VCAM-1-binding peptide targeted cationic liposomes containing NLRP3 siRNA to modulate LDL transcytosis as a novel therapy for experimental atherosclerosis
Journal
Metabolism: clinical and experimental
Inetetamab, a novel anti-HER2 monoclonal antibody, exhibits potent synergistic anticancer effects with cisplatin by inducing pyroptosis in lung adenocarcinoma - PMC
Journal
International journal of biological sciences
Medioresinol as a novel PGC-1 activator prevents pyroptosis of endothelial cells in ischemic stroke through PPAR-GOT1 axis
Alternative polyadenylation trans-factor FIP1 exacerbates UUO/IRI-induced kidney injury and contributes to AKI-CKD transition via ROS-NLRP3 axis
oprC Impairs Host Defense by Increasing the Quorum-Sensing-Mediated Virulence of Pseudomonas aeruginosa
Benzo[a]pyrene induces NLRP1 expression and promotes prolonged inflammasome signaling - PMC
Journal
Frontiers in immunology
Exercise training-attenuated insulin resistance and liver injury in elderly pre-diabetic patients correlates with NLRP3 inflammasome - PMC
Journal
Frontiers in immunology
TLR4 aggravates microglial pyroptosis by promoting DDX3X-mediated NLRP3 inflammasome activation via JAK2/STAT1 pathway after spinal cord injury - PMC
Journal
Clinical and translational medicine
IL-17A-mediated mitochondrial dysfunction induces pyroptosis in colorectal cancer cells and promotes CD8+T-cell tumour infiltration - PMC
Journal
Journal of translational medicine
Filarial thioredoxin reductase exerts anti-inflammatory effects upon lipopolysaccharide induced inflammation in macrophages
Journal
Int J Biol Macromol
Melatonin alleviates doxorubicin-induced cardiotoxicity via inhibiting oxidative stress, pyroptosis and apoptosis by activating Sirt1/Nrf2 pathway
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Protective effect and mechanism of baicalin on lung inflammatory injury in BALB/cJ mice induced by PM2. 5
Journal
Ecotoxicology and environmental safety
Endoplasmic reticulum stress contributes to pyroptosis through NF-B/NLRP3 pathway in diabetic nephropathy
Species
Canis lupus familiaris
Inhibition of SGLT1 protects against glycemic variability-induced cardiac damage and pyroptosis of cardiomyocytes in diabetic mice
GYY4137 alleviates sepsis-induced acute lung injury in mice by inhibiting the PDGFRβ/Akt/NF-κB/NLRP3 pathway
Punicalagin Protects Diabetic Nephropathy by Inhibiting Pyroptosis Based on TXNIP/NLRP3 Pathway
Chlorogenic acid suppresses mitochondrial apoptotic effectors Bax/Bak to counteract Nod-like receptor pyrin domain 3 (NLRP3) inflammasome in thiram exposed chondrocytes
nNovel insights into antidepressant mechanism of Kai Xin San formula: inhibiting NLRP3 inflammasome activation by promoting autophagy
Sophflarine A, a novel matrine-derived alkaloid from Sophora flavescens with therapeutic potential for non-small cell lung cancer through ROS-mediated pyroptosis …
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Chlorogenic acid suppresses miR-460a in the regulation of Bcl-2, causing interleukin-1β reduction in thiram exposed chondrocytes via caspase-3/caspase-7 pathway
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Ginsenoside Rb1 ameliorates cardiotoxicity triggered by aconitine via inhibiting calcium overload and pyroptosis
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Intra-articular Injection of Baicalein Inhibits Cartilage Catabolism and NLRP3 Inflammasome Signaling in a Posttraumatic OA Model
Journal
Oxid Med Cell Longev
Simvastatin Inhibits NLRP3 Inflammasome Activation and Ameliorates Lung Injury in Hyperoxia-Induced Bronchopulmonary Dysplasia via the KLF2-Mediated Mechanism
