Icariside Ⅱ, a main compound in Epimedii Folium, induces idiosyncratic hepatotoxicity by enhancing NLRP3 inflammasome activation
Cadmium exposure induces pyroptosis in testicular tissue by increasing oxidative stress and activating the AIM2 inflammasome pathway
Journal
The Science of the total environment
Zinc oxide nanoparticles exacerbate skin epithelial cell damage by upregulating pro-inflammatory cytokines and exosome secretion in M1 macrophages following UVB irradiation-induced skin injury - PMC
Journal
Particle and fibre toxicology
Inhibition of heat shock protein family A member 8 attenuates spinal cord ischemia-reperfusion injury via astrocyte NF-B/NLRP3 inflammasome pathway : HSPA8 inhibition protects spinal ischemia-reperfusion injury
Journal
J Neuroinflammation
Isoliquiritigenin alleviates early brain injury after experimental intracerebral hemorrhage via suppressing ROS- and/or NF-κB-mediated NLRP3 inflammasome activation by promoting Nrf2 antioxidant pathway.
Journal
Journal of Neuroinflammation
Repurposing nitazoxanide as a novel anti‐atherosclerotic drug based on mitochondrial uncoupling mechanisms
Journal
British journal of pharmacology
Benzo[a]pyrene induces NLRP1 expression and promotes prolonged inflammasome signaling - PMC
Journal
Frontiers in immunology
Benzo[a]pyrene induces NLRP1 expression and promotes prolonged inflammasome signaling - PMC
Journal
Frontiers in immunology
miR-29b-3p regulates cardiomyocytes pyroptosis in CVB3-induced myocarditis through targeting DNMT3A - PMC
Journal
Cellular & molecular biology letters
Filarial thioredoxin reductase exerts anti-inflammatory effects upon lipopolysaccharide induced inflammation in macrophages
Journal
Int J Biol Macromol
The hepatoprotective effect of myricetin against lipopolysaccharide and D-galactosamine-induced fulminant hepatitis
Journal
International Journal of Biological Macromolecules
Polygala tenuifolia Willd. extract alleviates LPS-induced acute lung injury in rats via TLR4/NF-B pathway and NLRP3 inflammasome suppression
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Targeting antioxidant factor Nrf2 by raffinose ameliorates lipid dysmetabolism-induced pyroptosis, inflammation and fibrosis in NAFLD
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Shen-Shuai-II-Recipe inhibits tubular inflammation by PPAR-mediated fatty acid oxidation to attenuate fibroblast activation in fibrotic kidneys
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Baohuoside I suppresses the NLRP3 inflammasome activation via targeting GPER to fight against Parkinson's disease
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Biochanin A Ameliorates Nephropathy in High-Fat Diet/Streptozotocin-Induced Diabetic Rats: Effects on NF-kB/NLRP3 Axis, Pyroptosis, and Fibrosis - PMC
Journal
Antioxidants (Basel, Switzerland)
AIP1 suppresses neovascularization by inhibiting the NOX4-induced NLRP3/NLRP6 imbalance in a murine corneal alkali burn model
Journal
Cell communication and signaling : CCS
Tricyclic antidepressants induce liver inflammation by targeting NLRP3 inflammasome activation - PMC
Journal
Cell communication and signaling : CCS
MCC950 attenuates doxorubicin-induced myocardial injury in vivo and in vitro by inhibiting NLRP3-mediated pyroptosis
Journal
Biomed Pharmacother
Melatonin alleviates doxorubicin-induced cardiotoxicity via inhibiting oxidative stress, pyroptosis and apoptosis by activating Sirt1/Nrf2 pathway
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Protective effects of Eleutheroside E against high-altitude pulmonary edema by inhibiting NLRP3 inflammasome-mediated pyroptosis
