B cell Sirt1 deacetylates histone and non-histone proteins for epigenetic modulation of AID expression and the antibody response
SIRT1 activation synergizes with FXR agonism in hepatoprotection via governing nucleocytoplasmic shuttling and degradation of FXR
Journal
Acta pharmaceutica Sinica. B
CERKL regulates autophagy via the NAD-dependent deacetylase SIRT1
Melatonin/PGC1A/UCP1 promotes tumor slimming and represses tumor progression by initiating autophagy and lipid browning.
Journal
Journal of Pineal Research
Species
Homo sapiens, Mus musculus
Overexpression of PDE4D in mouse liver is sufficient to trigger NAFLD and hypertension in a CD36-TGF-β1 pathway: therapeutic role of roflumilast
Journal
Pharmacological research
Gouqi-derived nanovesicles (GqDNVs) inhibited dexamethasone-induced muscle atrophy associating with AMPK/SIRT1/PGC1 signaling pathway - PMC
Journal
Journal of nanobiotechnology
NCAPD2 inhibits autophagy by regulating Ca2+/CAMKK2/AMPK/mTORC1 pathway and PARP-1/SIRT1 axis to promote colorectal cancer
Declined flesh quality resulting from niacin deficiency is associated with elevated glycolysis and impaired mitochondrial homeostasis in grass carp
Species
Ctenopharyngodon idellus
Resveratrol protects the integrity of alveolar epithelial barrier via SIRT1/PTEN/p-Akt pathway in methamphetamine-induced chronic lung injury
Journal
Cell Proliferation
Metabolic rescue ameliorates mitochondrial encephalo-cardiomyopathy in murine and human iPSC models of Leigh syndrome - PMC
Journal
Clinical and translational medicine
Species
Homo sapiens, Mus musculus
Arctium lappa leaves based on network pharmacology and experimental validation attenuate atherosclerosis by targeting the AMPK-mediated PPARG/LXR
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Application
WB, IHC, IF, ELISA
Dapagliflozin attenuates pressure overload-induced myocardial remodeling in mice via activating SIRT1 and inhibiting endoplasmic reticulum stress
Journal
Acta Pharmacol Sin
SIRT1/FOXO3-mediated autophagy signaling involved in manganese-induced neuroinflammation in microglia
Journal
Ecotoxicology and environmental safety
Resveratrol attenuated oxidative stress and inflammatory and mitochondrial dysfunction induced by acute ammonia exposure in gibel carp (Carassius gibelio)
Journal
Ecotoxicology and environmental safety
Loganin inhibits macrophage M1 polarization and modulates sirt1/NF-B signaling pathway to attenuate ulcerative colitis
Catalpol ameliorates psoriasis-like phenotypes via SIRT1 mediated suppression of NF-κB and MAPKs signaling pathways
Melatonin ameliorates retinal ganglion cell senescence and apoptosis in a SIRT1-dependent manner in an optic nerve injury model
Journal
Biochimica et biophysica acta. Molecular basis of disease
Cigarette Smoke Exposure Increases Glucose-6-phosphate Dehydrogenase, Autophagy, Fibrosis, and Senescence in Kidney Cells In Vitro and In Vivo
Journal
Oxidative medicine and cellular longevity
Lycopene attenuates di(2-ethylhexyl) phthalate-induced mitophagy in spleen by regulating the sirtuin3-mediated pathway
Endothelial Mitochondria Transfer to Melanoma Induces M2-Type Macrophage Polarization and Promotes Tumor Growth by the Nrf2/HO-1-Mediated Pathway - PMC
Journal
International journal of molecular sciences
Orientin Promotes Antioxidant Capacity, Mitochondrial Biogenesis, and Fiber Transformation in Skeletal Muscles through the AMPK Pathway
Journal
Journal of agricultural and food chemistry
Studying Antifatigue Mechanism of Tyr-Pro-Leu-Pro in Exercise Mice Using Label-Free Proteomics
Journal
Journal of agricultural and food chemistry
Species
Mus musculus,Other
Trimetazidine Inhibits Renal Tubular Epithelial Cells to Mesenchymal Transition in Diabetic Rats via Upregulation of Sirt1
Bilobalide Exerts Anti-Inflammatory Effects on Chondrocytes Through the AMPK/SIRT1/mTOR Pathway to Attenuate ACLT-Induced Post-Traumatic Osteoarthritis in Rats
Journal
Frontiers in pharmacology
Polysaccharides From Pogostemon cablin (Blanco) Benth.: Characterization and Antioxidant Activities - PMC
Journal
Frontiers in pharmacology
Hydrogen sulfide attenuates mitochondrial dysfunction-induced cellular senescence and apoptosis in alveolar epithelial cells by upregulating sirtuin 1.
