LINC01852 inhibits the tumorigenesis and chemoresistance in colorectal cancer by suppressing SRSF5-mediated alternative splicing of PKM - PMC
Multi-dimensional single-cell characterization revealed suppressive immune microenvironment in AFP-positive hepatocellular carcinoma - PMC
UBE2M-mediated neddylation of TRIM21 regulates obesity-induced inflammation and metabolic disorders
Multiomic analysis of cervical squamous cell carcinoma identifies cellular ecosystems with biological and clinical relevance
DOCK2 regulates antifungal immunity by regulating RAC GTPase activity
Journal
Cellular & molecular immunology
TS2021, a thirdgeneration oncolytic adenovirus that carried Ki67 promoter, TGF2 5 UTR, and IL 15 against experimental glioblastoma
Journal
Journal of medical virology
Species
Bos taurus,Homo sapiens
Licochalcone A plays dual antiviral roles by inhibiting RSV and protecting against host damage
Journal
Journal of medical virology
Proper RPA acetylation promotes accurate DNA replication and repair
Journal
Nucleic acids research
Comprehensive proteogenomic characterization of early duodenal cancer reveals the carcinogenesis tracks of different subtypes - PMC
Journal
Nature communications
The structural basis of the pH-homeostasis mediated by the Cl-/HCO3- exchanger, AE2 - PMC
Journal
Nature communications
Deciphering genetic causes for sex differences in human health through drug metabolism and transporter genes - PMC
Journal
Nature communications
Multiplex base editing to convert TAG into TAA codons in the human genome - PMC
Journal
Nature communications
Yin Yang 1Induced Long Noncoding RNA DUXAP9 Drives the Progression of Oral Squamous Cell Carcinoma by Blocking CDK1Mediated EZH2 Degradation
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
MSL1 Promotes Liver Regeneration by Driving Phase Separation of STAT3 and Histone H4 and Enhancing Their Acetylation
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Inhibiting the IRE1α Axis of the Unfolded Protein Response Enhances the Antitumor Effect of AZD1775 in TP53 Mutant Ovarian Cancer - PMC
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Enzyme-like biomimetic oral-agent enabling modulating gut microbiota and restoring redox homeostasis to treat inflammatory bowel disease - PMC
Journal
Bioactive materials
Illumination of Hydroxyl Radical in Kidney Injury and High-Throughput Screening of Natural Protectants Using A Fluorescent/Photoacoustic Probe
NU6300 covalently reacts with cysteine-191 of gasdermin D to block its cleavage and palmitoylation - PMC
Pregnenolone 16-carbonitrile Negatively Regulates Hippocampal Cytochrome P450 Enzymes and Ameliorates Phenytoin-induced Hippocampal
Journal
Journal of pharmaceutical analysis
Circular RNA FEACR inhibits ferroptosis and alleviates myocardial ischemia/reperfusion injury by interacting with NAMPT - PMC
Journal
Journal of biomedical science
Original research: BRD4 inhibition impairs DNA mismatch repair, induces mismatch repair mutation signatures and creates therapeutic vulnerability to immune checkpoint blockade in MMR-proficient tumors - PMC
Journal
Journal for immunotherapy of cancer
Surface-tethered ROS-responsive micelle backpacks for boosting mesenchymal stem cell vitality and modulating inflammation in ischemic stroke treatment
Journal
Journal of controlled release : official journal of the Controlled Release Society
FnHMGB1 Adsorption Behavior Initiates Early Immune Recognition and Subsequent Osteoinduction of Biomaterials
Journal
Advanced healthcare materials
An H2R-dependent medial septum histaminergic circuit mediates feeding behavior
Journal
Current biology : CB
HNRNPK/CLCN3 axis facilitates the progression of LUAD through CAF-tumor interaction - PMC
Journal
International journal of biological sciences
FIBP interacts with transcription factor STAT3 to induce EME1 expression and drive radioresistance in lung adenocarcinoma - PMC
Journal
International journal of biological sciences
Integrative Analyses of m6A Regulators Identify that METTL3 is Associated with HPV Status and Immunosuppressive Microenvironment in HPV-related Cancers - PMC
Journal
International journal of biological sciences
Species
Homo sapiens, Mus musculus
Real-ambient particulate matter exposure induced FGFR1 methylation contributes to cardiac dysfunction by altering cardiac lipid metabolism
Journal
The Science of the total environment
MKL-1 suppresses ferroptosis by activating system Xc- and increasing glutathione synthesis - PMC
Journal
International journal of biological sciences
