Regulation of an osteon-like concentric microgrooved surface on osteogenesis and osteoclastogenesis.
Reactive oxygen species trigger NF-B-mediated NLRP3 inflammasome activation involvement in low-dose CdTe QDs exposure-induced hepatotoxicity
Value added immunoregulatory polysaccharides of Hericium erinaceus and their effect on the gut microbiota
Flavonoid-rich sesame leaf extract-mediated synthesis of nanozymes: Extraction optimization, chemical composition identification and bioactivity evaluation
Microarray Analysis Identifies the Potential Role of Long Non-Coding RNA in Regulating Neuroinflammation during Japanese Encephalitis Virus Infection
Journal
Frontiers in immunology
CRM197-conjugated multi antigen dominant epitope for effective human cytomegalovirus vaccine development
Journal
International journal of biological macromolecules
Species
Homo sapiens, Mus musculus
Soluble Epoxide Hydrolase Inhibitor t-AUCB Ameliorates Vascular Endothelial Dysfunction by Influencing the NF-κB/miR-155-5p/eNOS/NO/IκB Cycle in Hypertensive Rats - PMC
Journal
Antioxidants (Basel, Switzerland)
BAFF Blockade Attenuates Inflammatory Responses and Intestinal Barrier Dysfunction in a Murine Endotoxemia Model
Journal
Frontiers in Immunology
Minocycline attenuates bone cancer pain in rats by inhibiting NF-κB in spinal astrocytes
Journal
Acta Pharmacologica Sinica
Morinda officinalis oligosaccharides alleviate depressive-like behaviors in post-stroke rats via suppressing NLRP3 inflammasome to inhibit hippocampal inflammation
CTSV (cathepsin V) promotes bladder cancer progression by increasing NF-κB activity
PIGU promotes hepatocellular carcinoma progression through activating NF-κB pathway and increasing immune escape
Polysaccharides from Hericium erinaceus Fruiting Bodies: Structural Characterization, Immunomodulatory Activity and Mechanism - PMC
Species
Homo sapiens, Mus musculus
Effects and Mechanisms of Rhus chinensis Mill. Fruits on Suppressing RANKL-Induced Osteoclastogenesis by Network Pharmacology and Validation in RAW264.7 Cells
Schisantherin A ameliorates liver fibrosis through TGF-β1mediated activation of TAK1/MAPK and NF-κB pathways in vitro and in vivo
Chemical constituents and anti-inflammatory activity of the total alkaloid extract from Melodinus cochinchinensis (Lour.) Merr. and its inhibition of the NF-κB and MAPK signaling pathways
Species
Melodinus cochinchinensis
Japanese Encephalitis Virus NS5 Inhibits Type I Interferon (IFN) Production by Blocking the Nuclear Translocation of IFN Regulatory Factor 3 and NF-κB
Journal
Journal of Virology
GPA Peptide-Induced Nur77 Localization at Mitochondria Inhibits Inflammation and Oxidative Stress through Activating Autophagy in the Intestine
Journal
Oxid Med Cell Longev
Pimpinellin ameliorates macrophage inflammation by promoting RNF146mediated PARP1 ubiquitination
Journal
Phytotherapy research : PTR
Delivery of mesenchymal stem cells-derived extracellular vesicles with enriched miR-185 inhibits progression of OPMD
Journal
Artificial cells, nanomedicine, and biotechnology
Preparation, characterization, and in vivo evaluation of anti-inflammatory activities of selenium nanoparticles synthesized by Kluyveromyces lactis GG799
Investigation of the active components and mechanisms of Schisandra chinensis in the treatment of asthma based on a network pharmacology approach and experimental validation
Species
Rattus norvegicus,Schisandra chinensis
The preventive effect and underlying mechanism of Rhus chinensis Mill. fruits on dextran sulphate sodium-induced ulcerative colitis in mice
