Bead-jet printing enabled sparse mesenchymal stem cell patterning augments skeletal muscle and hair follicle regeneration - PMC
Journal
Nature communications
Resveratrol ameliorates polycystic ovary syndrome via transzonal projections within oocyte-granulosa cell communication
A T-cell independent universal cellular therapy strategy through antigen depletion
Modified CFBP-bFGF targeting to ischemic brain promoted the functional recovery of cerebral ischemia
Journal
Journal of controlled release : official journal of the Controlled Release Society
Splicing factor SRSF1 promotes breast cancer progression via oncogenic splice switching of PTPMT1
Journal
J Exp Clin Cancer Res
MORTALIN-Ca 2+ axis drives innate rituximab resistance in diffuse large B-cell lymphoma
Lenvatinib for effectively treating antiangiogenic drug-resistant nasopharyngeal carcinoma - PMC
Journal
Cell death & disease
Species
Homo sapiensMus musculus
Controlled release of dopamine coatings on titanium bidirectionally regulate osteoclastic and osteogenic response behaviors
Journal
Materials science & engineering. C, Materials for biological applications
Depletion of LOXL2 improves respiratory capacity: From air-breathing fish to mammal under hypoxia
Journal
International journal of biological macromolecules
LTB4R Promotes the Occurrence and Progression of Clear Cell Renal Cell Carcinoma (ccRCC) by Regulating the AKT/mTOR Signaling Pathway - PMC
κ-Opioid Receptors Improve Vascular Endothelial Dysfunction in Salt-Sensitive Hypertension via PI3K/Akt/eNOS Signaling Pathway - PMC
Journal
Oxidative medicine and cellular longevity
Nucleosome remodeling and deacetylation complex and MBD3 influence mouse embryonic stem cell naïve pluripotency under inhibition of protein kinase C - PMC
Journal
Cell death discovery
Activation of the CD200/CD200R1 axis attenuates neuroinflammation and improves postoperative cognitive dysfunction via the PI3K/Akt/NF-B signaling pathway in
Journal
Inflammation research : official journal of the European Histamine Research Society ... [et al.]
Research and experimental verification of the molecular mechanism of berberine in improving premature ovarian failure based on network pharmacology
Effects and Mechanisms of Rhus chinensis Mill. Fruits on Suppressing RANKL-Induced Osteoclastogenesis by Network Pharmacology and Validation in RAW264.7 Cells
Sophflarine A, a novel matrine-derived alkaloid from Sophora flavescens with therapeutic potential for non-small cell lung cancer through ROS-mediated pyroptosis …
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Overexpression of GATA5 Inhibits Prostate Cancer Progression by Regulating PLAGL2 via the FAK/PI3K/AKT Pathway
Increased Expression of Integrin Alpha 6 in Nucleus Pulposus Cells in Response to High Oxygen Tension Protects against Intervertebral Disc Degeneration
Journal
Oxid Med Cell Longev
Long noncoding RNA TCL6 binds to miR‐106a‐5p to regulate hepatocellular carcinoma cells through PI3K/AKT signaling pathway
Journal
Journal of cellular physiology
Isobutyric acid promotes colorectal cancer metastasis through activating RACK1
Loss of PR55α promotes proliferation and metastasis by activating MAPK/AKT signaling in hepatocellular carcinoma
Delivery of mesenchymal stem cells-derived extracellular vesicles with enriched miR-185 inhibits progression of OPMD
Journal
Artificial cells, nanomedicine, and biotechnology
Astaxanthin slows down skeletal muscle atrophy in H22 tumor-bearing mice during sorafenib treatment by modulating the gut microbiota
Notopterol Suppresses IL-17-Induced Proliferation and Invasion of A549 Lung Adenocarcinoma Cells via Modulation of STAT3, NF-B, and AP-1 Activation - PMC