Codelivery of adavosertib and olaparib by tumor-targeting nanoparticles for augmented efficacy and reduced toxicity
Journal
Acta biomaterialia
Bioinspired Nanospheres as Anti-inflammation and Antisenescence Interfacial Biolubricant for Treating Temporomandibular Joint Osteoarthritis
Journal
ACS applied materials & interfaces
Multi-omics analysis of attenuated variant reveals potential evaluation marker of host damaging for SARS-CoV-2 variants
Journal
Science China. Life sciences
Species
Chlorocebus aethiops,Homo sapiens
Functional characterization of novel NPRL3 mutations identified in three families with focal epilepsy
Journal
Science China. Life sciences
Tumor-targeted delivery of lnc antisense RNA against RCAS1 by live-attenuated tryptophan-auxotrophic Salmonella inhibited 4T1 breast tumors and metastasis in mice - PMC
Journal
Molecular therapy. Nucleic acids
The SMARCA4R1157W mutation facilitates chromatin remodeling and confers PRMT1/SMARCA4 inhibitors sensitivity in colorectal cancer - PMC
Journal
NPJ precision oncology
Arginine methyltransferase PRMT5 methylates and destabilizes Mxi1 to confer radioresistance in non-small cell lung cancer
USP7-mediated ER stabilization mitigates ROS accumulation and promotes osimertinib resistance by suppressing PRDX3 SUMOylation in non-small cell lung
Platelet Membrane-Coated Bio-Nanoparticles of Indocyanine Green/Elamipretide for NIR Diagnosis and Antioxidant Therapy in Acute Kidney Injury
Journal
Acta Biomaterialia
Ultrastructural and proteomic profiling of mitochondria-associated endoplasmic reticulum membranes reveal aging signatures in striated muscle
Journal
Cell death & disease
The interaction between STING and NCOA4 exacerbates lethal sepsis by orchestrating ferroptosis and inflammatory responses in macrophages - PMC
Journal
Cell death & disease
Blockade of the NLRP3/caspase-1 axis attenuates ketamine-induced hippocampus pyroptosis and cognitive impairment in neonatal rats
Journal
J Neuroinflammation
Fusobacterium nucleatum promotes colorectal cancer metastasis through miR-1322/CCL20 axis and M2 polarization
Addressing the Enzyme-independent tumor-promoting function of NAMPT via PROTAC-mediated degradation
Journal
Cell chemical biology
Effects of glufosinate-ammonium on male reproductive health: Focus on epigenome and transcriptome in mouse sperm
Marsdenia tenacissima enhances immune response of tumor infiltrating T lymphocytes to colorectal cancer - PMC
Journal
Frontiers in immunology
AGO4 suppresses tumor growth by modulating autophagy and apoptosis via enhancing TRIM21-mediated ubiquitination of GRP78 in a p53-independent manner
GLI1 facilitates collagen-induced arthritis in mice by collaborative regulation of DNA methyltransferases - PMC
CircZNF609 regulates pulmonary fibrosis via miR-145-5p/KLF4 axis and its translation function - PMC
Journal
Cellular & molecular biology letters
Astaxanthin alleviates PM2.5-induced cardiomyocyte injury via inhibiting ferroptosis - PMC
Journal
Cellular & molecular biology letters
Ectoderm-derived frontal bone mesenchymal stem cells promote traumatic brain injury recovery by alleviating neuroinflammation and glutamate excitotoxicity partially via FGF1 - PMC
Journal
Stem cell research & therapy
Clickable Photoreactive ATP-Affinity Probe for Global Profiling of ATP-Binding Proteins
Journal
Analytical chemistry
Placental Alkaline Phosphatase Promotes Zika Virus Replication by Stabilizing Viral Proteins through BIP
CircZXDC Promotes Vascular Smooth Muscle Cell Transdifferentiation via Regulating miRNA-125a-3p/ABCC6 in Moyamoya Disease - PMC
LTB4R Promotes the Occurrence and Progression of Clear Cell Renal Cell Carcinoma (ccRCC) by Regulating the AKT/mTOR Signaling Pathway - PMC
Capsaicin orchestrates metastasis in gastric cancer via modulating expression of TRPV1 channels and driving gut microbiota disorder - PMC
Journal
Cell communication and signaling : CCS
Transgenerational inheritance of adrenal steroidogenesis inhibition induced by prenatal dexamethasone exposure and its intrauterine mechanism - PMC
Journal
Cell communication and signaling : CCS
NEK8 regulates colorectal cancer progression via phosphorylating MYC - PMC
Journal
Cell communication and signaling : CCS
Triptolide attenuates pulmonary fibrosis by inhibiting fibrotic extracellular matrix remodeling mediated by MMPs/LOX/integrin
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Endoplasmic reticulum stress-triggered ferroptosis via the XBP1-Hrd1-Nrf2 pathway induces EMT progression in diabetic nephropathy.
