Amelioration of Alzheimer's disease pathology by mitophagy inducers identified via machine learning and a cross-species workflow
Journal
Nature biomedical engineering
Species
Homo sapiens, Mus musculus
Naked mole-rat brown fat thermogenesis is diminished during hypoxia through a rapid decrease in UCP1
Influenza M2 protein regulates MAVS-mediated signaling pathway through interacting with MAVS and increasing ROS production
Optimized allotopic expression of mitochondrial ND6 transgene restored complex I and apoptosis deficiencies caused by LHON-linked ND6 14484T>C mutation - PMC
Journal
Journal of biomedical science
Activation of Ca2+ phosphatase Calcineurin regulates Parkin translocation to mitochondria and mitophagy in flies - PMC
Journal
Cell death and differentiation
Metabolite Neu5Ac triggers SLC3A2 degradation promoting vascular endothelial ferroptosis and aggravates atherosclerosis progression in ApoE-/-mice - PMC
Activation of TFEB-mediated autophagy by trehalose attenuates mitochondrial dysfunction in cisplatin-induced acute kidney injury.
Species
Homo sapiens, Mus musculus
Lycopene mitigates DEHP-induced hepatic mitochondrial quality control disorder via regulating SIRT1/PINK1/mitophagy axis and mitochondrial unfolded protein response
Mitochondrial dynamics and mitophagy involved in MPA-capped CdTe quantum dots-induced toxicity in the human liver carcinoma (HepG2) cell line
Journal
Environmental pollution (Barking, Essex : 1987)
Mitophagy bridges DNA sensing with metabolic adaption to expand lung cancer stemlike cells
Altered synaptic currents, mitophagy, mitochondrial dynamics in Alzheimer's disease models and therapeutic potential of Dengzhan Shengmai Capsules
Journal
Journal of pharmaceutical analysis
The crosstalk between DRP1-dependent mitochondrial fission and oxidative stress triggers hepatocyte apoptosis induced by silver nanoparticles
Species
Mus musculus, Homo sapiens
Oyster (Crassostrea gigas) ferritin relieves lead-induced liver oxidative damage via regulating the mitophagy
Journal
International journal of biological macromolecules
Genetic and pharmacological targeting of XBP1 alleviates hepatic ischemia reperfusion injury by enhancing FoxO1-dependent mitophagy
Journal
Translational research : the journal of laboratory and clinical medicine
Maintaining the Mitochondrial Quality Control System Was a Key Event of Tanshinone IIA against Deoxynivalenol-Induced Intestinal Toxicity - PMC
Journal
Antioxidants (Basel, Switzerland)
DEK deficiency suppresses mitophagy to protect against house dust mite-induced asthma - PMC
Journal
Frontiers in immunology
Mitophagy–lysosomal pathway is involved in silver nanoparticle-induced apoptosis in A549 cells
Journal
Ecotoxicol Environ Saf
Platycodon grandifloras polysaccharides inhibit mitophagy injury induced by Cr (VI) in DF-1 cells
Journal
Ecotoxicol Environ Saf
7,8-Dihydroxyflavone ameliorates mitochondrial impairment and motor dysfunction in the α-synuclein 1-103 transgenic mice
Journal
Neurobiology of disease
Mitophagy protects against silver nanoparticleinduced hepatotoxicity by inhibiting mitochondrial ROS and the NLRP3 inflammasome
Journal
Ecotoxicology and environmental safety
Dapagliflozin improves diabetic cognitive impairment via indirectly modulating the mitochondria homeostasis of hippocampus in diabetic mice
Journal
BioFactors (Oxford, England)
DYNLT1 promotes mitochondrial metabolism to fuel breast cancer development by inhibiting ubiquitination degradation of VDAC1 - PMC
Journal
Molecular medicine (Cambridge, Mass.)
