Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-B pathways - PMC
Journal
Military Medical Research
Species
Homo sapiens, Mus musculus
Supramolecular Hydrogel with UltraRapid CellMediated Network Adaptation for Enhancing Cellular Metabolic Energetics and Tissue Regeneration
Journal
Advanced materials (Deerfield Beach, Fla.)
Cellular MembraneEngineered Nanovesicles as ThreeStage Booster to Target Lesion Core
Journal
Advanced materials (Deerfield Beach, Fla.)
HighStrength Smart Microneedles with "Offensive and Defensive" Effects for Intervertebral Disc Repair
Journal
Advanced materials (Deerfield Beach, Fla.)
Role of dendritic cells in MYD88-mediated immune recognition and osteoinduction initiated by the implantation of biomaterials - PMC
Journal
International journal of oral science
A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation
Journal
Nature Communications
Species
Homo sapiens, Mus musculus
Impaired mitochondrial oxidative metabolism in skeletal progenitor cells leads to musculoskeletal disintegration - PMC
Journal
Nature communications
UV-induced reduction in Polycomb repression promotes epidermal pigmentation
Journal
Developmental cell
LYC inhibits the AKT signaling pathway to activate autophagy and ameliorate TGFB-induced renal fibrosis
Early concentrate starter introduction induces rumen epithelial parakeratosis by blocking keratinocyte differentiation with excessive ruminal butyrate
Journal
Journal of advanced research
Hypoxia enhances anti-fibrotic properties of extracellular vesicles derived from hiPSCs via the miR302b-3p/TGF/SMAD2 axis - PMC
Biomimetic Silk Fibroin Hydrogels Strengthened by Silica Nanoparticles Distributed Nanofibers Facilitate Bone Repair
Journal
Advanced healthcare materials
Dual Function of Magnesium in Bone Biomineralization
Journal
Advanced Healthcare Materials
FnHMGB1 Adsorption Behavior Initiates Early Immune Recognition and Subsequent Osteoinduction of Biomaterials
Journal
Advanced healthcare materials
Wireless Electric Cues Mediate Autologous DPSCLoaded Conductive Hydrogel Microspheres to Engineer The ImmunoAngiogenic Niche for Homologous
Journal
Advanced healthcare materials
Species
Homo sapiens,Rattus norvegicus
Antifibrotic Effects of Tetrahedral Framework Nucleic Acids by Inhibiting Macrophage Polarization and Macrophage‐myofibroblast Transition in Bladder Remodeling
Journal
Advanced healthcare materials
Engineering Stem Cell Recruitment and Osteoinduction via Bioadhesive Molecular Mimics to Improve Osteoporotic Bone-Implant Integration - PMC
Journal
Research (Washington, D.C.)
Cadmium exposure triggers osteoporosis in duck via P2X7/PI3K/AKT-mediated osteoblast and osteoclast differentiation
Journal
The Science of the total environment
KMT5A Downregulation Participated In High Glucose-mediated EndMT Via Upregulation of ENO1 Expression in Diabetic Nephropathy
Inulin-like polysaccharide ABWW may impede CCl4 induced hepatic stellate cell activation through mediating the FAK/PI3K/AKT signaling pathway in vitro & in vivo
Journal
Carbohydrate polymers
Biphasic calcium phosphate recruits Tregs to promote bone regeneration
Journal
Acta biomaterialia
NSD2 Modulates Drp1-mediated Mitochondrial Fission in Chronic Renal Allograft Interstitial Fibrosis by methylating STAT1
Journal
Pharmacological research
Species
Homo sapiens,Mus musculus
Loss of Stat3 in Osterix+ cells impairs dental hard tissues development - PMC
Liposomal UHRF1 siRNA shows lung fibrosis treatment potential by regulating fibroblast activation
Cerium oxide nanoparticles-carrying human umbilical cord mesenchymal stem cells counteract oxidative damage and facilitate tendon regeneration - PMC
Journal
Journal of nanobiotechnology
A bacteria-derived tetramerized protein ameliorates nonalcoholic steatohepatitis in mice via binding and relocating acetyl-coA carboxylase
Single-cell RNA-seq analysis reveals that immune cells induce human nucleus pulposus ossification and degeneration - PMC
Journal
Frontiers in immunology
Single-cell RNA sequencing reveals the immune microenvironment and signaling networks in cystitis glandularis - PMC