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Areca catechu L. ameliorates chronic unpredictable mild stress-induced depression behavior in rats by the promotion of the BDNF signaling pathway
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Clostridium butyricum and Clostridium tyrobutyricum: angel or devil for necrotizing enterocolitis? - PMC
κ-Opioid Receptors Improve Vascular Endothelial Dysfunction in Salt-Sensitive Hypertension via PI3K/Akt/eNOS Signaling Pathway - PMC
Journal
Oxidative medicine and cellular longevity
Atheroprotective mechanism by which folic acid regulates monocyte subsets and function through DNA methylation
Journal
Clinical epigenetics
Species
Homo sapiens, Mus musculus
Histone deacetylase 3 deletion in alveolar type 2 epithelial cells prevents bleomycin-induced pulmonary fibrosis - PMC
Journal
Clinical epigenetics
HNRNPC, a predictor of prognosis and immunotherapy response based on bioinformatics analysis, is related to proliferation and invasion of NSCLC cells - PMC
Journal
Respiratory research
Hexavalent chromium triggers hepatocytes premature senescence via the GATA4/NF-B signaling pathway mediated by the DNA damage response
Journal
Ecotoxicology and environmental safety
Species
Homo sapiens, Mus musculus
HES1 promotes aerobic glycolysis and cancer progression of colorectal cancer via IGF2BP2-mediated GLUT1 m6A modification - PMC
Journal
Cell death discovery
Dual-targeting compounds possessing enhanced anticancer activity via microtubule disruption and histone deacetylase inhibition
Journal
European journal of medicinal chemistry
Resveratrol improves meat quality traits by activating the lncRNAs-KEAP1-NRF2 axis in pigs
Gut microbiota regulates hepatic ischemia-reperfusion injury-induced cognitive dysfunction via the HDAC2-ACSS2 axis in mice - PMC
Journal
CNS neuroscience & therapeutics
miR-129-5p targets FEZ1/SCOC/ULK1/NBR1 complex to restore neuronal function in mice with post-stroke depression
Suppression of lncRNA Gm47283 attenuates myocardial infarction via miR-706 / Ptgs2 /ferroptosis axis
CTSV (cathepsin V) promotes bladder cancer progression by increasing NF-κB activity
Regulating COX10-AS1/miR-142-5p/PAICS axis inhibits the proliferation of non-small cell lung cancer
Role of GSDM family members in airway epithelial cells of lung diseases: a systematic and comprehensive transcriptomic analysis
Journal
Cell biology and toxicology
Role of GSDM family members in airway epithelial cells of lung diseases: a systematic and comprehensive transcriptomic analysis
Journal
Cell biology and toxicology
Taurohyodeoxycholic acid alleviates trinitrobenzene sulfonic acid induced ulcerative colitis via regulating Th1/Th2 and Th17/Treg cells balance
CREBH knockout accelerates hepatic fibrosis in mouse models of diet-induced nonalcoholic fatty liver disease
nNovel insights into antidepressant mechanism of Kai Xin San formula: inhibiting NLRP3 inflammasome activation by promoting autophagy
Zuogui Pill Disrupt the Malignant Cycle in Breast Cancer Bone Metastasis through the Piezo1-Notch-1-GPX4 Pathway and Active Molecules Fishing
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Ban-xia-xie-xin-tang ameliorates hepatic steatosis by regulating Cidea and Cidec expression in HFD-fed mice
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
PTP1B knockdown alleviates BMSCs senescence via activating AMPK-mediated mitophagy and promotes osteogenesis in senile osteoporosis
Journal
Biochimica et biophysica acta. Molecular basis of disease
Gambogic Acid Induces Pyroptosis of Colorectal Cancer Cells through the GSDME-Dependent Pathway and Elicits an Antitumor Immune Response - PMC
Species
Homo sapiens, Mus musculus
DHX37 Is a Promising Prognostic Biomarker and a Therapeutic Target for Immunotherapy and Chemotherapy in HCC - PMC
STING Contributes to Cancer-Induced Bone Pain by Promoting M1 Polarization of Microglia in the Medial Prefrontal Cortex - PMC
Mechanism of TCF21 Downregulation Leading to Immunosuppression of Tumor-Associated Macrophages in Non-Small Cell Lung Cancer - PMC
Borneol-modified PEGylated graphene oxide as a nanocarrier for brain-targeted delivery of ginsenoside Rg1 against depression
Journal
International journal of pharmaceutics
Isobutyric acid promotes colorectal cancer metastasis through activating RACK1
Heat stress induced IPEC‐J2 cells barrier dysfunction through endoplasmic reticulum stress mediated apoptosis by p‐eif2α/CHOP pathway
Journal
Journal of cellular physiology
Total saponins of panax ginseng via the CX3CL1/CX3CR1 axis attenuates neuroinflammation and exerted antidepressant‐like effects in chronic unpredictable mild …
Journal
Phytotherapy research : PTR
Latex Derived from Ficus carica L. Inhibited the Growth of NSCLC by Regulating the Caspase/Gasdermin/AKT Signaling Pathway
Differential requirements for different subfamilies of the mammalian SWI/SNF chromatin remodeling enzymes in myoblast differentiation
Journal
Biochimica et biophysica acta. Gene regulatory mechanisms
Targeting HNRNPA2B1 inhibits enterovirus 71 replication in SK-N-SH cells - PMC
