Tumor-induced reshuffling of lipid composition on the endoplasmic reticulum membrane sustains macrophage survival and pro-tumorigenic activity
Disruption of Gpr45 causes reduced hypothalamic POMC expression and obesity
Journal
Journal Of Clinical Investigation
Intrinsic RIG-I restrains STAT5 activation to modulate anti-tumor activity of CD8+ T cells
Journal
The Journal of clinical investigation
HDAC9-mediated epithelial cell cycle arrest in G2/M contributes to kidney fibrosis in male mice - PMC
Journal
Nature communications
Urate-Lowering Therapy Inhibits Thoracic Aortic Aneurysm and Dissection Formation in Mice
Journal
Arteriosclerosis, thrombosis, and vascular biology
Oroxylin A suppresses ACTN1 expression to inactivate cancer-associated fibroblasts and restrain breast cancer metastasis
TOPK promotes the development of psoriasis and worenine alleviates psoriasiform dermatitis by inhibiting TOPK activity
Journal
Journal of the European Academy of Dermatology and Venereology : JEADV
TAGAP expression influences CD4+ T cell differentiation, immune infiltration, and cytotoxicity in LUAD through the STAT pathway: implications for immunotherapy - PMC
Journal
Frontiers in immunology
Chicken cecal microbiota reduces abdominal fat deposition by regulating fat metabolism - PMC
Journal
NPJ biofilms and microbiomes
Targeting macrophagic PIM-1 alleviates osteoarthritis by inhibiting NLRP3 inflammasome activation via suppressing mitochondrial ROS/Cl- efflux signaling pathway - PMC
Journal
Journal of translational medicine
STAT3-mediated ferroptosis is involved in ulcerative colitis
Journal
Free radical biology & medicine
IKBKE, a prognostic factor preferentially expressed in mesenchymal glioblastoma, modulates tumoral immunosuppression through the STAT3/PD‐L1 pathway
Identification of Lipocalin 2 as a Ferroptosis-Related Key Gene Associated with Hypoxic-Ischemic Brain Damage via STAT3/NF-κB Signaling Pathway - PMC
Journal
Antioxidants (Basel, Switzerland)
Lotus Bee Pollen Extract Inhibits Isoproterenol-Induced Hypertrophy via JAK2/STAT3 Signaling Pathway in Rat H9c2 Cells - PMC
Journal
Antioxidants (Basel, Switzerland)
LW-213, a newly synthesized flavonoid, induces G2/M phase arrest and apoptosis in chronic myeloid leukemia.
Journal
Acta Pharmacologica Sinica
Clusterin inhibits Cr (VI)-induced apoptosis via enhancing mitochondrial biogenesis through AKT-associated STAT3 activation in L02 hepatocytes
Journal
Ecotoxicol Environ Saf
Enterovirus D68 infection upregulates SOCS3 expression to inhibit JAK-STAT3 signaling and antagonize the innate interferon response of the host
Induction of cell cycle arrest and apoptosis by CPUC002 through stabilization of p53 and suppression of STAT3 signaling pathway in multiple myeloma
Taurohyodeoxycholic acid alleviates trinitrobenzene sulfonic acid induced ulcerative colitis via regulating Th1/Th2 and Th17/Treg cells balance
Protein Disulfide Isomerase Family A Member 3 Knockout Abrogate Effects of Vitamin D on Cellular Respiration and Glycolysis in Squamous Cell Carcinoma - PMC
Neuroprotective Effects of Ecklonia cava in a Chronic Neuroinflammatory Disease Model
Downregulation of miR-29c promotes muscle wasting by modulating the activity of leukemia inhibitory factor in lung cancer cachexia
Gastric cancer cell-originated small extracellular vesicle induces metabolic reprogramming of BM-MSCs through ERK-PPARγ-CPT1A signaling to potentiate lymphatic metastasis - PMC
Journal
Cancer cell international
OB-RGRP regulates the phosphorylation of JAK2 and STAT3 in primary rat adipocytes
Journal
Artificial cells, nanomedicine, and biotechnology
Polycyclic polyprenylated acylphloroglucinols from Garcinia xanthochymus fruits exhibit antitumor effects by inhibition of STAT3 signaling pathway
Species
Homo sapiens, Mus musculus
Folic acid intervention changes liver Foxp3 methylation and ameliorates the damage caused by Th17/Treg imbalance after long-term alcohol exposure
Diclofenac Sensitizes Signet Ring Cell Gastric Carcinoma Cells to Cisplatin by Activating Autophagy and Inhibition of Survival Signal Pathways - PMC
Journal
International journal of molecular sciences
Changes in the Expression and Functional Activities of C-X-C Motif Chemokine Ligand 13 (CXCL13) in Hyperplastic Prostate - PMC
Journal
International journal of molecular sciences
Species
Homo sapiens,Rattus norvegicus
Integrated Bioinformatic Investigation of EXOSCs in Hepatocellular Carcinoma Followed by the Preliminary Validation of EXOSC5 in Cell Proliferation - PMC
Journal
International journal of molecular sciences
Aucubin protects mouse cochlear hair cells from cisplatin-induced ototoxicity via activation of the PI3K/AKT/STAT3 pathway
Journal
Biochemical pharmacology
Harmine Alleviated Sepsis-Induced Cardiac Dysfunction by Modulating Macrophage Polarization via the STAT/MAPK/NF-κB Pathway.
