Fecal microbiota transplantation protects rotenone-induced Parkinson's disease mice via suppressing inflammation mediated by the lipopolysaccharide-TLR4 …
Single-cell analyses reveal cannabidiol rewires tumor microenvironment via inhibiting alternative activation of macrophage and synergizes with anti-PD-1 in …
Journal
Journal of pharmaceutical analysis
Identification of potential anti-pneumonia pharmacological components of Glycyrrhizae Radix et Rhizoma after the treatment with Gan An He Ji oral liquid
Journal
Journal of pharmaceutical analysis
Sulforaphane attenuates microglia-mediated neuronal necroptosis through down-regulation of MAPK/NF-B signaling pathways in LPS-activated BV-2 microglia
Journal
Pharmacological Research
Zinc oxide nanoparticles exacerbate skin epithelial cell damage by upregulating pro-inflammatory cytokines and exosome secretion in M1 macrophages following UVB irradiation-induced skin injury - PMC
Journal
Particle and fibre toxicology
Pyruvate Kinase M2 Promotes the Activation of Dendritic Cells by Enhancing IL-12p35 Expression
Critical contributions of protein cargos to the functions of macrophage-derived extracellular vesicles - PMC
Journal
Journal of nanobiotechnology
Endothelial MICU1 alleviates diabetic cardiomyopathy by attenuating nitrative stress-mediated cardiac microvascular injury - PMC
Journal
Cardiovascular diabetology
Digoxin protects against intervertebral disc degeneration via TNF/NF-B and LRP4 signaling - PMC
Journal
Frontiers in immunology
Antibody-Mediated LILRB2-Receptor Antagonism Induces Human Myeloid-Derived Suppressor Cells to Kill Mycobacterium tuberculosis - PMC
Journal
Frontiers in immunology
Host MKRN1-Mediated Mycobacterial PPE Protein Ubiquitination Suppresses Innate Immune Response
Journal
Frontiers in immunology
Pou3f1 mediates the effect of Nfatc3 on ulcerative colitis-associated colorectal cancer by regulating inflammation - PMC
Journal
Cellular & molecular biology letters
BMSC-derived exosomes promote tendon-bone healing after anterior cruciate ligament reconstruction by regulating M1/M2 macrophage polarization in rats - PMC
Journal
Stem cell research & therapy
Targeting antioxidant factor Nrf2 by raffinose ameliorates lipid dysmetabolism-induced pyroptosis, inflammation and fibrosis in NAFLD
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Discovery of Novel Pterostilbene Derivatives That Might Treat Sepsis by Attenuating Oxidative Stress and Inflammation through Modulation of MAPKs/NF-κB Signaling Pathways
Journal
Antioxidants (Basel)
Discovery of a novel cyclin-dependent kinase 8 inhibitor with an oxindole core for anti-inflammatory treatment
Journal
Biomed Pharmacother
Species
Homo sapiens, Mus musculus
Isoliquiritigenin inhibits apoptosis and ameliorates oxidative stress in rheumatoid arthritis chondrocytes through the Nrf2/HO-1-mediated pathway
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Standardized extract of Glehnia Littoralis abrogates memory impairment and neuroinflammation by regulation of CREB/BDNF and NF-B/MAPK signaling in
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Membrane vesicles from Lactobacillus johnsonii delay osteoarthritis progression via modulating macrophage glutamine synthetase/mTORC1 axis
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
κ-Opioid Receptors Improve Vascular Endothelial Dysfunction in Salt-Sensitive Hypertension via PI3K/Akt/eNOS Signaling Pathway - PMC
Journal
Oxidative medicine and cellular longevity
The oxidant-antioxidant imbalance was involved in the pathogenesis of chronic rhinosinusitis with nasal polyps - PMC
Journal
Frontiers in immunology
STING/NF-B/IL-6-Mediated Inflammation in Microglia Contributes to Spared Nerve Injury (SNI)-Induced Pain Initiation
Journal
J Neuroimmune Pharmacol
Design, synthesis, and SAR study of novel 4,5-dihydropyrazole-Thiazole derivatives with anti-inflammatory activities for the treatment of sepsis
Synthesis of 1, 3, 5-Triphenyl-1, 2, 4-Triazole Derivatives and Their Neuroprotection by Anti-Oxidative Stress and Anti-Inflammation and Protecting BBB
Journal
European journal of medicinal chemistry
Chronic sleep fragmentation shares similar pathogenesis with neurodegenerative diseases: Endosome-autophagosome-lysosome pathway dysfunction and microglia-mediated neuroinflammation.