Aloe-Emodin Ameliorates Cecal Ligation and Puncture-Induced Sepsis
Journal
International journal of molecular sciences
Application
ELISA, WB, IHC
Comparison of Multiple Strategies for Precision Transgene Knock-In in Gallus gallus Genome via Microhomology-Mediated End Joining - PMC
Journal
International journal of molecular sciences
Differential Contributions of mSWI/SNF Chromatin Remodeler Sub-Families to Myoblast Differentiation - PMC
Journal
International journal of molecular sciences
Activation of Gq-Coupled Receptors in Astrocytes Restores Cognitive Function in Alzheimers Disease Mice Model - PMC
Journal
International journal of molecular sciences
Tceal7 Regulates Skeletal Muscle Development through Its Interaction with Cdk1 - PMC
Journal
International journal of molecular sciences
siRNA-Mediated Timp1 Silencing Inhibited the Inflammatory Phenotype during Acute Lung Injury - PMC
Journal
International journal of molecular sciences
Identification and Validation of TRIM25 as a Glucose Metabolism Regulator in Prostate Cancer - PMC
Journal
International journal of molecular sciences
ARP2/3 Regulates Fatty Acid Synthesis by Modulating Lipid Droplets Motility - PMC
Journal
International journal of molecular sciences
Mir-4728 is a Valuable Biomarker for Diagnostic and Prognostic Assessment of HER2-Positive Breast Cancer
Journal
Frontiers in molecular biosciences
The mitochondrial Cu+ transporter PiC2 (SLC25A3) is a target of MTF1 and contributes to the development of skeletal muscle in vitro - PMC
Journal
Frontiers in molecular biosciences
Species
Mus musculus,Homo sapiens
Long non-coding RNA MIAT is involved in the regulation of pyroptosis in diabetic cardiomyopathy via targeting miR-214-3p
CircZCCHC2 decreases pirarubicin sensitivity and promotes triple-negative breast cancer development via the miR-1200/TPR axis - PMC
SARS-CoV-2 Nsp15 suppresses type I interferon production by inhibiting IRF3 phosphorylation and nuclear translocation - PMC
Daughter cell fate choice instructed preemptively by mother cells facing nutrient limitation - PMC
Exploring the potential molecular mechanism of trastuzumab-induced cardiotoxicity based on RNA sequencing and bioinformatics analysis
Journal
Biochemical pharmacology
Downregulation of UBE4B promotes CNS axon regrowth and functional recovery after stroke - PMC
ZIP11 Regulates Nuclear Zinc Homeostasis in HeLa Cells and Is Required for Proliferation and Establishment of the Carcinogenic Phenotype - PMC
Journal
Frontiers in cell and developmental biology
Fucose ameliorates the proinflammatory property of Fusobacterium nucleatum in colitis via altering its metabolism - PMC
Journal
Frontiers in cellular and infection microbiology
Mycobacterium tuberculosis Rv0790c inhibits the cellular autophagy at its early stage and facilitates mycobacterial survival - PMC
Journal
Frontiers in cellular and infection microbiology
Acidovorax citrulli type III effector AopU interferes with plant immune responses and interacts with a watermelon E3 ubiquitin ligase - PMC
Journal
Frontiers in microbiology
Species
Acidovorax citrulli
Dietary intervention reprograms bone marrow cellular signaling in obese mice - PMC
Journal
Frontiers in endocrinology
Salvianolic Acid Ameliorates Pressure Overload-Induced Cardiac Endothelial Dysfunction via Activating HIF1/HSF1/CD31 Pathway
Journal
The American journal of Chinese medicine
Deciphering the Mechanism of Bushen Huoxue Decotion on Decidualization by Intervening Autophagy via AMPK/mTOR/ULK1: A Novel Discovery for URSA Treatment
Journal
Frontiers in pharmacology
Hydroxy-Safflower Yellow A Alleviates Osteoporosis in Ovariectomized Rat Model by Inhibiting Carbonic Anhydrase 2 Activity
Valsartan attenuates LPS-induced ALI by modulating NF-B and MAPK pathways - PMC
Journal
Frontiers in pharmacology
The effects of fresh Gastrodia elata Blume on the cognitive deficits induced by chronic restraint stress - PMC
Journal
Frontiers in pharmacology
Fresh Gastrodia elata Blume alleviates simulated weightlessness-induced cognitive impairment by regulating inflammatory and apoptosis-related pathways - PMC
Journal
Frontiers in pharmacology
Protective effects of ginsenosides Rg1 and Rb1 against cognitive impairment induced by simulated microgravity in rats - PMC
Journal
Frontiers in pharmacology
miRNA-874-3p inhibits the migration, invasion and proliferation of breast cancer cells by targeting VDAC1 - PMC
SHMT2 promotes tumor growth through VEGF and MAPK signaling pathway in breast cancer - PMC
Journal
American journal of cancer research
ZNF395 facilitates macrophage polarization and impacts the prognosis of glioma - PMC
Journal
American journal of cancer research
Modification-Specific Proteomic Analysis Reveals Cysteine S-Nitrosylation Mediated the Effect of Preslaughter Transport Stress on Pork Quality Development
Journal
Journal of agricultural and food chemistry
Effect of Pre-Slaughter Transport Stress on Protein S-Nitrosylation Levels of Pork during Postmortem Aging
Journal
Journal of agricultural and food chemistry
Quantitative Comparison of Presenilin Protein Expression Reveals Greater Activity of PS2-gamma-Secretase.