Journal
Frontiers in immunology
Biological testing of chitosan-collagen-based porous scaffolds loaded with PLGA/Triamcinolone microspheres for ameliorating endoscopic dissection-related stenosis in oesophagus
Construction of tissue-engineered skin with rete ridges using co-network hydrogels of gelatin methacrylated and poly(ethylene glycol) diacrylate
Journal
Mater Sci Eng C Mater Biol Appl
Discovery of the First Subnanomolar PPARα/δ Dual Agonist for the Treatment of Cholestatic Liver Diseases
Journal
Journal of medicinal chemistry
Design, Synthesis, and Biological Evaluation of Triazolone Derivatives as Potent PPARα/δ Dual Agonists for the Treatment of Nonalcoholic Steatohepatitis
Journal
Journal of medicinal chemistry
Biochanin A Ameliorates Nephropathy in High-Fat Diet/Streptozotocin-Induced Diabetic Rats: Effects on NF-kB/NLRP3 Axis, Pyroptosis, and Fibrosis - PMC
Journal
Antioxidants (Basel, Switzerland)
Biochanin A Ameliorates Nephropathy in High-Fat Diet/Streptozotocin-Induced Diabetic Rats: Effects on NF-kB/NLRP3 Axis, Pyroptosis, and Fibrosis - PMC
Journal
Antioxidants (Basel, Switzerland)
Deleterious Role of Th9 Cells in Pulmonary Fibrosis
Substrate stiffness and sequence dependent bioactive peptide hydrogels influence the chondrogenic differentiation of human mesenchymal stem cells
Journal
Journal of materials chemistry. B
Arginase-1 promotes lens epithelial-to-mesenchymal transition in different models of anterior subcapsular cataract - PMC
Journal
Cell communication and signaling : CCS
Formononetin ameliorates isoproterenol induced cardiac fibrosis through improving mitochondrial dysfunction
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Triptolide attenuates pulmonary fibrosis by inhibiting fibrotic extracellular matrix remodeling mediated by MMPs/LOX/integrin
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Disruption of RCAN1.4 expression mediated by YY1/HDAC2 modulates chronic renal allograft interstitial fibrosis - PMC
Journal
Cell death discovery
Species
Homo sapiens, Mus musculus
Design, synthesis and evaluation of novel UDCA-aminopyrimidine hybrids as ATX inhibitors for the treatment of hepatic and pulmonary fibrosis
Journal
European journal of medicinal chemistry
Hollow Hydroxyapatite Microspheres Loaded with rhCXCL13 to Recruit BMSC for Osteogenesis and Synergetic Angiogenesis to Promote Bone Regeneration in Bone Defects - PMC
Journal
International journal of nanomedicine
E2F transcription factor 1 (E2F1) promotes the transforming growth factor TGF-1 induced human cardiac fibroblasts differentiation through promoting the transcription of CCNE2 gene
Biochanin A alleviates unilateral ureteral obstruction-induced renal interstitial fibrosis and inflammation by inhibiting the TGF-1/Smad2/3 and NF-kB/NLRP3 signaling axis in mice
Biochanin A alleviates unilateral ureteral obstruction-induced renal interstitial fibrosis and inflammation by inhibiting the TGF-1/Smad2/3 and NF-kB/NLRP3 signaling axis in mice
Aloin alleviates pathological cardiac hypertrophy via modulation of the oxidative and fibrotic response
Alisol B Alleviates Hepatocyte Lipid Accumulation and Lipotoxicity via Regulating RARα-PPARγ-CD36 Cascade and Attenuates Non-Alcoholic Steatohepatitis in Mice - PMC
Exosomes from Human Umbilical Cord Mesenchymal Stem Cells Facilitates Injured Endometrial Restoring in Early Repair Period through miR-202-3p Mediating …
Journal
Stem cell reviews and reports
Schisantherin A ameliorates liver fibrosis through TGF-β1mediated activation of TAK1/MAPK and NF-κB pathways in vitro and in vivo
TIMP1/CHI3L1 facilitates glioma progression and immunosuppression via NF-B activation
Journal
Biochimica et biophysica acta. Molecular basis of disease
Peiminine regulates bone‐fat balance by canonical Wnt/β‐catenin pathway in an ovariectomized rat model
Journal
Phytotherapy research : PTR
Application
WB, IHC, IF, RT-qPCR
Carvacrol preserves antioxidant status and attenuates kidney fibrosis via modulation of the TGF-1/Smad signaling and inflammation