The mechanism of ginger and its processed products in the treatment of estradiol valerate coupled with oxytocin-induced dysmenorrhea in mice via regulating …
Gastroprotective effect and mechanisms of Chinese sumac fruits (Rhus chinensis Mill.) on ethanol-induced gastric ulcers in mice
Apigenin protects mice against 3, 5-diethoxycarbonyl-1, 4-dihydrocollidine-induced cholestasis
Aloe-Emodin Ameliorates Cecal Ligation and Puncture-Induced Sepsis
Journal
International journal of molecular sciences
Application
ELISA, WB, IHC
SHIP1 Activator AQX-1125 Regulates Osteogenesis and Osteoclastogenesis Through PI3K/Akt and NF-κb Signaling
Journal
Frontiers in cell and developmental biology
Mechanism of Apoptosis Induction by Mycoplasmal Nuclease MGA_0676 in Chicken Embryo Fibroblasts
Journal
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
p21-Activated Kinase 4 Signaling Promotes Japanese Encephalitis Virus-Mediated Inflammation in Astrocytes
Journal
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
GPA peptide enhances Nur77 expression in intestinal epithelial cells to exert a 1 protective effect against DSS-induced colitis
Myricanol attenuates sepsis-induced inflammatory responses by nuclear factor erythroid 2-related factor 2 signaling and nuclear factor kappa B/mitogen-activated
Journal
Inflammopharmacology
Exposure to PM2.5 induces aberrant activation of NF-κB in human airway epithelial cells by downregulating miR-331 expression
Journal
Environmental Toxicology and Pharmacology
Loganin alleviates sepsis-induced acute lung injury by regulating macrophage polarization and inhibiting NLRP3 inflammasome activation
6-Gingerol attenuates ventilator-induced lung injury via anti-inflammation and antioxidative stress by modulating the PPARγ/NF-κB signalling pathway in rats
Journal
International immunopharmacology
NecroX-5 alleviate lipopolysaccharide-induced acute respiratory distress syndrome by inhibiting TXNIP/NLRP3 and NF-κB
Journal
International Immunopharmacology
Anti-inflammatory effect of Yam Glycoprotein on lipopolysaccharide-induced acute lung injury via the NLRP3 and NF-κB/TLR4 signaling pathway
Journal
International Immunopharmacology
Perillaldehyde: A promising antibacterial agent for the treatment of pneumonia caused by Acinetobacter baumannii infection
Journal
International immunopharmacology
Avian safety guardian: Luteolin restores Mycoplasma gallisepticum-induced immunocompromise to improve production performance via inhibiting the IL-17/NF-kB
Journal
International immunopharmacology
Deletion of Insulin-like growth factor II mRNA-binding protein 3 participates in the pathogenesis of recurrent spontaneous abortion by inhibiting IL-10 secretion and …
Journal
International immunopharmacology
MEF2 intervened LPS-induced acute lung injury by binding to KLF2 promoter and modulating macrophage phenotype
Journal
International immunopharmacology
Anti-Neuroinflammatory Effect of Ombuin from Rhamnus erythroxylon Pall. Leaves in LPS-Induced BV-2 Microglia by Targeting Src and Suppressing the PI3K-AKT/NF-B Signaling Pathway - PMC
Journal
International journal of molecular sciences
Copper induces microglia-mediated neuroinflammation through ROS/NF-κB pathway and mitophagy disorder
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Diverse Galactooligosaccharides Differentially Reduce LPS-Induced Inflammation in Macrophages - PMC
Journal
Foods (Basel, Switzerland)
Piper longum L. ameliorates gout through the MAPK/PI3K-AKT pathway
Journal
Journal of ethnopharmacology
ISG12a and its interaction partner NR4A1 are involved in TRAIL-induced apoptosis in hepatoma cells.