Journal
Oxidative medicine and cellular longevity
Dual Role of Mitogen-Activated Protein Kinase 8 Interacting Protein-1 in Inflammasome and Pancreatic -Cell Function - PMC
Journal
International journal of molecular sciences
Species
Homo sapiens, Rattus norvegicus
Mallotucin D, a Clerodane Diterpenoid from Croton crassifolius, Suppresses HepG2 Cell Growth via Inducing Autophagic Cell Death and Pyroptosis - PMC
Journal
International journal of molecular sciences
Neural and central mechanisms of kidney fibrosis after relief of ureteral obstruction - PMC
Species
Homo sapiens, Rattus norvegicus
GSDMA3 deficiency reprograms cellular metabolism and modulates BCR signaling in murine B cells - PMC
Cholesterol Induces Pyroptosis and Matrix Degradation via mSREBP1-Driven Endoplasmic Reticulum Stress in Intervertebral Disc Degeneration
Journal
Frontiers in cell and developmental biology
-Caryophyllene Ameliorates MSU-Induced Gouty Arthritis and Inflammation Through Inhibiting NLRP3 and NF-B Signal Pathway: In Silico and In Vivo
Obeticholic Acid Induces Hepatoxicity Via FXR in the NAFLD Mice
Journal
Frontiers in pharmacology
Calcipotriol Inhibits NLRP3 Signal Through YAP1 Activation to Alleviate Cholestatic Liver Injury and Fibrosis
Journal
Frontiers in Pharmacology
ALDH2 attenuates myocardial pyroptosis through breaking down Mitochondrion-NLRP3 inflammasome pathway in septic shock - PMC
Journal
Frontiers in pharmacology
Sodium-Glucose Co-transporter-2 Inhibitor of Dapagliflozin Attenuates Myocardial Ischemia/Reperfusion Injury by Limiting NLRP3 Inflammasome Activation and Modulating Autophagy
Journal
Frontiers in cardiovascular medicine
Endothelial cellreleased extracellular vesicles trigger pyroptosis and vascular inflammation to induce atherosclerosis through the delivery of HIF1AAS2
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Application
WB, IF, IP, CHIP
Intranasal administration of β‐1, 3‐galactosyltransferase 2 confers neuroprotection against ischemic stroke by likely inhibiting oxidative stress and NLRP3 …
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Loganin alleviates sepsis-induced acute lung injury by regulating macrophage polarization and inhibiting NLRP3 inflammasome activation
Fraxin ameliorates lipopolysaccharide-induced acute lung injury in mice by inhibiting the NF-B and NLRP3 signalling pathways.
Journal
International immunopharmacology
3, 4-Benzopyrene (Bap) aggravated abdominal aortic aneurysm formation by targeting pyroptosis in smooth muscle cells through ET-1 mediated NLRP3
Journal
International immunopharmacology
NF-κB p65 and SETDB1 expedite lipopolysaccharide-induced intestinal inflammation in mice by inducing IRF7/NLR-dependent macrophage M1 polarization
Journal
International immunopharmacology
NF-κB p65 and SETDB1 expedite lipopolysaccharide-induced intestinal inflammation in mice by inducing IRF7/NLR-dependent macrophage M1 polarization
Journal
International immunopharmacology
PTP1B Inhibitor Claramine Rescues Diabetes-Induced Spatial Learning and Memory Impairment in Mice
Journal
Molecular neurobiology
Isobavachalcone's Alleviation of Pyroptosis Contributes to Enhanced Apoptosis in Glioblastoma: Possible Involvement of NLRP3
Journal
Molecular neurobiology
The effect of isovitexin on lipopolysaccharide-induced renal injury and inflammation by induction of protective autophagy
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Anemoside B4 alleviates arthritis pain via suppressing ferroptosis-mediated inflammation - PMC
Journal
