TRIM21 suppresses CHK1 activation by preferentially targeting CLASPIN for K63-linked ubiquitination
Journal
Nucleic acids research
The DNA dioxygenase Tet1 regulates H3K27 modification and embryonic stem cell biology independent of its catalytic activity
Journal
Nucleic acids research
PARP1 and CHK1 coordinate PLK1 enzymatic activity during the DNA damage response to promote homologous recombination-mediated repair
Zfp217 mediates m6A mRNA methylation to orchestrate transcriptional and post-transcriptional regulation to promote adipogenic differentiation.
Journal
Nucleic acids research
CD36 inhibits -catenin/c-myc-mediated glycolysis through ubiquitination of GPC4 to repress colorectal tumorigenesis.
Journal
Nature communications
CD36 inhibits -catenin/c-myc-mediated glycolysis through ubiquitination of GPC4 to repress colorectal tumorigenesis
Journal
Nature communications
Species
Homo sapiens, Mus musculus
Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver
TRADES: Targeted RNA Demethylation by SunTag System
Solid fuel derived PM2. 5 induced oxidative stress and according cytotoxicity in A549 cells: The evidence and potential neutralization by green tea
Journal
Environment international
Maternal Exposure to Di-n-butyl Phthalate Promotes the Formation of Testicular Tight Junctions through Downregulation of NF-κB/COX-2/PGE2/MMP-2 in Mouse Offspring
Journal
Environmental Science & Technology
Ultra-small polydopamine nanomedicine-enabled antioxidation against senescence - PMC
Journal
Materials today. Bio
Alleviation of Toxicity Caused by Overactivation of Pparα through Pparα-Inducible miR-181a2
Journal
MOLECULAR THERAPY-NUCLEIC ACIDS
PI4KB on Inclusion Bodies Formed by ER Membrane Remodeling Facilitates Replication of Human Parainfluenza Virus Type 3
Comprehensive proteomic and phosphoproteomic reveal that Microcystin-LR contributed to the malignant progression of gastric cancer by estrogenic potency
Journal
Environmental pollution (Barking, Essex : 1987)
SUMOylated IL-33 in the nucleus stabilizes the transcription factor IRF1 in hepatocellular carcinoma cells to promote immune escape
XPO1 intensifies sorafenib resistance by stabilizing acetylation of NPM1 and enhancing epithelial-mesenchymal transition in hepatocellular carcinoma
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Patchouli Alcohol Inhibits D-Gal Induced Oxidative Stress and Ameliorates the Quality of Aging Cartilage via Activating the Nrf2/HO-1 Pathway in Mice - PMC
Journal
Oxidative medicine and cellular longevity
Electroacupuncture pretreatment preserves telomerase reverse transcriptase function and alleviates postoperative cognitive dysfunction by suppressing oxidative
Journal
CNS neuroscience & therapeutics
Role of diets and exercise in ameliorating obesity-related hepatic steatosis: Insights at the microRNA-dependent thyroid hormone synthesis and action
Consumption of Saturated Fatty Acids‐Rich Lard Benefits Recovery of Experimental Arthritis by Activating PPAR‐γ
Journal
Molecular nutrition & food research
The C-ETS2-TFEB Axis Promotes Neuron Survival under Oxidative Stress by Regulating Lysosome Activity
Journal
Oxidative Medicine And Cellular Longevity
Casticin prevents DSS induced ulcerative colitis in mice through inhibitions of NF‐κB pathway and ROS signaling
Journal
Phytotherapy Research : PTR
Replacing dietary sodium selenite with biogenic selenium nanoparticles improves the growth performance and gut health of early-weaned piglets
TTB Protects Astrocytes Against Oxygen-Glucose Deprivation/Reoxygenation-Induced Injury via Activation of Nrf2/HO-1 Signaling Pathway.
