Genome-wide CRISPR activation screening in senescent cells reveals SOX5 as a driver and therapeutic target of rejuvenation
Reprogramming of Mitochondrial Respiratory Chain Complex by Targeting SIRT3COX4I2 Axis Attenuates Osteoarthritis Progression
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Extracellular Matrix Remodeling Alleviates Memory Deficits in Alzheimer's Disease by Enhancing the Astrocytic AutophagyLysosome Pathway
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Thiram-induced hyperglycemia causes tibial dyschondroplasia by triggering aberrant ECM remodeling via the gut-pancreas axis in broiler chickens
Journal
Journal of hazardous materials
Targeted knockdown of PGAM5 in synovial macrophages efficiently alleviates osteoarthritis - PMC
Retuning Mitochondrial Apoptosis/Mitophagy Balance via SIRT3energized And MicroenvironmentModulated Hydrogel Microspheres to Impede Osteoarthritis
Journal
Advanced healthcare materials
Gold nanoparticles exhibit anti-osteoarthritic effects via modulating interaction of the “microbiota-gut-joint” axis - PMC
Journal
Journal of nanobiotechnology
Pentraxin 3 regulated by miR-224-5p modulates macrophage reprogramming and exacerbates osteoarthritis associated synovitis by targeting CD32 - PMC
Journal
Cell death & disease
The umbilical cord mesenchymal stem cell‐derived exosomal lncRNA H19 improves osteochondral activity through miR‐29b‐3p/FoxO3 axis
Glucagon-like peptide-1 receptor activation maintains extracellular matrix integrity by inhibiting the activity of mitogen-activated protein kinases and activator protein-1
Journal
Free Radic Biol Med
Fucoidan-functionalized gelatin methacryloyl microspheres ameliorate intervertebral disc degeneration by restoring redox and matrix homeostasis of nucleus
Journal
International journal of biological macromolecules
Low-intensity pulsed ultrasound delays the progression of osteoarthritis by regulating the YAP-RIPK1-NF-B axis via influencing autophagy
Journal
Journal of translational medicine
Apigenin Alleviates Intervertebral Disc Degeneration via Restoring Autophagy Flux in Nucleus Pulposus Cells
Journal
Frontiers in cell and developmental biology
The Attenuating Effect of Low-Intensity Pulsed Ultrasound on Hypoxia-Induced Rat Chondrocyte Damage in TMJ Osteoarthritis Based on TMT Labeling Quantitative Proteomic Analysis
Journal
Frontiers in pharmacology
TSP-1 increases autophagy level in cartilage by upregulating HSP27 which delays progression of osteoarthritis
Journal
International immunopharmacology
Inhibition of CC chemokine receptor 1 ameliorates osteoarthritis in mouse by activating PPAR- - PMC
Journal
Molecular medicine (Cambridge, Mass.)
Rspo2 exacerbates rheumatoid arthritis by targeting aggressive phenotype of fibroblast-like synoviocytes and disrupting chondrocyte homeostasis via Wnt/-catenin pathway - PMC
Journal
Arthritis research & therapy
Circ0007042 alleviates intervertebral disc degeneration by adsorbing miR-369 to upregulate BMP2 and activate the PI3K/AKt pathway - PMC
Journal
Arthritis research & therapy
MiR146a modulates chondrogenesis of bone marrow mesenchymal stem cells by modulating Lsm11 expression
Journal
American journal of physiology. Cell physiology
Kartogenin-enhanced dynamic hydrogel ameliorates intervertebral disc degeneration via restoration of local redox homeostasis - PMC
Journal
Journal of orthopaedic translation
Curcumin reverses erastin-induced chondrocyte ferroptosis by upregulating Nrf2 - PMC
Pentraxin 3 deficiency ameliorates the severity of osteoarthritis and alleviates inflammation
Journal
Biochemical and biophysical research communications