Journal of cellular and molecular medicine
Activation of adenosine A3 receptor attenuates progression of osteoarthritis through inhibiting the NLRP3/caspase-1/GSDMD induced signalling - PMC
Journal
Journal of cellular and molecular medicine
Increased Circulating ADMA in Young Male Rats Caused Cognitive Deficits and Increased Intestinal and Hippocampal NLRP3 Inflammasome Expression and Microbiota Composition Alterations: Effects of Resveratrol - PMC
Journal
Pharmaceuticals (Basel, Switzerland)
Baicalin inhibited both the Furin/TGFβ1/Smad3/TSP-1 pathway in endothelial cells and the AKT/Ca2+/ROS pathway in platelets to ameliorate inflammatory …
Journal
European journal of pharmacology
Fudosteine attenuates acute lung injury in septic mice by inhibiting pyroptosis via the TXNIP/NLRP3/GSDMD pathway
Journal
European journal of pharmacology
S1P/S1PR2 promote pancreatic stellate cell activation and pancreatic fibrosis in chronic pancreatitis by regulating autophagy and the NLRP3 inflammasome
Journal
Chemico-biological interactions
Downregulation of the NLRP3/Caspse-1 Pathway Ameliorates Ketamine-Induced Liver Injury and Inflammation in Developing Rats
Journal
Molecules (Basel, Switzerland)
LanGui tea, an herbal medicine formula, protects against binge alcohol-induced acute liver injury by activating AMPK-NLRP3 signaling - PMC
LanGui tea, an herbal medicine formula, protects against binge alcohol-induced acute liver injury by activating AMPK-NLRP3 signaling - PMC
MicroRNA-155 suppressed cholesterol-induced matrix degradation, pyroptosis and apoptosis by targeting ROR in nucleus pulposus cells
Journal
Cellular signalling
Chinese Poplar Propolis Inhibits MDA-MB-231 Cell Proliferation in an Inflammatory Microenvironment by Targeting Enzymes of the Glycolytic Pathway
Long Noncoding RNA AC078850.1 Induces NLRP3 Inflammasome-Mediated Pyroptosis in Atherosclerosis by Upregulating ITGB2 Transcription via Transcription Factor HIF-1α - PMC
BRD9 Inhibition Attenuates Matrix Degradation and Pyroptosis in Nucleus Pulposus by Modulating the NOX1/ROS/NF-κB axis
Application
WB, IHC, IF, RT-PCR
Species
Rattus norvegicus,Homo sapiens
Overexpression of TOLLIP Protects against Acute Kidney Injury after Paraquat Intoxication through Inhibiting NLRP3 Inflammasome Activation Modulated by Toll-Like Receptor 2/4 Signaling
Inhibition of CEBPB Attenuates Lupus Nephritis via Regulating Pim-1 Signaling - PMC
Journal
Mediators of inflammation
Salidroside Alleviates Chronic Constriction Injury-Induced Neuropathic Pain and Inhibits of TXNIP/NLRP3 Pathway
Fisetin attenuates arsenic and fluoride subacute co-exposure induced neurotoxicity via regulating TNF- mediated activation of NLRP3 inflammasome
MiR-4953p attenuates cell pyroptosis and endometritis through inhibiting the activation of NLRP3 inflammasome in bovine
Journal
Molecular immunology
Antagonistic effect of selenium on mercuric chloride in the central immune organs of chickens: The role of microRNA-183/135b-FOXO1/TXNIP/NLRP3 inflammasome axis
Journal
Environmental toxicology
Diosmin ameliorates LPS-induced depression-like behaviors in mice: inhibition of inflammation and oxidative stress in the prefrontal cortex
Journal
Brain research bulletin
Suppression of the caspase-1/GSDMD-mediated pyroptotic signaling pathway through dexamethasone alleviates corneal alkali injuries
N-acetylserotonin alleviated the expression of interleukin-1β in retinal ischemia-reperfusion rats via the TLR4/NF-κB/NLRP3 pathway
2-Bromopalmitate decreases spinal inflammation and attenuates oxaliplatin-induced neuropathic pain via reducing Drp1-mediated mitochondrial dysfunction - PMC