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Mice harboring a R133L heterozygous mutation in LMNA exhibited ectopic lipid accumulation, aging, and mitochondrial dysfunction in adipose tissue
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Characterization of Ictalurid herpesvirus 1 Glycoprotein ORF59 and Its Potential Role on Virus Entry into the Host Cells
Species
Ictalurus punctatus
Comprehensive Analysis of 5-Methylcytosine (m 5 C) Regulators and the Immune Microenvironment in Pancreatic Adenocarcinoma to Aid Immunotherapy
Journal
Frontiers in oncology
miRNA transcriptomics analysis shows miR-483-5p and miR-503-5p targeted miRNA in extracellular vesicles from severe acute pancreatitis-associated lung injury
Journal
International immunopharmacology
Inhibitory effect of daphnetin on the C48/80-induced pseudo-allergic reaction
Journal
International immunopharmacology
Gliclazide Ameliorates Neuronal Injury by Attenuating Oxidative Stress in D-gal-Induced Senescent Cells and Aging Mice
Journal
Molecular neurobiology
Etomidate Improves the Antidepressant Effect of Electroconvulsive Therapy by Suppressing Hippocampal Neuronal Ferroptosis via Upregulating BDNF/Nrf2
Journal
Molecular neurobiology
SCFAs Ameliorate Chronic Postsurgical Pain–Related Cognition Dysfunction via the ACSS2-HDAC2 Axis in Rats
Journal
Molecular neurobiology
Ubiquitination of Ku70 by Parkin promotes apoptosis of lens epithelial cells
Species
Homo sapiens, Mus musculus
Circ0007042 alleviates intervertebral disc degeneration by adsorbing miR-369 to upregulate BMP2 and activate the PI3K/AKt pathway - PMC
Journal
Arthritis research & therapy
Silver nanoparticles induced hippocampal neuronal damage involved in mitophagy, mitochondrial biogenesis and synaptic degeneration
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Endogenous hydrogen sulfide counteracts polystyrene nanoplastics-induced mitochondrial apoptosis and excessive autophagy via regulating Nrf2 and PGC-1α signaling pathway in mouse spermatocyte-derived GC-2spd(ts) cells
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
A novel epitope tag from rabies virus has versatile in vitro applications
Journal
Applied microbiology and biotechnology
The age-related characteristics in bone microarchitecture, osteoclast distribution pattern, functional and transcriptomic alterations of BMSCs in mice
Journal
Mechanisms of ageing and development
Mesenchymal Stem Cells Resist Mechanical Confinement through the Activation of the Cortex during Cell Division
Journal
ACS Biomater Sci Eng
BAY61?3606 attenuates neuroinflammation and neurofunctional damage by inhibiting microglial Mincle/Syk signaling response after traumatic brain injury
Design, synthesis and evaluation of EZH2-based PROTACs targeting PRC2 complex in lymphoma
Journal
Bioorganic chemistry
Knockdown of endogenous RNF4 exacerbates ischaemia‐induced cardiomyocyte apoptosis in mice
Synergistic effect of PARP inhibitor and BRD4 inhibitor in multiple models of ovarian cancer - PMC
Journal
Journal of cellular and molecular medicine
Species
Homo sapiens, Mus musculus
The role of PKN1 in glioma pathogenesis and the antiglioma effect of raloxifene targeting PKN1
Journal
Journal of cellular and molecular medicine
A pancancer analysis of the oncogenic role of ZNRF2 in human tumours
Journal
Journal of cellular and molecular medicine
Activation of adenosine A3 receptor attenuates progression of osteoarthritis through inhibiting the NLRP3/caspase-1/GSDMD induced signalling - PMC
Journal
Journal of cellular and molecular medicine
Cytochrome P450 enzymes mediated by DNA methylation is involved in deoxynivalenol-induced hepatoxicity in piglets
Journal
Animal nutrition (Zhongguo xu mu shou yi xue hui)
Copper overload induces apoptosis and impaired proliferation of T cell in zebrafish
Journal
Aquatic toxicology (Amsterdam, Netherlands)
Urantide alleviates the symptoms of atherosclerotic rats in vivo and in vitro models through the JAK2/STAT3 signaling pathway
Pinocembrin attenuates susceptibility to atrial fibrillation in rats with pulmonary arterial hypertension
Journal
European journal of pharmacology
Kinsenoside mitigates myocardial ischemia/reperfusion-induced ferroptosis via activation of the Akt/Nrf2/HO-1 pathway
Journal
European journal of pharmacology
Species
Mus musculus, Rattus norvegicus
LOXL2 small molecule inhibitor restrains malignant transformation of cervical cancer cells by repressing LOXL2 -induced epithelial-mesenchymal transition (EMT)
Journal
Cell cycle (Georgetown, Tex.)