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Disrupted mitochondrial transcription factor A expression promotes mitochondrial dysfunction and enhances ocular surface inflammation by activating the absent in
Journal
Free radical biology & medicine
Polysaccharides from Garlic Protect against Liver Injury in DSS-Induced Inflammatory Bowel Disease of Mice via Suppressing Pyroptosis and Oxidative Damage - PMC
Journal
Oxidative medicine and cellular longevity
Disulfiram attenuates hypoxia-induced pulmonary hypertension by inhibiting GSDMD cleavage and pyroptosis in HPASMCs - PMC
Journal
Respiratory research
Protective effect and mechanism of baicalin on lung inflammatory injury in BALB/cJ mice induced by PM2. 5
Journal
Ecotoxicology and environmental safety
Cadmium exposure induces pyroptosis of TM4 cells through oxidative stress damage and inflammasome activation
Journal
Ecotoxicology and environmental safety
Bacillus cereus cereolysin O induces pyroptosis in an undecapeptide-dependent manner - PMC
Journal
Cell death discovery
MiR-1224-5p attenuates polycystic ovary syndrome through inhibiting NOD-like receptor protein 3 inflammasome activation via targeting Forkhead box O 1
Mitophagy protects against silver nanoparticleinduced hepatotoxicity by inhibiting mitochondrial ROS and the NLRP3 inflammasome
Journal
Ecotoxicology and environmental safety
Inhibition of SGLT1 protects against glycemic variability-induced cardiac damage and pyroptosis of cardiomyocytes in diabetic mice
GYY4137 alleviates sepsis-induced acute lung injury in mice by inhibiting the PDGFRβ/Akt/NF-κB/NLRP3 pathway
Glabridin Ameliorates Alcohol-Caused Liver Damage by Reducing Oxidative Stress and Inflammation via p38 MAPK/Nrf2/NF-B Pathway - PMC
Daucosterol Alleviates Alcohol-Induced Hepatic Injury and Inflammation through P38/NF-κB/NLRP3 Inflammasome Pathway - PMC
Ginsenoside Rb1 ameliorates cardiotoxicity triggered by aconitine via inhibiting calcium overload and pyroptosis
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Egg Yolk Lipids Alleviated Dextran Sulfate SodiumInduced Colitis by Inhibiting NLRP3 Inflammasome and Regulating Gut Microbiota
Journal
Molecular nutrition & food research
Human Parvovirus Infection of Human Airway Epithelia Induces Pyroptotic Cell Death by Inhibiting Apoptosis
Journal
Journal of Virology
Low shear stress regulates vascular endothelial cell pyroptosis through miR‐181b‐5p/STAT‐3 axis
Journal
Journal of cellular physiology
Dichotomous Roles of Men1 in Macrophages and Fibroblasts in Bleomycin-Induced Pulmonary Fibrosis
Journal
International journal of molecular sciences
Highly Effective NobiletinMPN in Yeast Microcapsules for Targeted Modulation of Oxidative Stress, NLRP3 Inflammasome Activation, and Immune Responses in
Journal
Journal of agricultural and food chemistry
The Ameliorative Role of Lico A on Aflatoxin B1-Triggered Hepatotoxicity Partially by Activating Nrf2 Signal Pathway
Journal
Journal of agricultural and food chemistry
GLUT1 promotes NLRP3 inflammasome activation of airway epithelium in lipopolysaccharide-induced acute lung injury
Journal
The American journal of pathology
-Caryophyllene Ameliorates MSU-Induced Gouty Arthritis and Inflammation Through Inhibiting NLRP3 and NF-B Signal Pathway: In Silico and In Vivo
Hydroxysafflor Yellow A Protects Against Myocardial Ischemia/Reperfusion Injury via Suppressing NLRP3 Inflammasome and Activating Autophagy
CVB3 Inhibits NLRP3 Inflammasome Activation by Suppressing NF-κB Pathway and ROS Production in LPS-Induced Macrophages - PMC
Fraxin ameliorates lipopolysaccharide-induced acute lung injury in mice by inhibiting the NF-B and NLRP3 signalling pathways.