Effect of Yeast-Derived Peptides on Skeletal Muscle Function and Exercise-Induced Fatigue in C2C12 Myotube Cells and ICR Mice
Journal
Journal of agricultural and food chemistry
CYP2E1-dependent upregulation of SIRT7 is response to alcohol mediated metastasis in hepatocellular carcinoma
Journal
Cancer gene therapy
A Deacetylase CqSIRT1 Promotes WSSV Infection by Binding to Viral Envelope Proteins in Cherax quadricarinatus - PMC
Species
Cherax quadricarinatus
EGCG alleviates heat-stress-induced fat deposition by targeting HSP70 through activation of AMPK-SIRT1-PGC-1 in porcine subcutaneous preadipocytes
Journal
Biochemical pharmacology
Quercetin Modulates Ferroptosis via the SIRT1/Nrf-2/HO-1 Pathway and Attenuates Cartilage Destruction in an Osteoarthritis Rat Model - PMC
Journal
International journal of molecular sciences
Quercetin ameliorates oxidative stress-induced senescence in rat nucleus pulposus-derived mesenchymal stem cells via the miR-34a-5p/SIRT1 axis - PMC
Journal
World journal of stem cells
Gold Nanoparticles Encapsulated Resveratrol as an Anti-Aging Agent to Delay Cataract Development - PMC
Journal
Pharmaceuticals (Basel, Switzerland)
p53 deficiency mediates cisplatin resistance by upregulating RRM2 and crotonylation of RRM2K283 through the downregulation of SIRT7 - PMC
Journal
Frontiers in molecular biosciences
Neuroprotection of SRT2104 in Murine Ischemia/Reperfusion Injury Through the Enhancement of Sirt1-Mediated Deacetylation - PMC
Journal
Investigative ophthalmology & visual science
Securidaca inappendiculata-Derived Xanthones Protected Joints from Degradation in Male Rats with Collagen-Induced Arthritis by Regulating PPAR- Signaling
Atractylenolide III Improves Mitochondrial Function and Protects Against Ulcerative Colitis by Activating AMPK/SIRT1/PGC-1
Journal
Mediators of inflammation
A high-concentrate diet induces mitochondrial dysfunction by activating the MAPK signaling pathway in the mammary gland of dairy cows
Journal
Journal of dairy science
Inhibition of 14-3-3 by K50 acetylation activates YAP1 to promote cholangiocarcinoma growth
Journal
Experimental cell research
Effects of manganese on microglia M1/M2 polarization and SIRT1-mediated transcription of STAT3-dependent genes in mouse
Sodium Tanshinone IIA Sulfonate Attenuates Cigarette Smoke Extract-Induced Mitochondrial Dysfunction, Oxidative Stress, and Apoptosis in Alveolar Epithelial Cells by Enhancing SIRT1 Pathway
Journal
Toxicological sciences : an official journal of the Society of Toxicology
Bazi Bushen capsule attenuates cardiac systolic injury via SIRT3/SOD2 pathway in high-fat diet-fed ovariectomized mice - PMC
Single cell RNA-sequencing reveals the cellular senescence of placental mesenchymal stem/stromal cell in preeclampsia
Liquiritin alleviates alpha‐naphthylisothiocyanate‐induced intrahepatic cholestasis through the Sirt1/FXR/Nrf2 pathway
Journal
Journal of applied toxicology : JAT
Histidine ameliorates elastase-and lipopolysaccharide-induced lung inflammation by inhibiting the activation of the NLRP3 inflammasome
Journal
Acta Biochim Biophys Sin (Shanghai)
Astragalus polysaccharide mitigates transport stress-induced hepatic metabolic stress via improving hepatic glucolipid metabolism in chicks
Journal
Journal of animal science
Gentiopicroside ameliorates ovalbumin-induced airway inflammation in a mouse model of allergic asthma via regulating SIRT1/NF-κB signaling pathway
Journal
Pulm Pharmacol Ther
Icariin alleviates the apoptosis of chondrocytes in osteoarthritis through regulating SIRT1Nrf2HO1 signaling
Journal
Chemical biology & drug design
Species
Homo sapiens,Mus musculus
Astragalus polysaccharides attenuate rat aortic endothelial senescence via regulation of the SIRT-1/p53 signaling pathway - PMC
Journal
BMC complementary medicine and therapies
miR-34a regulates adipogenesis in porcine intramuscular adipocytes by targeting ACSL4
Arisaema heterophyllum Blume Monomer Stigmasterol Targets PPARγ and Inhibits the Viability and Tumorigenicity of Lung Adenocarcinoma Cells NCI-H1975 - PMC
Journal
Evidence-based complementary and alternative medicine : eCAM
Kidney-targeted baicalin-lysozyme conjugate ameliorates renal fibrosis in rats with diabetic nephropathy induced by streptozotocin