Journal
CNS Neuroscience & Therapeutics
Timosaponin B-II alleviates osteoarthritis-related inflammation and extracellular matrix degradation through inhibition of mitogen-activated protein kinases and nuclear factor-κB pathways in vitro
The neuroprotective effects of caffeic acid phenethyl ester against methamphetamine-induced neurotoxicity
Journal
Ecotoxicology and environmental safety
Anti-Inflammatory and Antioxidant Effects of Anthocyanins of Trifolium pratense (Red Clover) in Lipopolysaccharide-Stimulated RAW-267.4 Macrophages
Species
Trifolium pratense
Enhanced therapeutic efficacy of a novel colon-specific nanosystem loading emodin on DSS-induced experimental colitis
Protective effects of E Se tea extracts against alcoholic fatty liver disease induced by high fat/alcohol diet: In vivo biological evaluation and molecular docking study
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Integrated multi-omics reveal important roles of gut contents in intestinal ischemia-reperfusion induced injuries in rats - PMC
Journal
Communications biology
Design of Targeted Flurbiprofen Biomimetic Nanoparticles for Management of Arthritis: In Vitro and In Vivo Appraisal
Dapagliflozin Mitigates Hypotension in Lipopolysaccharide-Induced Acute Inflammation Independent of Glycemia Level - PMC
Indole-3-propionic acid alleviates chondrocytes inflammation and osteoarthritis via the AhR/NF-κB axis - PMC
Journal
Molecular medicine (Cambridge, Mass.)
Investigation of the active components and mechanisms of Schisandra chinensis in the treatment of asthma based on a network pharmacology approach and experimental validation
Species
Rattus norvegicus,Schisandra chinensis
Inducible Nitric Oxide Synthase (iNOS) Mediates Vascular Endothelial Cell Apoptosis in Grass Carp Reovirus (GCRV)-Induced Hemorrhage.
Journal
International Journal of Molecular Sciences
Species
Ctenopharyngodon idellus
Endothelial Mitochondria Transfer to Melanoma Induces M2-Type Macrophage Polarization and Promotes Tumor Growth by the Nrf2/HO-1-Mediated Pathway - PMC
Journal
International journal of molecular sciences
Dioscorea nipponica Makino Rhizome Extract and Its Active Compound Dioscin Protect against Neuroinflammation and Scopolamine-Induced Memory Deficits - PMC
Journal
International journal of molecular sciences
Cold Stress Induced Liver Injury of Mice through Activated NLRP3/Caspase-1/GSDMD Pyroptosis Signaling Pathway - PMC
Bilobalide Exerts Anti-Inflammatory Effects on Chondrocytes Through the AMPK/SIRT1/mTOR Pathway to Attenuate ACLT-Induced Post-Traumatic Osteoarthritis in Rats
Journal
Frontiers in pharmacology
MiR-144-5p limits experimental abdominal aortic aneurysm formation by mitigating M1 macrophage-associated inflammation: Suppression of TLR2 and OLR1
Journal
Journal of Molecular and Cellular Cardiology
Stemona alkaloids suppress the positive feedback loop between M2 polarization and fibroblast differentiation by inhibiting JAK2/STAT3 pathway in fibroblasts and CXCR4/PI3K/AKT1 pathway in macrophages.