Neddylation of EphB1 Regulates Its Activity and Associates with Liver Fibrosis - PMC
Journal
International journal of molecular sciences
Eupatilin Ameliorates Hepatic Fibrosis and Hepatic Stellate Cell Activation by Suppressing -catenin/PAI-1 Pathway - PMC
Journal
International journal of molecular sciences
Anti-Adhesive Resorbable Indomethacin/Bupivacaine-Eluting Nanofibers for Tendon Rupture Repair: In Vitro and In Vivo Studies - PMC
Journal
International journal of molecular sciences
Changes in the Expression and Functional Activities of C-X-C Motif Chemokine Ligand 13 (CXCL13) in Hyperplastic Prostate - PMC
Journal
International journal of molecular sciences
Species
Homo sapiens,Rattus norvegicus
Telomerase-mediated immortalization of human vaginal wall fibroblasts derived from patients with pelvic organ prolapse
Journal
Chinese medical journal
Dexamethasone causes calcium deposition and degeneration in human anterior cruciate ligament cells through endoplasmic reticulum stress
Journal
Biochemical Pharmacology
Gut Microbiota Metabolite 3-Indolepropionic Acid Directly Activates Hepatic Stellate Cells by ROS/JNK/p38 Signaling Pathways - PMC
Layered Double Hydroxides-Loaded Sorafenib Inhibit Hepatic Stellate Cells Proliferation and Activation In Vitro and Reduce Fibrosis In Vivo
- PMC
Journal
Frontiers in bioengineering and biotechnology
Calcipotriol Inhibits NLRP3 Signal Through YAP1 Activation to Alleviate Cholestatic Liver Injury and Fibrosis
Journal
Frontiers in Pharmacology
Calcipotriol Inhibits NLRP3 Signal Through YAP1 Activation to Alleviate Cholestatic Liver Injury and Fibrosis
Journal
Frontiers in Pharmacology
ADAMTS8 Promotes Cardiac Fibrosis Partly Through Activating EGFR Dependent Pathway
Journal
Frontiers in cardiovascular medicine
Species
Homo sapiens,Rattus norvegicus
MFGE8 attenuates Ang-II-induced atrial fibrosis and vulnerability to atrial fibrillation through inhibition of TGF-β1/Smad2/3 pathway
Journal
Journal of molecular and cellular cardiology
3D printed-electrospun PCL/hydroxyapatite/MWCNTs scaffolds for the repair of subchondral bone - PMC
Journal
Regenerative biomaterials
Atractylenolide III Ameliorated Autophagy Dysfunction via Epidermal Growth Factor Receptor-Mammalian Target of Rapamycin Signals and Alleviated Silicosis
Journal
Laboratory investigation; a journal of technical methods and pathology
TGF-1 Triggers Salivary Hypofunction via Attenuating Protein Secretion and AQP5 Expression in Human Submandibular Gland Cells
Journal
Journal of proteome research
Myocardin‑related transcription factor A nuclear translocation contributes to mechanical overload‑induced nucleus pulposus fibrosis in rats with intervertebral disc degeneration
Nootkatone confers antifibrotic effect by regulating the TGF-β/Smad signaling pathway in mouse model of unilateral ureteral obstruction
Imperatorin ameliorates kidney injury in diabetic mice by regulating the TGF-/Smad2/3 signaling axis, epithelial-to-mesenchymal transition, and renal inflammation
Journal
European journal of pharmacology
Alternanthera brasiliana L. extract alleviates carbon tetrachloride-induced liver injury and fibrotic changes in mice: Role of matrix metalloproteinases and TGF-β/Smad …
Journal
Journal of ethnopharmacology
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) deletion in myeloid cells augments cholestatic liver injury - PMC
Journal
Scientific reports
Novel CO2-encapsulated Pluronic F127 hydrogel for the treatment of Achilles tendon injury - PMC
Journal
Scientific reports
Tri-Layered Doxycycline-, Collagen- and Bupivacaine-Loaded Poly(lactic-co-glycolic acid) Nanofibrous Scaffolds for Tendon Rupture Repair - PMC
Single-Cell Characterization of the Frizzled 5 (Fz5) Mutant Mouse and Human Persistent Fetal Vasculature (PFV) - PMC
Journal
Investigative ophthalmology & visual science
Exercised accelerated the production of muscle-derived kynurenic acid in skeletal muscle and alleviated the postmenopausal osteoporosis through the Gpr35 …
Journal
Journal of orthopaedic translation