Journal
Frontiers in Pharmacology
The Mitochondrial-Derived Peptide (MOTS-c) Interacted with Nrf2 to Defend the Antioxidant System to Protect Dopaminergic Neurons Against Rotenone Exposure
Journal
Molecular neurobiology
Phosphorylation of MITF by AKT affects its downstream targets and causes TP53-dependent cell senescence
Journal
The international journal of biochemistry & cell biology
Isorhynchophylline ameliorates the progression of osteoarthritis by inhibiting the NF-B pathway
Journal
European journal of pharmacology
Zanthoxylum bungeanum amides ameliorates nonalcoholic fatty liver via regulating gut microbiota and activating AMPK/Nrf2 signaling
Journal
Journal of ethnopharmacology
Interpretation of the anti-influenza active ingredients and potential mechanisms of Ge Gen Decoction based on spectrum-effect relationships and network analysis
Journal
Journal of ethnopharmacology
Kinsenoside mitigates myocardial ischemia/reperfusion-induced ferroptosis via activation of the Akt/Nrf2/HO-1 pathway
Journal
European journal of pharmacology
Species
Mus musculus, Rattus norvegicus
Shiwei Qingwen decoction regulates TLR4/NF-κB signaling pathway and NLRP3 inflammasome to reduce inflammatory response in lipopolysaccharide-induced …
Journal
Journal of ethnopharmacology
Oral administration of ellagic acid mitigates perioperative neurocognitive disorders, hippocampal oxidative stress, and neuroinflammation in aged mice by restoring IGF-1 signaling - PMC
Journal
Scientific reports
Ethanol Extract of Rosa laevigata Michx. Fruit Inhibits Inflammatory Responses through NF-κB/MAPK Signaling Pathways via AMPK Activation in RAW 264.7 Macrophages - PMC
Journal
Molecules (Basel, Switzerland)
Mas-related G protein-coupled receptor D participates in inflammatory pain by promoting NF-κB activation through interaction with TAK1 and IKK complex
Fam83h mutation causes mandible underdevelopment via CK1α-mediated Wnt/β-catenin signaling in male C57/BL6J mice
Female-specific activation of pregnane X receptor mediates sex difference in fetal hepatotoxicity by prenatal monocrotaline exposure
Journal
Toxicol Appl Pharmacol
Methylcobalamin Protects Melanocytes from H 2 O 2-Induced Oxidative Stress by Activating the Nrf2/HO-1 Pathway
Journal
Drug Des Devel Ther
Translocator Protein alleviates allodynia and improves Schwann cells function against diabetic peripheral neuropathy via activation of the Nrf2‐dependent antioxidant …
Journal
Diabetic medicine : a journal of the British Diabetic Association
Effects of manganese on microglia M1/M2 polarization and SIRT1-mediated transcription of STAT3-dependent genes in mouse
Tanshinone IIA-regulation of IL-6 antagonizes PM 2 .5 -induced proliferation of human bronchial epithelial cells via a STAT3/miR-21 reciprocal loop
Journal
Environmental toxicology
Myocardial infarction-induced anxiety-like behavior is associated with epigenetic alterations in the hippocampus of rat
RAGE/NF-κB pathway mediates hypoxia-induced insulin resistance in 3T3-L1 adipocytes
Journal
Biochemical and Biophysical Research Communications
Network pharmacology and experimental validation identify the potential mechanism of sophocarpine for COVID-19
Journal
Journal of medical microbiology
Suffrutines A and B Inhibit the Expression of Inflammatory Mediators in LPS-Induced RAW264. 7 Cells by Suppressing the NF-κB Signaling Pathway
Ophiopogonin D attenuates PM2. 5‑induced inflammation via suppressing the AMPK/NF‑κB pathway in mouse pulmonary epithelial cells
Glycoprotein non-metastaticmelanoma protein B promotes glioma motility and angiogenesis through the Wnt/β-catenin signaling pathway.
Journal
Experimental Biology and Medicine
The mechanism of acentrosomal spindle assembly in human oocytes