Ameliorative effects of resveratrol against cadmium-induced nephrotoxicity via modulating nuclear xenobiotic receptor response and PINK1/Parkin-mediated Mitophagy
Deficient tRNA posttranscription modification dysregulated the mitochondrial quality controls and apoptosis - PMC
Exposure effects of inhaled nickel nanoparticles on the male reproductive system via mitochondria damage
Nobiletin Ameliorates Aging of Chicken Ovarian Prehierarchical Follicles by Suppressing Oxidative Stress and Promoting Autophagy
N-Acetyl Cysteine Ameliorates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease and Intracellular Triglyceride Accumulation by Preserving Mitochondrial Function
Breviscapine remodels myocardial glucose and lipid metabolism by regulating serotonin to alleviate doxorubicin-induced cardiotoxicity - PMC
Journal
Frontiers in pharmacology
PINK1/Parkin-Mediated Mitophagy Plays a Protective Role in the Bone Impairment Caused by Aluminum Exposure
5-Heptadecylresorcinol Ameliorates Obesity-Associated Skeletal Muscle Mitochondrial Dysfunction through SIRT3-Mediated Mitophagy
Journal
Journal of agricultural and food chemistry
Folic Acid Protects against Ethanol-Induced Hepatic Mitophagy Imbalance by ROS Scavenging and Attenuating the Elevated Hcy Levels
Journal
Journal of agricultural and food chemistry
Arsenic Exposure-Induced Acute Kidney Injury by Regulating SIRT1/PINK1/Mitophagy Axis in Mice and in HK-2 Cells
Journal
Journal of agricultural and food chemistry
Hypoglycemic Effect of Nobiletin via Regulation of Islet β-Cell Mitophagy and Gut Microbiota Homeostasis in Streptozocin-Challenged Mice
Journal
Journal of agricultural and food chemistry
Sesamin Alleviates Asthma Airway Inflammation by Regulating Mitophagy and Mitochondrial Apoptosis
Journal
Journal of agricultural and food chemistry
Sesamin Alleviates Asthma Airway Inflammation by Regulating Mitophagy and Mitochondrial Apoptosis
Journal
Journal of agricultural and food chemistry
Polydatin inhibits mitochondrial damage and mitochondrial ROS by promoting PINK1‐Parkin‐mediated mitophagy in allergic rhinitis
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Radiation resistance of cancer cells caused by mitochondrial dysfunction depends on SIRT3mediated mitophagy
The autophagic regulation of rosiglitazone-promoted adipocyte browning - PMC
Journal
Frontiers in pharmacology
Silver nanoparticles induced hippocampal neuronal damage involved in mitophagy, mitochondrial biogenesis and synaptic degeneration
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Parecoxib alleviates the motor behavioral decline of aged rats by ameliorating mitochondrial dysfunction in the substantia nigra via COX-2/PGE2 pathway inhibition
Leber's hereditary optic neuropathy (LHON)-associated ND6 14 484 T > C mutation caused pleiotropic effects on the complex I, RNA homeostasis, apoptosis and mitophagy
Journal
Human molecular genetics
Exogenous H2S alleviates senescence of glomerular mesangial cells through up-regulating mitophagy by activation of AMPK-ULK1-PINK1-parkin pathway in mice
Journal
Biochimica et biophysica acta. Molecular cell research
ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts.
Journal
Scientific Reports
Exploring the novel benefits of leucine: protecting nitrite-induced liver damage in sub-adult grass carp (Ctenopharyngodon idella) through regulating mitochondria
Journal
Fish & shellfish immunology
Dimethoxytolyl propylresorcinol induces apoptosis and mitophagy in human leukemia cells through the PI3K/AKT pathway - PMC
Species
Dianella ensifolia,Homo sapiens
Mitophagy Induced by Mitochondrial Function Damage in Chicken Kidney Exposed to Cr(VI)
Journal
Biol Trace Elem Res
Inflammatory Injury and Mitophagy in the Cock Heart Induced by the Oral Administration of Hexavalent Chromium
Journal
Biol Trace Elem Res
The Protective Effect of Lycium Ruthenicum Murr Anthocyanins in Cr (VI)-Induced Mitophagy in DF-1 Cells - PMC
Journal
Life (Basel, Switzerland)
Reduced expression of NUPR1 alleviates epilepsy progression via attenuating ER stress
Journal
Biochemical and biophysical research communications
Aflatoxin B1 induces ROSdependent mitophagy by modulating the PINK1/Parkin pathway in HepG2 cells
Journal
Basic & clinical pharmacology & toxicology
Raw Inonotus obliquus polysaccharide counteracts Alzheimer's disease in a transgenic mouse model by activating the ubiquitin-proteosome system
Journal
Nutrition research and practice
High Autophagy Patterns in Swelling Platelets During Apheresis Platelet Storage
Journal
Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion
Deafness-associated tRNAPhe mutation impaired mitochondrial and cellular integrity - PMC
Journal
The Journal of biological chemistry
Obesity impairs cardiolipin-dependent mitophagy and therapeutic intercellular mitochondrial transfer ability of mesenchymal stem cells - PMC
Journal
Cell death & disease
Species
Homo sapiens, Mus musculus