Journal
Journal of Cellular and Molecular Medicine
Chinese sumac (Rhus chinensis Mill.) fruits alleviate indomethacin-induced gastric ulcer in mice by improving oxidative stress, inflammation and apoptosis
Anneslea fragrans Wall. ameliorates ulcerative colitis via inhibiting NF-κB and MAPK activation and mediating intestinal barrier integrity
Optimization of ultrasound extraction of Tribulus terrestris L. leaves saponins and their HPLC-DAD-ESI-MSn profiling, anti-inflammatory activity and mechanism in vitro and in vivo
In vitro and in vivo anti-inflammatory effects of different extracts from Epigynum auritum through down-regulation of NF-κB and MAPK signaling pathways
Isorhynchophylline ameliorates the progression of osteoarthritis by inhibiting the NF-B pathway
Journal
European journal of pharmacology
Potential Anti-Gout Properties of Wuwei Shexiang Pills Based on Network Pharmacology and Pharmacological Verification
Journal
Journal of ethnopharmacology
Strictosamide alleviates the inflammation in an acute ulcerative colitis (UC) model
Protective Effects of Selenium Nanoparticle-Enriched Lactococcus lactis NZ9000 against Enterotoxigenic Escherichia coli K88-Induced Intestinal Barrier Damage in Mice
Journal
Applied and environmental microbiology
Keratin 8 limits TLR-triggered inflammatory responses through inhibiting TRAF6 polyubiquitination
Journal
Scientific Reports
AQP4 Attenuated TRAF6/NFκB Activation in Acrylamide-Induced Neurotoxicity
Journal
Molecules (Basel, Switzerland)
Inhibition of miRNA-1-Mediated Inflammation and Autophagy by Astragaloside IV Improves Lipopolysaccharide-Induced Cardiac Dysfunction in Rats
Journal
Journal of inflammation research
Preparation and Evaluation of Folate Modified PEG-PLLA Nanoparticles Loaded with Lycorine for Glioma Treatment - PMC
Journal
Molecules (Basel, Switzerland)
Fraxetin inhibits interleukin-1β-induced apoptosis, inflammation, and matrix degradation in chondrocytes and protects rat cartilage in vivo
I 4, a synthetic anti-diabetes agent, attenuates atherosclerosis through its lipid-lowering, anti-inflammatory and anti-apoptosis properties
Journal
Molecular And Cellular Endocrinology
Hydrogen gas inhalation ameliorates LPS-induced BPD by inhibiting inflammation via regulating the TLR4-NFB-IL6/NLRP3 signaling pathway in the placenta - PMC
Journal
European journal of medical research
HMGB1-TLR4 signaling participates in renal ischemia reperfusion injury and could be attenuated by dexamethasone-mediated inhibition of the ERK/NF-κB pathway.
Journal
American Journal of Translational Research
Preparation, characterization and pharmacodynamic study on deep second degree burns of total flavonoids composite phospholipids liposome of Oxytropis falcata Bunge
Journal
Drug Dev Ind Pharm
Tectoridin alleviates lipopolysaccharide-induced inflammation via inhibiting TLR4-NF-κB/NLRP3 signaling in vivo and in vitro
Journal
Immunopharmacology and immunotoxicology
The anti-inflammatory effect of Andrographis paniculata (Burm. f.) Nees on pelvic inflammatory disease in rats through down-regulation of the NF-B pathway.
Journal
BMC Complementary and Alternative Medicine
Glutamylcysteine alleviates ethanolinduced hepatotoxicity via suppressing oxidative stress, apoptosis, and inflammation
Journal
Journal of food biochemistry
Knockdown of Serum- and Glucocorticoid-Regulated Kinase 1 Enhances Cisplatin Sensitivity of Gastric Cancer Through Suppressing the Nuclear Factor Kappa-B Signaling Pathway
MicroRNA?16?5p/BIMP1/NF?κB axis regulates autophagy to exert a tumor?suppressive effect on bladder cancer
7‑Difluoromethyl‑5,4'‑dimethoxygenistein exerts anti‑angiogenic effects on acute promyelocytic leukemia HL‑60 cells by inhibiting the TLR4/NF‑κB signaling pathway
Journal
Molecular Medicine Reports
Regulator of G-protein signalling 5 deficiency impairs ventricular remodelling after myocardial infarction by promoting NF-κB and MAPK signalling in mice
Journal
biochemical and biophysical research communications
Suffrutines A and B Inhibit the Expression of Inflammatory Mediators in LPS-Induced RAW264. 7 Cells by Suppressing the NF-B Signaling Pathway
Inhibited Expression of NLRP12 Promotes the Development of Triple-Negative Breast Cancer by Activating the NF-B Pathway
Journal
Cell biochemistry and biophysics
Immunoenhancement activity of Bletilla striata polysaccharide through MAPK and NF-κB signalling pathways in vivo and in vitro
Protective Effects of Anwulignan against HCl/Ethanol-Induced Acute Gastric Ulcer in Mice
Journal
Evid Based Complement Alternat Med
miR‐29c‐3p inhibits microglial NLRP3 inflammasome activation by targeting NFAT5 in Parkinson's disease
Journal
Genes to cells : devoted to molecular & cellular mechanisms
Down-regulation of PSMD4 can attenuate autophagy, enhance the accumulation of intracellular ROS, and increase the sensitivity of epithelial ovarian cancer to carboplatin by inhibiting the NF-B pathway
Journal
Translational cancer research