Angiotensin II type-2 receptor attenuates liver fibrosis progression by suppressing IRE1-XBP1 pathway
Journal
Cellular signalling
Species
Homo sapiensMus musculus
The Apelin-APJ axis alleviates LPS-induced pulmonary fibrosis and endothelial mesenchymal transformation in mice by promoting Angiotensin-Converting Enzyme 2
Journal
Cellular signalling
Genipin-crosslinked decellularized annulus fibrosus hydrogels induces tissue-specific differentiation of bone mesenchymal stem cells and intervertebral disc regeneration
Journal
Journal of Tissue Engineering and Regenerative Medicine,
Species
Homo sapiens,Bovine
Protective effect of selenium-enriched green tea on carbon tetrachloride-induced liver fibrosis
Journal
Biological trace element research
Developmental endothelial locus1 promotes osteogenic differentiation and alveolar bone regeneration in experimental periodontitis with type 2 diabetes mellitus
Journal
Journal of periodontal research
Triptolide attenuates cardiac remodeling by inhibiting pyroptosis and EndMT via modulating USP14/Keap1/Nrf2 pathway - PMC
Mitochondrial citrate accumulation triggers senescence of alveolar epithelial cells contributing to pulmonary fibrosis in mice - PMC
IL-27 promotes cardiac fibroblast activation and aggravates cardiac remodeling post myocardial infarction - PMC
IL-27 promotes cardiac fibroblast activation and aggravates cardiac remodeling post myocardial infarction - PMC
SiO2 dust induces inflammation and pulmonary fibrosis in rat lungs through activation of ASMase/Ceramide pathway
Journal
Journal of applied toxicology : JAT
Downregulation of ubiquitin-specific protease 2 possesses prognostic and diagnostic value and promotes the clear cell renal cell carcinoma progression
Journal
Annals of Translational Medicine
Species
Homo sapiens, Mus musculus
A procedure in mice to obtain intact pituitary-infundibulum-hypothalamus preparations: a method to evaluate the reconstruction of hypothalamohypophyseal system
Indocyanine Green Based Photodynamic Therapy for Keloids: Fundamental Investigation and Clinical Improvement
Journal
Photodiagnosis and photodynamic therapy
Exogenous Spermidine Alleviates Diabetic Myocardial Fibrosis Via Suppressing Inflammation and Pyroptosis in db/db Mice - PMC
Journal
Balkan medical journal
Betulinic acid promotes the osteogenic differentiation of human periodontal ligament stem cells by upregulating EGR1
Journal
Acta Biochim Biophys Sin (Shanghai)
NLRC5 deficiency ameliorates cardiac fibrosis in diabetic cardiomyopathy by regulating EndMT through Smad2/3 signaling pathway
Journal
Biochem Biophys Res Commun
Alogliptin alleviates liver fibrosis via suppression of activated hepatic stellate cell.
Journal
Biochemical and biophysical research communications
Baicalein alleviates intrahepatic cholestasis by regulating bile acid metabolism via an FXR-dependent manner
Journal
Biochemical and biophysical research communications
Curcumol alleviates liver fibrosis by inducing endoplasmic reticulum stress-mediated necroptosis of hepatic stellate cells through Sirt1/NICD pathway
HIV Tat Protein Induces Myocardial Fibrosis Through TGF-β1-CTGF Signaling Cascade: A Potential Mechanism of HIV Infection-Related Cardiac Manifestations
Journal
Cardiovasc Toxicol
Ecliptasaponin A attenuates renal fibrosis by regulating the extracellular matrix of renal tubular cells
Journal
In vitro cellular & developmental biology. Animal
Inhibiting KCNMA1-AS1 promotes osteogenic differentiation of HBMSCs via miR-1303/cochlin axis - PMC
Journal
Journal of orthopaedic surgery and research
GATA4 inhibits odontoblastic differentiation of dental pulp stem cells through targeting IGFBP3
Journal
Archives of oral biology
Effects of low level laser on periodontal tissue remodeling in hPDLCs under tensile stress - PMC
Journal
Lasers in medical science
REPIN1 regulates iron metabolism and osteoblast apoptosis in osteoporosis - PMC
Journal
Cell death & disease
UHRF1-mediated ferroptosis promotes pulmonary fibrosis via epigenetic repression of GPX4 and FSP1 genes - PMC
Journal
Cell death & disease