Journal
International immunopharmacology
Carnosine alleviates podocyte injury in diabetic nephropathy by targeting caspase-1-mediated pyroptosis
Journal
Int Immunopharmacol
Anti-inflammatory effect of Yam Glycoprotein on lipopolysaccharide-induced acute lung injury via the NLRP3 and NF-κB/TLR4 signaling pathway
Journal
International Immunopharmacology
GKLF, a transcriptional activator of Txnip, drives microglia activation in kainic acid-induced murine models of epileptic seizures
Journal
International immunopharmacology
Sodium tanshinone IIA sulfonate attenuates sepsis-associated brain injury via inhibiting NOD-like receptor 3/caspase-1/gasdermin D-mediated pyroptosis
Journal
International immunopharmacology
Eleutheroside E from pre-treatment of Acanthopanax senticosus (Rupr. etMaxim.) Harms ameliorates high-altitude-induced heart injury by regulating NLRP3
Journal
International immunopharmacology
Thymopentin (TP-5) prevents lipopolysaccharide-induced neuroinflammation and dopaminergic neuron injury by inhibiting the NF-κB/NLRP3 signaling pathway
Journal
International immunopharmacology
β-Hydroxybutyrate alleviates pyroptosis in MPP+/MPTP-induced Parkinson's disease models via inhibiting STAT3/NLRP3/GSDMD pathway
Journal
International immunopharmacology
Psoralidin, a major component of psoraleae fructus, induces inflammasome activation and idiosyncratic liver injury
Journal
International immunopharmacology
Isobavachalcone's Alleviation of Pyroptosis Contributes to Enhanced Apoptosis in Glioblastoma: Possible Involvement of NLRP3
Journal
Molecular neurobiology
Dapagliflozin prevents kidney podocytes pyroptosis via miR-155-5p/HO-1/NLRP3 axis modulation
Journal
International immunopharmacology
Copper induces microglia-mediated neuroinflammation through ROS/NF-κB pathway and mitophagy disorder
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Inhibition of microglial receptor‐interacting protein kinase 1 ameliorates neuroinflammation following cerebral ischaemic stroke
Glycogen synthase kinase-3 inhibition decreases inflammation and relieves cancer induced bone pain via reducing Drp1-mediated mitochondrial damage - PMC
Journal
Journal of cellular and molecular medicine
Shiwei Qingwen decoction regulates TLR4/NF-B signaling pathway and NLRP3 inflammasome to reduce inflammatory response in lipopolysaccharide-induced
Journal
Journal of ethnopharmacology
Oroxylin a promoted apoptotic extracellular vesicles transfer of glycolytic kinases to remodel immune microenvironment in hepatocellular carcinoma model
Journal
European journal of pharmacology
Paeoniflorin attenuates particulate matter-induced acute lung injury by inhibiting oxidative stress and NLRP3 inflammasome-mediated pyroptosis through activation of
Journal
Chemico-biological interactions
Mesenchymal stem cells overexpressing PBX1 alleviates haemorrhagic shock-induced kidney damage by inhibiting NF-B activation
Journal
Biochimica et biophysica acta. Molecular cell research
Paeoniflorin inhibited nod-like receptor protein-3 inflammasome and NF-κB-mediated inflammatory reactions in diabetic foot ulcer by inhibiting the chemokine receptor CXCR2
Journal
Drug development research
Nrf2 mediates the effects of shionone on silica-induced pulmonary fibrosis - PMC
Total glucosides of paeony alleviates experimental Sjgren's syndrome through inhibiting NLRP3 inflammasome activation of submandibular gland cells
Journal
Clinical and experimental rheumatology
STING deletion alleviates podocyte injury through suppressing inflammation by targeting NLRP3 in diabetic kidney disease
Journal
Cellular signalling
Overexpression of TOLLIP Protects against Acute Kidney Injury after Paraquat Intoxication through Inhibiting NLRP3 Inflammasome Activation Modulated by Toll-Like Receptor 2/4 Signaling
The Critical Role of Pyroptosis in Peri-Implantitis
Journal
Journal of inflammation research
A Novel Mechanism of Specialized Proresolving Lipid Mediators Mitigating Radicular Pain: The Negative Interaction With NLRP3 Inflammasome
Journal
Neurochemical research
Unmasking the dynamics of Mycoplasma gallisepticum: deciphering HD11 macrophage polarization for innovative infection control strategies
P2X7 Receptor-Induced Bone Cancer Pain by Regulating Microglial Activity via NLRP3/IL-1beta Signaling
Maresin-2 alleviates allergic airway inflammation in mice by inhibiting the activation of NLRP3 inflammasome, Th2 type immune response and oxidative stress
