ShortTerm Statin Therapy Induces Hepatic Insulin Resistance Through HNF4/PAQR9/PPM1 Axis Regulated AKT Phosphorylation
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Species
Homo sapiens,Mus musculus
Avermectin inhibits neutrophil extracellular traps release by activating PTEN demethylation to negatively regulate the PI3K-ERK pathway and reducing respiratory burst in carp
Journal
Journal of Hazardous Materials
Chip-DSF: A rapid screening strategy for drug protein targets
Journal
Pharmacological research
New insights into meningitic Escherichia coli infection of brain microvascular endothelial cells from quantitative proteomics analysis.
Journal
Journal of Neuroinflammation
Retrograde regulation of mitochondrial fission and epithelial to mesenchymal transition in hepatocellular carcinoma by GCN5L1
Fibronectin promotes tumor angiogenesis and progression of non-small-cell lung cancer by elevating WISP3 expression via FAK/MAPK/ HIF-1 axis and activating wnt signaling pathway - PMC
Journal
Experimental hematology & oncology
Species
Homo sapiens,Mus musculus
Gossypol overcomes EGFR-TKIs resistance in non-small cell lung cancer cells by targeting YAP/TAZ and EGFRL858R/T790M.
Journal
Biomedicine & pharmacotherapy = Biomédecine & pharmacothérapie
Roxadustat alleviates nitroglycerin-induced migraine in mice by regulating HIF-1/NF-B/inflammation pathway
Journal
Acta pharmacologica Sinica
Glabridin Ameliorates Alcohol-Caused Liver Damage by Reducing Oxidative Stress and Inflammation via p38 MAPK/Nrf2/NF-B Pathway - PMC
ADAMTS-4 enhances oligodendrocyte differentiation and remyelination by cleaving NG2 proteoglycan and attenuating PDGFR signaling
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Effects and Mechanisms of Rhus chinensis Mill. Fruits on Suppressing RANKL-Induced Osteoclastogenesis by Network Pharmacology and Validation in RAW264.7 Cells
Effects of natural 24-epibrassinolide on inducing apoptosis and restricting metabolism in hepatocarcinoma cells
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
ANKRD1 activates the Wnt signaling pathway by modulating CAV3 expression and thus promotes BMSC osteogenic differentiation and bone formation in …
Journal
Biochimica et biophysica acta. Molecular basis of disease
Suppression of trabecular meshwork phagocytosis by norepinephrine is associated with nocturnal increase in intraocular pressure in mice
Journal
Communications biology
Evodiamine alleviates lipopolysaccharide-induced pulmonary inflammation and fibrosis by activating apelin pathway
The mechanism of ginger and its processed products in the treatment of estradiol valerate coupled with oxytocin-induced dysmenorrhea in mice via regulating …
Vaccarin Regulates Diabetic Chronic Wound Healing through FOXP2/AGGF1 Pathways
Journal
International Journal of Molecular Sciences
Specific Forms of Graphene Quantum Dots Induce Apoptosis and Cell Cycle Arrest in Breast Cancer Cells - PMC
Journal
International journal of molecular sciences
Salicylate Sodium Suppresses Monocyte Chemoattractant Protein-1 Production by Directly Inhibiting Phosphodiesterase 3B in TNF-α-Stimulated Adipocytes - PMC
Journal
International journal of molecular sciences
Effects of Sarcoptes scabiei Translationally Controlled Tumor Protein (TCTP) on Histamine Release and Degranulation of KU812 Cells - PMC
Journal
International journal of molecular sciences
The Extracts of Dendrobium Alleviate Dry Eye Disease in Rat Model by Regulating Aquaporin Expression and MAPKs/NF-κB Signalling - PMC
Journal
International journal of molecular sciences
Graphene Oxide Loaded on TiO2-Nanotube-Modified Ti Regulates the Behavior of Human Gingival Fibroblasts - PMC
Journal
International journal of molecular sciences
Suppression of sonic hedgehog pathway-based proliferation in glioblastoma cells by small-size silver nanoparticles in vitro
Journal
Archives of toxicology
Structure-based discovery of neoandrographolide as a novel inhibitor of Rab5 to suppress cancer growth
Journal
Comput Struct Biotechnol J