Melatonin inhibits vascular endothelial cell pyroptosis by improving mitochondrial function via up-regulation and demethylation of UQCRC1
Journal
Biochemistry and cell biology = Biochimie et biologie cellulaire
Tectoridin alleviates lipopolysaccharide-induced inflammation via inhibiting TLR4-NF-κB/NLRP3 signaling in vivo and in vitro
Journal
Immunopharmacology and immunotoxicology
PHLDA1 Blockade Alleviates Cerebral Ischemia/Reperfusion Injury by Affecting Microglial M1/M2 Polarization and NLRP3 Inflammasome Activation
Proanthocyanidins suppress NLRP3 inflammasome and M1 macrophage polarization to alleviate severe acute pancreatitis in mice
Journal
Journal of biochemical and molecular toxicology
AMPK activation attenuates cancer-induced bone pain by reducing mitochondrial dysfunction-mediated neuroinflammation - PMC
Journal
Acta biochimica et biophysica Sinica
β-hydroxybutyrate impairs monocyte function via the ROS-NLR family pyrin domain-containing three inflammasome (NLRP3) pathway in ketotic cows - PMC
Journal
Frontiers in veterinary science
Celastrol attenuates human parvovirus B19 NS1-induced NLRP3 inflammasome activation in macrophages - PMC
Journal
Molecular medicine reports
Klotho alleviates NLRP3 inflammasome-mediated neuroinflammation in a temporal lobe epilepsy rat model by activating the Nrf2 signaling pathway
Journal
Epilepsy & behavior : E&B
Species
Oryctolagus cuniculus
Vinpocetine Attenuates Ischemic Stroke Through Inhibiting NLRP3 Inflammasome Expression in Mice
Journal
J Cardiovasc Pharmacol .
Quercetin effectively improves LPS-induced intestinal inflammation, pyroptosis, and disruption of the barrier function through the TLR4/NF-B/NLRP3 signaling pathway in vivo and in vitro - PMC
Journal
Food & nutrition research
Preventive effect of dioscin against monosodium urate-mediated gouty arthritis through inhibiting inflammasome NLRP3 and TLR4/NF-κB signaling pathway activation: an in vivo and in vitro study
Long non-coding RNA RP11-490M8.1 inhibits lipopolysaccharide-induced pyroptosis of human umbilical vein endothelial cells via the TLR4/NF-κB pathway
Bakuchiol ameliorates cerebral ischemia-reperfusion injury by modulating NLRP3 inflammasome and Nrf2 signaling
Journal
Respir Physiol Neurobiol
Gastrodin alleviates inflammatory injury of cardiomyocytes in septic shock mice via inhibiting NLRP3 expression
Journal
In vitro cellular & developmental biology. Animal
Prevention of Bleomycin-Induced Pulmonary Inflammation and Fibrosis in Mice by Bilobalide - PMC
Journal
Evidence-based complementary and alternative medicine : eCAM
Protective effects of oridonin against cerebral ischemia/reperfusion injury by inhibiting the NLRP3 inflammasome activation
Protective effects of oridonin against cerebral ischemia/reperfusion injury by inhibiting the NLRP3 inflammasome activation
Overexpression of miR-224-5p alleviates allergic rhinitis in mice via the TLR4/MyD88/NF-κB pathway
N-acetylserotonin alleviates retinal ischemia-reperfusion injury via HMGB1/RAGE/NF-B pathway in rats - PMC
Journal
International journal of ophthalmology
Wedelolactone ameliorates synovial inflammation and cardiac complications in a murine model of collagen-induced arthritis by inhibiting NF-B/NLRP3
Journal
Folia histochemica et cytobiologica
HDAC6 inhibition alleviates acute pulmonary embolism: a possible future therapeutic option
Journal
Folia histochemica et cytobiologica
The inhibitory effect of quercetin-3-glucuronide on pulmonary injury in vitro and in vivo - PMC
Journal
Journal of food and drug analysis