Investigation on the Pathological Mechanism of Frequent Exacerbators With Chronic Obstructive Pulmonary Disease Based on the Characteristics of Respiratory Flora
Journal
Frontiers in medicine
Mechanism of apoptosis activation by curcumin rescued mutant p53Y220C in human pancreatic cancer
Journal
Biochimica et biophysica acta. Molecular cell research
Injectable kaempferol-loaded fibrin glue regulates the metabolic balance and inhibits inflammation in intervertebral disc degeneration - PMC
Journal
Scientific reports
PNO1 promotes the progression of osteosarcoma via TGF- and YAP/TAZ pathway - PMC
Journal
Scientific reports
ALS/FTD-associated mutation in cyclin F inhibits ER-Golgi trafficking, inducing ER stress, ERAD and Golgi fragmentation - PMC
Journal
Scientific reports
Downregulation of the NLRP3/Caspse-1 Pathway Ameliorates Ketamine-Induced Liver Injury and Inflammation in Developing Rats
Journal
Molecules (Basel, Switzerland)
Phenolic Compounds from Mori Cortex Ameliorate Sodium Oleate-Induced Epithelial-Mesenchymal Transition and Fibrosis in NRK-52e Cells through CD36
Molecular Cloning, Expression and Macrophage Activation of an Immunoregulatory Protein from Cordyceps militaris
Species
Cordyceps militaris
Intravitreal Injection of PACAP Attenuates Acute Ocular Hypertension-Induced Retinal Injury Via Anti-Apoptosis and Anti-Inflammation in Mice
Journal
Investigative ophthalmology & visual science
Neuroprotection of SRT2104 in Murine Ischemia/Reperfusion Injury Through the Enhancement of Sirt1-Mediated Deacetylation - PMC
Journal
Investigative ophthalmology & visual science
A Novel Bromophenol Compound from Leathesia nana Inhibits Breast Cancer in a Direct Tumor Killing and Immunotherapy Manner - PMC
Journal
Molecules (Basel, Switzerland)
Cepharanthine Exerts Antioxidant and Anti-Inflammatory Effects in Lipopolysaccharide (LPS)-Induced Macrophages and DSS-Induced Colitis Mice - PMC
Journal
Molecules (Basel, Switzerland)
Suppressing circIDE/miR-19b-3p/RBMS1 axis exhibits promoting-tumour activity through upregulating GPX4 to diminish ferroptosis in hepatocellular carcinoma - PMC
Rev-erb attenuates diabetic myocardial injury through regulation of ferroptosis
Journal
Cellular signalling
Knockdown of SQLE promotes CD8+ T cell infiltration in the tumor microenvironment
Journal
Cellular signalling
Maackiain suppresses the development of cervical cancer via AMPK priming autophagy
Journal
The Journal of pharmacy and pharmacology
Jie Geng Tang reverses cisplatin resistance through the Nrf2 pathway in lung cancer
Journal
The Journal of pharmacy and pharmacology
Receptor-interacting protein kinase 1 (RIPK1) regulates cervical cancer cells via NF-BTNF- pathway: An in vitro study
Journal
Translational oncology
TFRC-RNA interactions show the regulation of gene expression and alternative splicing associated with IgAN in human renal tubule mesangial cells - PMC
Journal
Frontiers in genetics
ENO2 as a Biomarker Regulating Energy Metabolism to Promote Tumor Progression in Clear Cell Renal Cell Carcinoma - PMC
APOL1 Induces Pyroptosis of Fibroblasts Through NLRP3/Caspase-1/GSDMD Signaling Pathway in Ulcerative Colitis - PMC
Journal
Journal of inflammation research
Impact of AADAC gene expression on prognosis in patients with Borrmann type III advanced gastric cancer - PMC
LAP3 contributes to IFN-γ-induced arginine depletion and malignant transformation of bovine mammary epithelial cells - PMC
Species
Rattus norvegicus,Bos taurus
Integrated analysis of miRNAs and mRNA profiling reveals the potential roles of miRNAs in sheep hair follicle development - PMC
Inhibitory Effect of Jinwujiangu Prescription on Peripheral Blood Osteoclasts in Patients with Rheumatoid Arthritis and the Relevant Molecular Mechanism - PMC
Journal
Mediators of inflammation
Mir-454-3p induced WTX deficiency promotes hepatocellular carcinoma progressions through regulating TGF-β signaling pathway
Vav1dependent Rac1 activation mediates hypoxiainduced gemcitabine resistance in pancreatic ductal adenocarcinoma cells through upregulation of HIF1
Journal
Cell biology international
Resveratrol protects against doxorubicin-induced cardiotoxicity by attenuating ferroptosis through modulating the MAPK signaling pathway
Journal
Toxicology and applied pharmacology
Species
Mus musculus,Rattus norvegicus
Long Noncoding RNA ADAMTS9-AS2 Inhibits the Proliferation, Migration, and Invasion in Bladder Tumor Cells
STAT2‐induced linc02231 promotes tumorigenesis and angiogenesis through modulation of hnRNPA1/ANGPTL4 in colorectal cancer
Journal
The journal of gene medicine
miR-143 Targeting CUX1 to Regulate Proliferation of Dermal Papilla Cells in Hu Sheep
p300-Catalyzed Lysine Crotonylation Promotes the Proliferation, Invasion, and Migration of HeLa Cells via Heterogeneous Nuclear Ribonucleoprotein A1
Journal
Anal Cell Pathol (Amst)
A Novel 3-meta-Pyridine-1,2,4-oxadiazole Derivative of Glycyrrhetinic Acid as a Safe and Promising Candidate for Overcoming P-Glycoprotein-Mediated Multidrug Resistance in Tumor Cells - PMC
GNPNAT1 promotes the stemness of breast cancer and serves as a potential prognostic biomarker - PMC