Hydroxycarboxylic Acid Receptor 2 Is a Zika Virus Restriction Factor That Can Be Induced by Zika Virus Infection Through the IRE1-XBP1 Pathway
Journal
Frontiers in Cellular and Infection Microbiology
Generation of multicellular tumor spheroids with micro-well array for anticancer drug combination screening based on a valuable biomarker of hepatocellular carcinoma - PMC
Journal
Frontiers in bioengineering and biotechnology
Alleviation of Synovial Inflammation of Juanbi-Tang on Collagen-Induced Arthritis and TNF-Tg Mice Model
Journal
Frontiers in Pharmacology
ANGPTL4 Regulates Psoriasis via Modulating Hyperproliferation and Inflammation of Keratinocytes - PMC
Journal
Frontiers in pharmacology
Species
Homo sapiens, Mus musculus
Therapeutic effect of fenofibrate for non-alcoholic steatohepatitis in mouse models is dependent on regime design - PMC
Journal
Frontiers in pharmacology
Characterizations and the Mechanism Underlying Osteogenic Activity of Peptides from Enzymatic Hydrolysates of Stichopus japonicus
Biotransformation of 18β-Glycyrrhetinic Acid by Human Intestinal Fungus Aspergillus niger RG13B1 and the Potential Anti-Inflammatory Mechanism of Its Metabolites
Journal
Journal of agricultural and food chemistry
MAPK/ERK-PK (Ser11) Pathway Regulates Divergent Thermal Metabolism of Two Congeneric Oyster Species
Imperatorin reduces the inflammatory response of atherosclerosis by regulating MAPKs signaling pathway in vivo and in vitro
Journal
International Immunopharmacology
Nuciferine alleviates intestinal inflammation by inhibiting MAPK/NF-κB and NLRP3/Caspase 1 pathways in vivo and in vitro
Journal
International immunopharmacology
Network pharmacology-based strategy to investigate pharmacological mechanisms of Andrographolide for treatment of vascular cognitive impairment
Journal
International immunopharmacology
Knockdown of EIF4G1 in NSCLC induces CXCL8 secretion - PMC
Journal
Frontiers in pharmacology
Comparison of the Antioxidant and Cytoprotective Properties of Extracts from Different Cultivars of Cornus mas L. - PMC
Journal
International journal of molecular sciences
Non-Esterified Fatty Acid Induces ER Stress-Mediated Apoptosis via ROS/MAPK Signaling Pathway in Bovine Mammary Epithelial Cells - PMC
Transcriptome Analysis Reveals That NEFA and β-Hydroxybutyrate Induce Oxidative Stress and Inflammatory Response in Bovine Mammary Epithelial Cells - PMC
Effect of MiR-100-5p on proliferation and apoptosis of goat endometrial stromal cell in vitro and embryo implantation in vivo
Journal
Journal of cellular and molecular medicine
Astragaloside IV improves pulmonary arterial hypertension by increasing the expression of CCN1 and activating the ERK1/2 pathway
Journal
Journal of cellular and molecular medicine
Vaccarin enhances intestinal barrier function in type 2 diabetic mice
Longan (Dimocarpus longan Lour.) Aril ameliorates cognitive impairment in AD mice induced by combination of D-gal/AlCl3 and an irregular diet via RAS/MEK/ERK signaling pathway
Journal
Journal Of Ethnopharmacology
Polysaccharide from Polygala tenuifolia alleviates cognitive decline in Alzheimer's disease mice by alleviating A damage and targeting the ERK pathway
Journal
Journal of ethnopharmacology
The long noncoding RNA TARID regulates the CXCL3/ERK/MAPK pathway in trophoblasts and is associated with preeclampsia - PMC
Journal
Reproductive biology and endocrinology : RB&E
1-2 T static magnetic field combined with Ferumoxytol prevent unloading-induced bone loss by regulating iron metabolism in osteoclastogenesis - PMC
Journal
Journal of orthopaedic translation
Iron overload induces apoptosis of osteoblast cells via eliciting ER stress-mediated mitochondrial dysfunction and p-eIF2α/ATF4/CHOP pathway in vitro
COX-2 is required to mediate crosstalk of ROS-dependent activation of MAPK/NF-κB signaling with pro-inflammatory response and defense-related NO enhancement during challenge of macrophage-like cell line with Giardia duodenalis
Journal
PLoS neglected tropical diseases