Journal
Frontiers in cell and developmental biology
ANGPTL4 Regulates Psoriasis via Modulating Hyperproliferation and Inflammation of Keratinocytes - PMC
Journal
Frontiers in pharmacology
Species
Homo sapiens, Mus musculus
MOB1A regulates glucose deprivation-induced autophagy via IL6-STAT3 pathway in gallbladder carcinoma
Cyanidin restores Th17/Treg balance and inhibits T follicular helper cell differentiation via modulation of ROCK2 signaling in an experimental model of rheumatoid arthritis
Journal
Int Immunopharmacol
Piperine ameliorates psoriatic skin inflammation by inhibiting the phosphorylation of STAT3
Journal
International immunopharmacology
Complement C5 activation promotes type 2 diabetic kidney disease via activating STAT3 pathway and disrupting the gutkidney axis
Species
Homo sapiens, Mus musculus
Panlongqi tablet suppresses adjuvant-induced rheumatoid arthritis by inhibiting the inflammatory reponse in vivo and in vitro
Journal
Journal of ethnopharmacology
The alcohol extracts of Sceptridium ternatum (Thunb.) Lyon exert anti-pulmonary fibrosis effect through targeting SETDB1/STAT3/p-STAT3 signaling
Journal
Journal of ethnopharmacology
Quyu Shengxin capsule (QSC) inhibits Ang-II-induced abnormal proliferation of VSMCs by down-regulating TGF-β, VEGF, mTOR and JAK-STAT pathways
Journal
Journal of ethnopharmacology
Kaempferol suppresses glioma progression and synergistically enhances the antitumor activity of gefitinib by inhibiting the EGFR/SRC/STAT3 signaling pathway
Journal
Drug development research
Centipeda minima Extract Inhibits Inflammation and Cell Proliferation by Regulating JAK/STAT Signaling in Macrophages and Keratinocytes - PMC
Journal
Molecules (Basel, Switzerland)
Species
Homo sapiens, Mus musculus
Suppression of autophagy through JAK2/STAT3 contributes to the therapeutic action of rhynchophylline on asthma
Journal
BMC Complement Med Ther
Curcumae radix Reduces Endoplasmic Reticulum Stress in Mice with Chronic Neuroinflammation - PMC
Securidaca inappendiculata-Derived Xanthones Protected Joints from Degradation in Male Rats with Collagen-Induced Arthritis by Regulating PPAR- Signaling
Suan-Zao-Ren Decoction ameliorates synaptic plasticity through inhibition of the Aβ deposition and JAK2/STAT3 signaling pathway in AD model of APP/PS1 transgenic mice.
Paclitaxel combined with Compound K inducing pyroptosis of non-small cell lung cancer cells by regulating Treg/Th17 balance - PMC
PI3K/AKT/mTOR Signaling Pathway Is Downregulated by Runzaoling (RZL) in Sjögren's Syndrome - PMC
Journal
Mediators of inflammation
MicroRNA-125a suppresses cell migration, invasion, and regulates hyaluronic acid synthase 1 expression by targeting signal transducers and activators of transcription 3 in renal cell carcinoma cells.
Journal
Journal of Cellular Biochemistry
ALDH3A1 acts as a prognostic biomarker and inhibits the epithelial mesenchymal transition of oral squamous cell carcinoma through IL-6/STAT3 signaling pathway
Suppression of c-Met-Overexpressing Tumors by a Novel c-Met/CD3 Bispecific Antibody
Journal
Drug Des Devel Ther
MicroRNA-30c-5p ameliorates hypoxia-reoxygenation-induced tubular epithelial cell injury via HIF1α stabilization by targeting SOCS3
Trillin prevents proliferation and induces apoptosis through inhibiting STAT3 nuclear translocation in hepatoma carcinoma cells
Journal
Medical oncology (Northwood, London, England)
Upregulation of KDM6B contributes to lipopolysaccharide-induced anxiety-like behavior via modulation of VGLL4 in mice
Xiaoliu Pingyi Pecipe Inhibits Lung Pre-Metastatic Niche Formation and Prevents Myeloid-Derived Suppressor Cells Recruitment - PMC
Journal
Integrative cancer therapies
Gefitinib represses JAK-STAT signaling activated by CRTC1-MAML2 fusion in mucoepidermoid carcinoma cells
Journal
Current cancer drug targets
lncRNA MIAT targets miR-411-5p/STAT3/PD-L1 axis mediating hepatocellular carcinoma immune response
Journal
International journal of experimental pathology
Species
Homo sapiens, Mus musculus
Role of Notch, IL-1 and leptin expression in colorectal cancer
Majoon Chobchini attenuates arthritis disease severity and RANKL-mediated osteoclastogenesis in rheumatoid arthritis
Polygonatum sibiricum Polysaccharide Inhibited Liver Cancer in a Simulated Tumor Microenvironment by Eliminating TLR4/STAT3 Pathway
Journal
Biological & pharmaceutical bulletin
Morroniside ameliorates lipopolysaccharide-induced inflammatory damage in iris pigment epithelial cells through inhibition of TLR4/JAK2/STAT3 pathway - PMC
Journal
International journal of ophthalmology
Xiaoqinglong decoction suppresses childhood cough variant asthma and inhibited the body inflammatory response by regulating IL-6/STAT3 signalling pathway - PMC
Journal
Annals of medicine and surgery (2012)
PRMT6 methylation of STAT3 regulates tumor metastasis in breast cancer - PMC
Journal
Cell death & disease