Smad3 methylation by EZH2 promotes its activation and tumor metastasis
Journal
The Journal of clinical investigation
The proteasome component PSMD14 drives myelomagenesis through a histone deubiquitinase activity
Breast cancer cell-derived extracellular vesicles promote CD8+T cell exhaustion via TGF- type II receptor signaling - PMC
Journal
Nature communications
Tsp-1+ microglia attenuate retinal neovascularization by maintaining the expression of Smad3 in endothelial cells through exosomes with decreased miR-27a-5p - PMC
Inhibition of HIPK2 protects stress-induced pathological cardiac remodeling - PMC
Epigenetic Modulation of Class-Switch DNA Recombination to IgA by miR-146a Through Downregulation of Smad2, Smad3 and Smad4
PRMT5 methylating Smad4 activates TGF- signaling and promotes colorectal cancer metastasis
Biphasic regulation of osteoblast development via the ERK MAPK-mTOR pathway - PMC
Species
Homo sapiens,Mus musculus
Paris polyphylla ethanol extract and polyphyllin I ameliorate adenomyosis by inhibiting epithelialmesenchymal transition
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
miR-135a Suppresses Granulosa Cell Growth by Targeting Tgfbr1 and Ccnd2 during Folliculogenesis in Mice
Follistatin Is a Novel Chemoattractant for Migration and Invasion of Placental Trophoblasts of Mice - PMC
Losartan ameliorates renal interstitial fibrosis through metabolic pathway and Smurfs-TGF-/Smad
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Shenkang Injection for Treating Renal Fibrosis-Metabonomics and Regulation of E3 Ubiquitin Ligase Smurfs on TGF-/Smads Signal Transduction - PMC
Journal
Frontiers in pharmacology
Shenkang Injection for Treating Renal Fibrosis-Metabonomics and Regulation of E3 Ubiquitin Ligase Smurfs on TGF-/Smads Signal Transduction - PMC
Journal
Frontiers in pharmacology
USF1 transcriptionally activates USP14 to drive atherosclerosis by promoting EndMT through NLRC5/Smad2/3 axis - PMC
Journal
Molecular medicine (Cambridge, Mass.)
Species
Homo sapiens,Mus musculus
Prenatal EGCG exposure-induced heart mass reduction in adult male mice and underlying mechanisms
Respiratory exposure to graphene quantum dots causes fibrotic effects on lung, liver and kidney of mice
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Baihe Wuyao decoction ameliorates CCl4-induced chronic liver injury and liver fibrosis in mice through blocking TGF-β1/Smad2/3 signaling, anti-inflammation and anti-oxidation effects
Bletilla striata polysaccharide attenuated the progression of pulmonary fibrosis by inhibiting TGF-1/Smad signaling pathway
Journal
Journal of ethnopharmacology
Activin A/ACVR2A axis inhibits epithelialtomesenchymal transition in colon cancer by activating SMAD2
Journal
Molecular carcinogenesis
Acute and long-term effects of cannabinoids on hypertension and kidney injury
Journal
Scientific reports
PNO1 promotes the progression of osteosarcoma via TGF- and YAP/TAZ pathway - PMC
Journal
Scientific reports
Inhibitory effects of Schisandrin C on collagen behavior in pulmonary fibrosis - PMC
Journal
Scientific reports
miRNA-660-3p inhibits malignancy in glioblastoma via negative regulation of APOC1-TGF2 signaling pathway
Journal
Cancer biology & therapy
miRNA-660-3p inhibits malignancy in glioblastoma via negative regulation of APOC1-TGF2 signaling pathway
Journal
Cancer biology & therapy
IRAK-M Regulates Proliferative and Invasive Phenotypes of Lung Fibroblasts
Computational Systems Pharmacology, Molecular Docking and Experiments Reveal the Protective Mechanism of Li-Da-Qian Mixture in the Treatment of Glomerulonephritis
Journal
Journal of inflammation research
Mir-454-3p induced WTX deficiency promotes hepatocellular carcinoma progressions through regulating TGF-β signaling pathway
Improvement of vaginal probiotics Lactobacillus crispatus on intrauterine adhesion in mice model and in clinical practice - PMC
Study on effects and relevant mechanisms of Mudan granules on renal fibrosis in streptozotocin-induced diabetes rats
Loss of Farnesoid X receptor (FXR) accelerates dysregulated glucose and renal injury in db/db mice - PMC
Rivaroxaban, a direct inhibitor of coagulation factor Xa, attenuates adverse cardiac remodeling in rats by regulating the PAR-2 and TGF-1 signaling pathways - PMC
Muscone inhibits angiotensin II-induced cardiac hypertrophy through the STAT3, MAPK and TGF-/SMAD signaling pathways - PMC
Journal
Molecular biology reports
Hesperetin mitigates bile duct ligation-induced liver fibrosis by inhibiting extracellular matrix and cell apoptosis via the TGF-β1/Smad pathway
Journal
Current molecular medicine
Suppression of ADAM8 attenuates angiotensin II-induced cardiac fibrosis and endothelial-mesenchymal transition via inhibiting TGF-β1/Smad2/Smad3 pathways
Journal
Experimental animals