Overexpressed lncRNA FTX promotes the cell viability, proliferation, migration and invasion of renal cell carcinoma via FTX/miR-4429/UBE2C axis - PMC
Species
Homo sapiens, Mus musculus
Tail-Approach-Based
Design and Synthesis of Coumarin-Monoterpenes
as Carbonic Anhydrase Inhibitors and Anticancer Agents - PMC
CDCA5 promotes the progression of breast cancer and serves as a potential prognostic biomarker
Hydroxysafflor yellow A inhibits the hyperactivation of rat platelets by regulating the miR-9a-5p/SRC axis
Journal
Archives of biochemistry and biophysics
Epigenetic programming of TBX2/CX43 mediates lower sperm quality in male offspring induced by prenatal dexamethasone exposure
Journal
Toxicological sciences : an official journal of the Society of Toxicology
TMT-based quantitative proteomic analysis unveils uterine fluid difference in hens producing normal and pimpled eggs - PMC
Peptide OA-VI12 restrains melanogenesis in B16 cells and C57B/6 mouse ear skin via the miR-122-5p/Mitf/Tyr axis
An exploration of the effect of Chinese herbal compound on the occurrence and development of large intestine cancer and intestinal flora - PMC
Inhibition of SIRT6 aggravates p53-mediated ferroptosis in acute lung injury in mice - PMC
High expression COL10A1 promotes breast cancer progression and predicts poor prognosis - PMC
The function of Piezo1 in hepatoblastoma metastasis and its potential transduction mechanism - PMC
Wedelolactone ameliorates Pseudomonas aeruginosa-induced inflammation and corneal injury by suppressing caspase-4/5/11/GSDMD-mediated non-canonical pyroptosis
Species
Homo sapiens,Rattus norvegicus
Osthole protects H9c2 cardiomyocytes against trastuzumab-induced damage by enhancing autophagy through the p38MAPK/mTOR signaling pathway
Journal
Toxicology in vitro : an international journal published in association with BIBRA
Bortezomib inhibits hepatocellular carcinoma via the Hippo‐YAP signaling pathway
Journal
Basic & clinical pharmacology & toxicology
SIRT6 ameliorates LPS-induced apoptosis and tight junction injury in ARDS through the ERK1/2 pathway and autophagy - PMC
Journal
International journal of medical sciences
The induction of ferroptosis in posthemorrhagic hydrocephalus
The potential pathogenic roles of S100A8/A9 and S100A12 in patients with MPO-ANCA-positive vasculitis - PMC
Ceramide Analog 5cc Overcomes TRAIL Resistance by Enhancing JNK Activation and Repressing XIAP Expression in Metastatic Colon Cancer Cells
VasH contributes to virulence of Aeromonas hydrophila and is necessary to the T6SS-mediated bactericidal effect
Journal
Frontiers in veterinary science
Species
Ctenopharyngodon idellus
Heparan sulfate is the attachment factor associated with channel catfish virus infection on host cells - PMC
Journal
Frontiers in veterinary science
Species
Ictalurus punctatus
Ferroptosis contributes to hemolytic hyperbilirubinemia-induced brain damage in vivo and in vitro - PMC
Journal
Molecular medicine reports
MicroRNA-320a suppresses tumor progression by targeting PBX3 in gastric cancer and is downregulated by DNA methylation.
Journal
World Journal of Gastrointestinal Oncology
MicroRNA-133b Inhibits nTumor Cell Proliferation, Migration and Invasion by Targeting SUMO1 in Endometrial Carcinoma
Journal
Technol Cancer Res Treat
Disulfiram Relieves Severe Acute Pancreatitis by Inhibiting GSDMDDependent NETs Formation
Journal
Journal of digestive diseases
Human cytomegalovirus IE2 may impair the cognitive ability of the hippocampus through the GluNRs/CaMKIIα/CREB signaling pathway in the Rosa26-LSL-IE2/Cre mouse
Andrographolide attenuates choroidal neovascularization by inhibiting the HIF-1伪/VEGF signaling pathway
Journal
Biochem Biophys Res Commun
Regulatory role of RGMb in lung injury promoted by the combination of carbon ion irradiation and anti-PD-1 antibody through Erk1/2 and p38 MAPK pathways
Journal
Biochemical and biophysical research communications
Copper-containing titanium alloys promote the coupling of osteogenesis and angiogenesis by releasing copper ions
Journal
Biochemical and biophysical research communications
Aberrant NAD synthetic flux in podocytes under diabetic conditions and effects of indoleamine 2, 3-dioxygenase on promoting de novo NAD synthesis
Journal
Biochemical and biophysical research communications
MiR-4521 affects the propagation of Cryptosporidium parvum in HCT-8 cells through targeting foxm1 by regulating cell apoptosis
Autophagy inhibition mediated by trillin promotes apoptosis in hepatocellular carcinoma cells via activation of mTOR/STAT3 signaling
Journal
Naunyn-Schmiedeberg's archives of pharmacology
Liquiritin reduces ferroptosis in doxorubicin-induced cardiotoxicity through targeting SLC7A11/GPX4 pathway
Journal
Naunyn-Schmiedeberg's archives of pharmacology
MicroRNA-100 inhibits breast cancer cell proliferation, invasion and migration by targeting FOXA1
Silencing of CPNE1-TRAF2 Axis Restrains the Development of Pancreatic Cancer
Journal
Frontiers in bioscience (Landmark edition)
miR-5590-3p inhibits the proliferation and metastasis of renal cancer cells by targeting ROCK2 to inhibit proliferation, migration and invasion - PMC