Journal
Molecular immunology
MiR-4953p attenuates cell pyroptosis and endometritis through inhibiting the activation of NLRP3 inflammasome in bovine
Journal
Molecular immunology
S1P/S1PR1 axis promotes macrophage M1 polarization through NLRP3 inflammasome activation in Lupus nephritis
Journal
Molecular immunology
ALK-JNK signaling promotes NLRP3 inflammasome activation and pyroptosis via NEK7 during Streptococcus pneumoniae infection
Journal
Molecular immunology
Species
Streptococcus pneumoniae
Involvement of estrogen receptor activation in kaempferol-3-O-glucoside's protection against aging-related cognition impairment and microglial inflammation
Journal
Experimental cell research
Modified Danzhi XiaoyaoSan inhibits neuroinflammation via regulating TRIM31/NLRP3 inflammasome in the treatment of CUMS depression
Journal
Experimental gerontology
Intermittent high glucose induces pyroptosis of rat H9C2 cardiomyocytes via sodium-glucose cotransporter 1
Gambogic acid ameliorates high glucose–and palmitic acid–induced inflammatory response in ARPE-19 cells via activating Nrf2 signaling pathway: ex vivo
Journal
Cell Stress Chaperones
CLEC5A knockdown protects against the cardiac dysfunction after Myocardial infarction by suppressing macrophage polarization, NLRP3 inflammasome activation and pyroptosis
PHLDA1 Blockade Alleviates Cerebral Ischemia/Reperfusion Injury by Affecting Microglial M1/M2 Polarization and NLRP3 Inflammasome Activation
Hydrogen Attenuates Myocardial Injury in Rats by Regulating Oxidative Stress and NLRP3 Inflammasome Mediated Pyroptosis
Effects of PYRIN-containing Apaf1-like protein 1 on isoflurane-induced postoperative cognitive dysfunction in aged rats
Celastrol attenuates human parvovirus B19 NS1-induced NLRP3 inflammasome activation in macrophages - PMC
Journal
Molecular medicine reports
Melatonin attenuates high glucose-induced endothelial cell pyroptosis by activating the Nrf2 pathway to inhibit NLRP3 inflammasome activation - PMC
Journal
Molecular medicine reports
Melatonin alleviates cigarette smoke-induced endothelial cell pyroptosis through inhibiting ROS/NLRP3 axis
Journal
Biochemical and biophysical research communications
CD147 Aggravated Inflammatory Bowel Disease by Triggering NF-κB-Mediated Pyroptosis
Quercetin effectively improves LPS-induced intestinal inflammation, pyroptosis, and disruption of the barrier function through the TLR4/NF-B/NLRP3 signaling pathway in vivo and in vitro - PMC
Journal
Food & nutrition research
HBx-induced PLA2R overexpression mediates podocyte pyroptosis through the ROS-NLRP3 signaling pathway - PMC
Preventive effect of dioscin against monosodium urate-mediated gouty arthritis through inhibiting inflammasome NLRP3 and TLR4/NF-κB signaling pathway activation: an in vivo and in vitro study
Bakuchiol ameliorates cerebral ischemia-reperfusion injury by modulating NLRP3 inflammasome and Nrf2 signaling
Journal
Respir Physiol Neurobiol
Fraxin inhibits lipopolysaccharide-induced inflammatory cytokines and protects against endotoxic shock in mice.
Journal
Fundamental & clinical pharmacology
Prevention of Bleomycin-Induced Pulmonary Inflammation and Fibrosis in Mice by Bilobalide - PMC
Journal
Evidence-based complementary and alternative medicine : eCAM
The anti-periodontitis action of metformin via targeting NLRP3 inflammasome
Journal
Archives of Oral Biology
Cytosolic dsDNA is a novel senescence marker associated with pyroptosis activation
Overexpression of miR-224-5p alleviates allergic rhinitis in mice via the TLR4/MyD88/NF-κB pathway
Rubus chingii Hu relieved the polycystic ovary syndrome with enhanced insulin sensitivity through inhibiting TXNIP/NLRP3 inflammasome signaling
Journal
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
Paeonol Pretreatment Attenuates Anoxia-Reoxygenation Induced Injury in Cardiac Myocytes via a BRCA1 Dependent Pathway
Journal
Chem Pharm Bull (Tokyo)
HDAC6 inhibition alleviates acute pulmonary embolism: a possible future therapeutic option
Journal
Folia histochemica et cytobiologica
Low-dose arsenite causes overexpression of EGF, TGFα, and HSP90 through Trx1-TXNIP-NLRP3 axis mediated signaling pathways in the human bladder …
Journal
Ecotoxicol Environ Saf
Differential inflammatory responses of the native left and right ventricle associated with donor heart preservation