Journal
International journal of molecular sciences
Unraveling Connective Tissue Growth Factor as a Therapeutic Target and Assessing Kahweol as a Potential Drug Candidate in Triple-Negative Breast Cancer Treatment - PMC
Journal
International journal of molecular sciences
OBHS Drives Abnormal Glycometabolis Reprogramming via GLUT1 in Breast Cancer - PMC
Journal
International journal of molecular sciences
Mallotucin D, a Clerodane Diterpenoid from Croton crassifolius, Suppresses HepG2 Cell Growth via Inducing Autophagic Cell Death and Pyroptosis - PMC
Journal
International journal of molecular sciences
Ontogenetic Changes in the Expression of the Lin28 Protein in the Rat Hypothalamic Tuberal Nuclei - PMC
Journal
International journal of molecular sciences
Changes in the Expression and Functional Activities of C-X-C Motif Chemokine Ligand 13 (CXCL13) in Hyperplastic Prostate - PMC
Journal
International journal of molecular sciences
Species
Homo sapiens,Rattus norvegicus
Pan-mTOR inhibitors sensitize the senolytic activity of navitoclax via mTORC2 inhibition-mediated apoptotic signaling
Journal
Biochemical pharmacology
SHIP1 Activator AQX-1125 Regulates Osteogenesis and Osteoclastogenesis Through PI3K/Akt and NF-κb Signaling
Journal
Frontiers in cell and developmental biology
WTD Attenuating Rheumatoid Arthritis via Suppressing Angiogenesis and Modulating the PI3K/AKT/mTOR/HIF-1α Pathway
Molecular Mechanism of Gelsemium elegans Benth. against Neuropathic Pain Based on Network Pharmacology and Experimental Evidence
Journal
Frontiers in pharmacology
Protective effect of Astragalus membranaceus and Astragaloside IV in sepsis-induced acute kidney injury - PMC
Species
Homo sapiens, Mus musculus
Long-Time Instead of Short-Time Exposure in Vitro and Administration in Vivo of Ochratoxin A Is Consistent in Immunosuppression
Journal
Journal of agricultural and food chemistry
Determining the mechanism of pulsatilla decoction for treating gastric cancer: a network pharmacology-based study - PMC
Journal
Frontiers in oncology
Apoptosis induction in human prostate cancer cells related to the fatty acid metabolism by wogonin-mediated regulation of the AKT-SREBP1-FASN signaling network
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Carnosic Acid Induces Apoptosis and Inhibits Akt/mTOR Signaling in Human Gastric Cancer Cell Lines
Journal
Pharmaceuticals (Basel)
Epimedii Folium and Curculiginis Rhizoma ameliorate lipopolysaccharides-induced cognitive impairment by regulating the TREM2 signaling pathway
Loureirin B attenuates insulin resistance in HepG2 cells by regulating gluconeogenesis signaling pathway
The therapeutic mechanism of PuRenDan for the treatment of diabetic nephropathy: Network pharmacology and experimental verification
Journal
Journal of ethnopharmacology
Efficacy of curculigoside in protecting against ischemic brain injury through regulation of oxidative stress and NF-κB and PI3K/Akt expression
Journal
Journal of ethnopharmacology
Corneal denervation causes epithelial apoptosis through inhibiting NAD+ biosynthesis
Journal
Investigative ophthalmology & visual science
DHCR7 promotes tumorigenesis via activating PI3K/AKT/mTOR signalling pathway in bladder cancer
Journal
Cellular Signalling
Koumine induces apoptosis in Cyprinus carpio liver cells by regulating JAK-STAT and p53 signaling pathways
Journal
Fish & shellfish immunology
Isocitrate dehydrogenase 2 regulates the proliferation of triple-negative breast cancer through the ferroptosis pathway - PMC
Journal
Scientific reports
Developmental toxicity window of fetal testicular injury in offspring mice induced by prenatal amoxicillin exposure at different time, doses and courses