N-phenyl pyrazoline derivative inhibits cell aggressiveness and enhances paclitaxel sensitivity of triple negative breast cancer cells - PMC
Journal
Scientific reports
Iodixanol activation of mast cells: implications in the pathogenesis of iodixanol-induced delayed cutaneous adverse reactions
Regulatory mechanism of the Glabrene against nonsmall cell lung cancer by suppressing FGFR3
Journal
Environmental toxicology
Species
Homo sapiens,Mus musculus
Elastin-derived peptides (EDPs) as a potential pro-malignancy factor in human leukemia cell lines
Journal
Immunologic research
Knockdown of GBP1 inhibits BCG-induced apoptosis in macrophage RAW 264.7 cells via p38/JNK pathway
Chlorogenic Acid Inhibits Human Glioma U373 Cell Progression via Regulating the SRC/MAPKs Signal Pathway: Based on Network Pharmacology Analysis
Journal
Drug Des Devel Ther
A Potent EGFR Inhibitor, N-Phenyl Pyrazoline Derivative Suppresses Aggressiveness and Cancer Stem Cell-Like Phenotype of Cervical Cancer Cells - PMC
Journal
Drug design, development and therapy
Ligusticum chuanxiong promotes the angiogenesis of preovulatory follicles (F1-F3) in late-phase laying hens
TRPM4 mRNA stabilization by METTL3-mediated m6A modification promotes calcific aortic valve inflammation - PMC
Huanglian Jiedu decoction alleviates neurobehavioral damage in mice with chronic alcohol exposure through the RAS-RAF-MEK-ERK pathway - PMC
Oridonin Attenuates Thioacetamide-Induced Osteoclastogenesis Through MAPK/NF-κB Pathway and Thioacetamide-Inhibited Osteoblastogenesis Through …
Journal
Calcified tissue international
Species
Mus musculus,Rattus norvegicus
Possible mechanism of CHI3L1 promoting tonsil lymphocytes proliferation in children with obstructive sleep apnea syndrome
ERK inhibition aids IFN- promoter activation during EV71 infection by blocking CRYAB degradation in SH-SY5Y cells
Journal
Pathogens and disease
C/EBP-β contributes to pig endometrial LE receptivity by targeting cell remodeling genes during implantation
Journal
Reproduction (Cambridge, England)
Antagonistic effects of N-acetylcysteine on lead-induced apoptosis and oxidative stress in chicken embryo fibroblast cells - PMC
YAP confers resistance to vandetanib in medullary thyroid cancer
Journal
Biochemistry and cell biology = Biochimie et biologie cellulaire
The Anti-Apoptotic Role of COX-2 during In Vitro Infection of Human Intestinal Cell Line by Giardia duodenalis and The Potential Regulators
Journal
Infection and immunity
The polysaccharide from Camellia oleifera fruit shell enhances immune responses via activating MAPKs and NF-κB signaling pathways in RAW264.7 macrophages - PMC
Journal
Food & nutrition research
Gas chromatography (GC) fingerprinting and immunomodulatory activity of polysaccharide from the rhizome of Menispermum dauricum DC - PMC
Immunoenhancement activity of Bletilla striata polysaccharide through MAPK and NF-κB signalling pathways in vivo and in vitro
ZBTB20 suppresses tumor growth in glioblastoma through activating the TET1/FAS/caspase-3 pathway - PMC
Species
Oryctolagus cuniculus
PP2Ac knockdown attenuates lipotoxicity-induced pancreatic -cell dysfunction and apoptosis - PMC
Journal
Experimental and therapeutic medicine
Effects of -asarone on spatial learning and memory impairment by exhaustive exercise-induced fatigue: Role of NR-CaMKII-ERK/CREB signal in hippocampus of rats
Journal
Behavioural brain research
Protective Effects of Anwulignan against HCl/Ethanol-Induced Acute Gastric Ulcer in Mice
Journal
Evid Based Complement Alternat Med
Schisandrin B inhibits α-melanocyte-stimulating hormone-induced melanogenesis in B16F10 cells via downregulation of MAPK and CREB signaling pathways
Journal
Bioscience, biotechnology, and biochemistry
SDC1 knockdown induces epithelial–mesenchymal transition and invasion of gallbladder cancer cells via the ERK/Snail pathway
Combining an in silico approach with an animal experiment to investigate the protective effect of troxerutin for treating acute lung injury
Journal
BMC complementary and alternative medicine