
Journal
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
The role of necroptosis, apoptosis, and inflammation in fowl cholera–associated liver injury in a chicken model
Evaluation of Allicin Against Alveolar Echinococcosis In Vitro and in a Mouse Model
TRPA1 aggravates osteoclastogenesis and osteoporosis through activating endoplasmic reticulum stress mediated by SRXN1 - PMC
Journal
Cell death & disease
Inhibition of TRPV4 remodels single cell polarity and suppresses the metastasis of hepatocellular carcinoma - PMC
Journal
Cell death & disease
The m6A modification-mediated OGDHL exerts a tumor suppressor role in ccRCC by downregulating FASN to inhibit lipid synthesis and ERK signaling - PMC
Journal
Cell death & disease
The alternative splicing of intersectin 1 regulated by PTBP1 promotes human glioma progression - PMC
Journal
Cell death & disease
Multifunctional Biodegradable Prussian Blue Analogue for Synergetic Photothermal/Photodynamic/Chemodynamic Therapy and Intrinsic Tumor Metastasis Inhibition
Journal
ACS applied bio materials