Journal
Toxicology letters
Mechanism of M2 macrophages modulating astrocyte polarization through the TGF-β/PI3K/Akt pathway
Journal
Immunology letters
Interpreting the Pharmacological Mechanisms of Sho-saiko-to on Thyroid Carcinoma through Combining Network Pharmacology and Experimental Evaluation
Overexpressed lncRNA FTX promotes the cell viability, proliferation, migration and invasion of renal cell carcinoma via FTX/miR-4429/UBE2C axis - PMC
Species
Homo sapiens, Mus musculus
Blood RNAsequencing analysis in acrylamideinduced neurotoxicity and depressive symptoms in rats
Journal
Environmental toxicology
An investigation into the mechanism of nobiletin's inhibition of papillary thyroid cancer using network pharmacology analysis and experimental pharmacology
Journal
European review for medical and pharmacological sciences
Knockdown of FUT11 inhibits the progression of gastric cancer via the PI3K/AKT pathway - PMC
P2RY2 alleviates cerebral ischemia-reperfusion injury by inhibiting YAP phosphorylation and reducing mitochondrial fission
Mitochondria-specific peptide amphiphiles induce mitochondrial dysfunction and peripheral T-cell lymphomas (PTCL) damage - PMC
Journal
Annals of translational medicine
Schisandra chinensis acidic polysaccharide partialy reverses acetaminophen-induced liver injury in mice
Journal
Journal of pharmacological sciences
Upregulated lnc‐HZ02 and miR‐hz02 inhibited migration and invasion by downregulating the FAK/SRC/PI3K/AKT pathway in BPDE‐treated trophoblast cells
Journal
Journal of biochemical and molecular toxicology
Qing Zao Fang (QZF) Alleviates the Inflammatory Microenvironment of the Submandibular Gland in Sjögren's Syndrome Based on the PI3K/Akt/HIF-1 α /VEGF Signaling Pathway
Autophagy inhibition mediated by trillin promotes apoptosis in hepatocellular carcinoma cells via activation of mTOR/STAT3 signaling
Journal
Naunyn-Schmiedeberg's archives of pharmacology
MicroRNA-27b-3p inhibits the proliferation and invasion of cutaneous squamous cell carcinoma by targeting EGFR and MMP-13
miR-5590-3p inhibits the proliferation and metastasis of renal cancer cells by targeting ROCK2 to inhibit proliferation, migration and invasion - PMC
Mechanism underlying the effect of Pulsatilla decoction in hepatocellular carcinoma treatment: a network pharmacology and in vitro analysis - PMC
Journal
BMC complementary medicine and therapies
Nucleoporin 37 promotes the cell proliferation, migration, and invasion of gastric cancer through activating the PI3K/AKT/mTOR signaling pathway
Journal
In Vitro Cell Dev Biol Anim
Autophagy inhibitors alleviate Japanese encephalitis virus-induced cerebral inflammation in mice
Journal
Archives of virology
Calycosin attenuates pulmonary fibrosis by the epithelial-mesenchymal transition repression upon inhibiting the AKT/GSK3β/β-catenin signaling pathway
Lactiplantibacillus plantarum NKK20 Increases Intestinal Butyrate Production and Inhibits Type 2 Diabetic Kidney Injury through PI3K/Akt Pathway - PMC
Journal
Journal of diabetes research
Identification of XAF1 as an endogenous AKT inhibitor
ChemR23 activation attenuates cognitive impairment in chronic cerebral hypoperfusion by inhibiting NLRP3 inflammasome-induced neuronal pyroptosis - PMC
Journal
Cell death & disease
Species
Rattus norvegicus, Homo sapiens
TJZYF Improves Endometrial Receptivity through Regulating VEGF and PI3K/AKT Signaling Pathway - PMC
Journal
BioMed research international
Effect of methanol-ethyl acetate partitioned fractions from Descurainia sophia on proliferation and apoptosis of human non-small cell lung cancer H1975 cells
Journal
Nan fang yi ke da xue xue bao = Journal of Southern Medical University