USF1 modulates transcription and cellular functions by regulating multiple transcription factors in Huh7 cells - PMC
Sphincter of Oddi Dysfunction Induces Gallstone by Inhibiting the Expression of ABCB11 via PKC-
Journal
Applied biochemistry and biotechnology
Profile of the bile acid FXR-FGF15 pathway in the glucolipid metabolism disorder of diabetic mice suffering from chronic stress - PMC
The role of targeted regulation of COX11 by miR-10a-3p in the development and progression of paediatric mycoplasma pneumoniae pneumonia
Rectangular method: a modified technique for sampling the ischemic border zone in a rat model of transient middle cerebral artery occlusion - PMC
Journal
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
Proteomic analysis of neonatal mouse hearts shows PKA functions as a cardiomyocyte replication regulator - PMC
Inhibition of perilipin 2 attenuates cerebral ischemia/reperfusion injury by blocking NLRP3 inflammasome activation both in vivo and in vitro
Journal
In vitro cellular & developmental biology. Animal
Combination effect of Chinese kidney-tonifying granules and platelet-rich plasma gels on enhancing bone healing in rat models with femur defects - PMC
Journal
Journal of orthopaedic surgery and research
Dysregulated RUNX1 Predicts Poor Prognosis by Mediating Epithelialmesenchymal Transition in Cervical Cancer
Journal
Current medical science
Manganese deficiency induces avian tibial dyschondroplasia by inhibiting chondrocyte proliferation and differentiation
Effects of low level laser on periodontal tissue remodeling in hPDLCs under tensile stress - PMC
Journal
Lasers in medical science
miR-100-5p is upregulated in multiple myeloma and involves in the pathogenesis of multiple myeloma through targeting MTMR3
Journal
Hematology (Amsterdam, Netherlands)
Puerarin protects against myocardial ischemia/reperfusion injury by inhibiting ferroptosis
Journal
Biological & pharmaceutical bulletin
Species
Mus musculus,Rattus norvegicus
EGR2 is a hub-gene in myocardial infarction and aggravates inflammation and apoptosis in hypoxia-induced cardiomyocytes - PMC
Journal
BMC cardiovascular disorders
Safflor yellow A protects vascular endothelial cells from ox-LDL-mediated damage
Journal
J Recept Signal Transduct Res
CELF1 promotes matrix metalloproteinases gene expression at transcriptional level in lens epithelial cells
miR-195-3p/BDNF axis regulates hypoxic injury by targeting P-ERK1/2 expression - PMC
Echinacoside exerts its protective effects in a type 2 diabetes mellitus injury model via the AKT pathway
Journal
Journal of Asian natural products research
Circular RNA protein tyrosine kinase 2 aggravates pyroptosis and inflammation in septic lung tissue by promoting microRNA-766/eukaryotic initiation factor 5A axis …
Journal
Acta cirurgica brasileira
The Krppel-like factor 6 represses proliferation and invasion of cutaneous malignant melanoma
Journal
Polish journal of pathology : official journal of the Polish Society of Pathologists
Programmed Cell Death Protein 2-like Promotes Inflammation and Oxidative Stress in Vascular Endothelial Cells
Journal
ACS pharmacology & translational science
Metabolomics Analysis Reveals Alterations in Cochlear Metabolic Profiling in Mice with Noise-Induced Hearing Loss
Journal
BioMed research international
Type I interferon/STAT1 signaling regulates UBE2M-mediated antiviral innate immunity in a negative feedback manner
Nodal promotes colorectal cancer survival and metastasis through regulating SCD1-mediated ferroptosis resistance - PMC
Journal
Cell death & disease
Single-cell sequencing reveals the optimal time window for anti-inflammatory treatment in spinal cord injury
Force-Induced Nitric Oxide Promotes Osteogenic Activity during Orthodontic Tooth Movement in Mice - PMC
Journal
Stem cells international
Enhanced nuclear translation is associated with proliferation and progression across multiple cancers - PMC
Establishment of two oxaliplatin-resistant gallbladder cancer cell lines and comprehensive analysis of dysregulated genes - PMC
Journal
Open medicine (Warsaw, Poland)
LncRNA SNHG1 upregulates FANCD2 and G6PD to suppress ferroptosis by sponging miR-199a-5p/3p in hepatocellular carcinoma
Journal
Drug discoveries & therapeutics
The m6A modification-mediated OGDHL exerts a tumor suppressor role in ccRCC by downregulating FASN to inhibit lipid synthesis and ERK signaling - PMC
Journal
Cell death & disease
ZHX2 deficiency enriches hybrid MET cells through regulating E-cadherin expression - PMC
Journal
Cell death & disease
Scutellarin Loaded on Ultradeformable Nanoliposome Scutellarin EDTMP (S-UNL-E) Promotes Osteogenesis in Osteoporotic Rats - PMC
Journal
Stem cells international
Multi-omics characterization of silent and productive HPV integration in cervical cancer
Species
Oryctolagus cuniculus
Histone methyltransferase Dot1L recruits O-GlcNAc transferase to target chromatin sites to regulate histone O-GlcNAcylation - PMC
Journal
The Journal of biological chemistry
Inhibition of SIRT2 promotes APP acetylation and ameliorates cognitive impairment in APP/PS1 transgenic mice