Journal
International immunopharmacology
Thymopentin (TP-5) prevents lipopolysaccharide-induced neuroinflammation and dopaminergic neuron injury by inhibiting the NF-κB/NLRP3 signaling pathway
Journal
International immunopharmacology
Nuciferine alleviates intestinal inflammation by inhibiting MAPK/NF-κB and NLRP3/Caspase 1 pathways in vivo and in vitro
Journal
International immunopharmacology
Anti-Neuroinflammatory Effect of Ombuin from Rhamnus erythroxylon Pall. Leaves in LPS-Induced BV-2 Microglia by Targeting Src and Suppressing the PI3K-AKT/NF-B Signaling Pathway - PMC
Journal
International journal of molecular sciences
Quercetin Modulates Ferroptosis via the SIRT1/Nrf-2/HO-1 Pathway and Attenuates Cartilage Destruction in an Osteoarthritis Rat Model - PMC
Journal
International journal of molecular sciences
Indole-3-aldehyde alleviates chondrocytes inflammation through the AhR-NF-B signalling pathway
Journal
International Immunopharmacology
Gypenoside XLIX alleviates acute liver injury: Emphasis on NF-B/PPAR-/NLRP3 pathways
Journal
International immunopharmacology
Systems pharmacology-based dissection of mechanisms of Tibetan medicinal compound Ruteng as an effective treatment for collagen-induced arthritis rats
Journal
Journal of ethnopharmacology
Species
Boswellia carterii
Chinese sumac (Rhus chinensis Mill.) fruits alleviate indomethacin-induced gastric ulcer in mice by improving oxidative stress, inflammation and apoptosis
In vitro and in vivo anti-inflammatory effects of different extracts from Epigynum auritum through down-regulation of NF-κB and MAPK signaling pathways
Mitochondrial Transplantation Attenuates Neural Damage and Improves Locomotor Function After Traumatic Spinal Cord Injury in Rats
Journal
Frontiers in neuroscience
Activation of ovarian taste receptors inhibits progesterone production potentially via NO/cGMP and apoptotic signaling
Naringin Exhibited Therapeutic Effects against DSS-Induced Mice Ulcerative Colitis in Intestinal Barrier-Dependent Manner
Molecular Cloning, Expression and Macrophage Activation of an Immunoregulatory Protein from Cordyceps militaris
Species
Cordyceps militaris
DDAH-1 via HIF-1 target genes improves cerebral ischemic tolerance after hypoxic preconditioning and middle cerebral artery occlusion-reperfusion
Journal
Nitric Oxide : Biology and Chemistry
Limonin delays the progression of intervertebral disc degeneration in vivo and in vitro: the key role of the MAPK/NF-B and necroptosis pathways
Journal
The Journal of pharmacy and pharmacology
Depletion of regulatory T cells exacerbates inflammatory responses after chronic cerebral hypoperfusion in mice
Journal
Molecular and cellular neurosciences
Dauricine negatively regulates lipopolysaccharide- or cecal ligation and puncture-induced inflammatory response via NF-κB inactivation.
Journal
Archives of biochemistry and biophysics
Tectoridin alleviates caerulein-induced severe acute pancreatitis by targeting ERK2 to promote macrophage M2 polarization
Journal
Archives of biochemistry and biophysics
Participation of follicular superoxides, inflammatory modulators, and endocrine factors in zebrafish (Danio rerio) ovulation: Cross-talk between PKA and MAPK
Journal
Molecular and cellular endocrinology
Fetuin-A regulates adipose tissue macrophage content and activation in insulin resistant mice through MCP-1 and iNOS: Involvement of IFNγ-JAK2-STAT1 pathway
Irf6 participates in sevoflurane-induced perioperative neurocognitive disorder via modulating M2, but not M1 polarization of microglia
Fingolimod promotes angiogenesis and attenuates ischemic brain damage via modulating microglial polarization
TREM2 Overexpression Attenuates Cognitive Deficits in Experimental Models of Vascular Dementia
18: 0 Lyso PC, a natural product with potential PPAR-γ agonistic activity, plays hypoglycemic effect with lower liver toxicity and cardiotoxicity in db/db mice
Journal
Biochem Biophys Res Commun
Quercetin ameliorates memory impairment by inhibiting abnormal microglial activation in a mouse model of paradoxical sleep deprivation
Journal
Biochemical and biophysical research communications
KDM4A, involved in the inflammatory and oxidative stress caused by traumatic brain injury-hemorrhagic shock, partly through the regulation of the microglia M1 polarization - PMC
Suffrutines A and B Inhibit the Expression of Inflammatory Mediators in LPS-Induced RAW264. 7 Cells by Suppressing the NF-B Signaling Pathway
Lycium barbarum polysaccharide attenuates cardiac hypertrophy, inhibits calpain-1 expression and inhibits NF-κB activation in streptozotocin-induced diabetic rats.
Journal
Experimental and therapeutic medicine
Arctiin alleviates functional constipation by enhancing intestinal motility in mice - PMC
Journal
Experimental and therapeutic medicine
Zhikang Capsule Ameliorates Inflammation, Drives Polarization to M2 Macrophages, and Inhibits Apoptosis in Lipopolysaccharide-induced RAW264. 7 Cells
Journal
Current medical science
Transcriptomics-based exploration of shared M1-type macrophage-related biomarker in acute kidney injury after kidney transplantation and acute rejection after
Journal
Transplant immunology
Nitric oxide inhibits ten-eleven translocation DNA demethylases to regulate 5mC and 5hmC across the genome - PMC
Dangui Huoxue Preparation (DHP) Ameliorates Skin Fibrosis, Inflammation, and Vasculopathy in the BleomycinInduced Murine Model of Systemic Sclerosis