Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T-cell Leukemogenesis
Tailored Apoptotic Vesicle Delivery Platform for Inflammatory Regulation and Tissue Repair to Ameliorate Ischemic Stroke
Bioactive Ceria Nanoenzymes Target Mitochondria in Reperfusion Injury to Treat Ischemic Stroke
The role of altered lipid composition and distribution in liver fibrosis revealed by multimodal nonlinear optical microscopy - PMC
Cholesterol-associated lysosomal disorder triggers cell death of hematological malignancy: Dynamic analysis on cytotoxic effects of LW-218
Astaxanthine attenuates cisplatin ototoxicity in vitro and protects against cisplatin-induced hearing loss in vivo
Journal
Acta pharmaceutica Sinica. B
Eubacterium coprostanoligenes alleviates chemotherapy-induced intestinal mucositis by enhancing intestinal mucus barrier
Journal
Acta pharmaceutica Sinica. B
Periplocin suppresses the growth of colorectal cancer cells by triggering LGALS3 (galectin 3)-mediated lysophagy
LT-171-861, a novel FLT3 inhibitor, shows excellent preclinical efficacy for the treatment of FLT3 mutant acute myeloid leukemia
Species
Homo sapiens, Mus musculus
A novel kinase inhibitor, LZT-106, downregulates Mcl-1 and sensitizes colorectal cancer cells to BH3 mimetic ABT-199 by targeting CDK9 and GSK-3β signaling
Klotho inhibits renal ox-LDL deposition via IGF-1R/RAC1/OLR1 signaling to ameliorate podocyte injury in diabetic kidney disease - PMC
Journal
Cardiovascular diabetology
Inhibition of mitochondrial fusion via SIRT1/PDK2/PARL axis breaks mitochondrial metabolic plasticity and sensitizes cancer cells to glucose restriction
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
The long coiled-coil protein NECC2 regulates oxLDL-induced endothelial oxidative damage and exacerbates atherosclerosis development in apolipoprotein E
Journal
Free radical biology & medicine
Species
Homo sapiens,Mus musculus
Induction of cell cycle arrest and apoptosis by CPUC002 through stabilization of p53 and suppression of STAT3 signaling pathway in multiple myeloma
Effects of natural 24-epibrassinolide on inducing apoptosis and restricting metabolism in hepatocarcinoma cells
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
SIRT1 activation by SRT1720 attenuates bone cancer pain via preventing Drp1-mediated mitochondrial fission.
Journal
Biochimica et biophysica acta. Molecular basis of disease
Novel sequential therapy with metformin enhances the effects of cisplatin in testicular germ cell tumours via YAP1 signalling
Journal
Cancer cell international
Elevated galectin-3 levels detected in women with hyperglycemia during early and mid-pregnancy antagonizes high glucose-induced trophoblast cells apoptosis via galectin-3/foxc1 pathway - PMC
Journal
Molecular medicine (Cambridge, Mass.)
Farrerol Alleviates Myocardial Ischemia/Reperfusion Injury by Targeting Macrophages and NLRP3
Journal
Frontiers in pharmacology
Src‐mediated phosphorylation of GAPDH regulates its nuclear localization and cellular response to DNA damage
GL-V9 inhibits the activation of AR-AKT-HK2 signaling networks and induces prostate cancer cell apoptosis through mitochondria-mediated mechanism - PMC
Isoquercitrin alleviates pirarubicin-induced cardiotoxicity in vivo and in vitro by inhibiting apoptosis through Phlpp1/AKT/Bcl-2 signaling pathway - PMC
Journal
Frontiers in Pharmacology
Species
Homo sapiens,Rattus norvegicus
Glycolysis inhibition and apoptosis induction in human prostate cancer cells by FV-429-mediated regulation of AR-AKT-HK2 signaling network
Ganoderma lucidum extract-mediated gasdermin E cleavage promotes tumor cell pyroptosis and inhibits metastasis in breast cancer
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Species
Homo sapiens, Mus musculus
Tetrahydroalstonine possesses protective potentials on palmitic acid stimulated SK-N-MC cells by suppression of A1-42 and tau through regulation of PI3K/Akt
Journal
European journal of pharmacology
LncRNA FAS-AS1 upregulated by its genetic variation rs6586163 promotes cell apoptosis in nasopharyngeal carcinoma through regulating mitochondria function and Fas splicing - PMC
Journal
Scientific reports
Luteoloside Induces G0/G1 Phase Arrest of Neuroblastoma Cells by Targeting p38 MAPK - PMC
Journal
Molecules (Basel, Switzerland)
Maternal exposure to PM2. 5 decreases ovarian reserve in neonatal offspring mice through activating PI3K/AKT/FoxO3a pathway and ROS-dependent NF-κB pathway
Giardia duodenalis Induces Apoptosis in Intestinal Epithelial Cells via Reactive Oxygen Species-Mediated Mitochondrial Pathway In Vitro
Species
Giardia duodenalis
Increased Mitochondrial Fragmentation Mediated by Dynamin-Related Protein 1 Contributes to Hexavalent Chromium-Induced Mitochondrial Respiratory Chain Complex I-Dependent Cytotoxicity
Lymphatic Metastasis of NSCLC Involves Chemotaxis Effects of Lymphatic Endothelial Cells through the CCR7–CCL21 Axis Modulated by TNF-α
Curcumin enhances anti-ancer efficacy of either gemcitabine or docetaxel on pancreatic cancer cells
Chidamide induces necroptosis via regulation of c‑FLIPL expression in Jurkat and HUT‑78 cells
Journal
Molecular medicine reports
GL-V9 synergizes with oxaliplatin of colorectal cancer via Wee1 degradation mediated by HSP90 inhibition
Journal
The Journal of pharmacy and pharmacology
The role of β-HCG and VEGF-MEK/ERK signaling pathway in villi angiogenesis in patients with missed abortion
LncRNA-SUSAJ1 Activates the ER Stress Pathway Inhibiting JEV Proliferation by Promoting PK15 Cells Apoptosis
Journal
Frontiers in bioscience (Landmark edition)
Species
Sus scrofa,Mesocricetus auratus
Amentoflavone Mitigates Cyclophosphamide-Induced Pulmonary Toxicity: Involvement of -SIRT-1/Nrf2/Keap1 Axis, JAK-2/STAT-3 Signaling, and Apoptosis - PMC
Journal
Medicina (Kaunas, Lithuania)
Hinokitiol Inhibits the Viability of Oral Squamous Carcinoma Cells by Inducing Apoptosis and Autophagy
Journal
Anticancer research
GL-V9 reverses adriamycin resistance in hepatocellular carcinoma cells by affecting JNK2-related autophagy
Journal
2020 Jul Chin J Nat Med
Semisynthesis and in Vitro Anti-cancer Effect of New Magnolol Derivatives on the Cell Proliferation, Apoptosis, Migration, and Invasion of Human Hepatocellular
Journal
Chemical & pharmaceutical bulletin
Hhatl ameliorates endoplasmic reticulum stress through autophagy by associating with LC3
Journal
The Journal of biological chemistry
HRD1-induced TMEM2 ubiquitination promotes ER stress-mediated apoptosis through a non-canonical pathway in intestinal ischemia/reperfusion - PMC
Journal
Cell death & disease