Cysteine-Based Redox-Responsive Nanoparticles for Fibroblast-Targeted Drug Delivery in the Treatment of Myocardial Infarction
Yin Yang 1Induced Long Noncoding RNA DUXAP9 Drives the Progression of Oral Squamous Cell Carcinoma by Blocking CDK1Mediated EZH2 Degradation
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
A Single-Cell Transcriptomic Atlas of Human Skin Aging
Journal
Developmental Cell
Ferroptosis is critical for phthalates driving the blood-testis barrier dysfunction via targeting transferrin receptor - PMC
The effects of endosulfan on cell migration and invasion in prostate cancer cells via the KCNQ1OT1/miR-137-3p/PTP4A3 axis
Journal
The Science of the total environment
Distinguished biomimetic dECM system facilitates early detection of metastatic breast cancer cells
Journal
Bioengineering & translational medicine
WD repeat protein 54-mediator of ErbB2-driven cell motility 1 axis promotes bladder cancer tumorigenesis and metastasis and impairs chemosensitivity
Single-cell RNA sequencing reveals the immune microenvironment and signaling networks in cystitis glandularis - PMC
Journal
Frontiers in immunology
SILAC proteomics based on 3D cell spheroids unveils the role of RAC2 in regulating the crosstalk between triple-negative breast cancer cells and tumor-associated
Journal
International journal of biological macromolecules
LTB4R Promotes the Occurrence and Progression of Clear Cell Renal Cell Carcinoma (ccRCC) by Regulating the AKT/mTOR Signaling Pathway - PMC
HOCI Probe CPP Induces the Differentiation of Human Dermal Fibroblasts into Vascular Endothelial Cells through PHD2/HIF-1α/HEY1 Signaling Pathway - PMC
Ovatodiolide inhibits SARS-CoV-2 replication and ameliorates pulmonary fibrosis through suppression of the TGF-/TRs signaling pathway - PMC
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Species
Homo sapiens, Chlorocebus aethiops
The Interaction of Apelin and FGFR1 Ameliorated the Kidney Fibrosis through Suppression of TGFβ-Induced Endothelial-to-Mesenchymal Transition - PMC
Journal
Oxidative medicine and cellular longevity
miR-409-3p Regulated by GATA2 Promotes Cardiac Fibrosis through Targeting Gpd1 - PMC
Journal
Oxidative medicine and cellular longevity
Histone deacetylase 3 deletion in alveolar type 2 epithelial cells prevents bleomycin-induced pulmonary fibrosis - PMC
Journal
Clinical epigenetics
Long noncoding RNA LINC00857 promotes pancreatic cancer proliferation and metastasis by regulating the miR-130b/RHOA axis
Journal
Cell death discovery
Role of PATJ in Stroke Prognosis by modulating Endothelial to Mesenchymal Transition through the Hippo/Notch/PI3K Axis.
Journal
Cell death discovery
Ginsenoside Rg3 suppresses vasculogenic mimicry by impairing DVL3-maintained stemness via PAAD cell-derived exosomal miR-204 in pancreatic
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Brusatol Suppresses the Tumor Growth and Metastasis of Colorectal Cancer via Upregulating ARRDC4 Expression through Modulating PI3K/YAP1/TAZ Pathway
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Taraxasterol Inhibits Tumor Growth by Inducing Apoptosis and Modulating the Tumor Microenvironment in Non-Small Cell Lung Cancer - PMC
Species
Homo sapiens, Mus musculus
CCL21/CCR7 interaction promotes EMT and enhances the stemness of OSCC via a JAK2/STAT3 signaling pathway
Journal
Journal of cellular physiology
Local radiotherapy for murine breast cancer increases risk of metastasis by promoting the recruitment of M-MDSCs in lung - PMC
Journal
Cancer cell international
The humanin analogue (HNG) alleviates intrauterine adhesions by inhibiting endometrial epithelial cells ferroptosis: a rat model-based study
Journal
Human reproduction (Oxford, England)
Carvacrol preserves antioxidant status and attenuates kidney fibrosis via modulation of the TGF-1/Smad signaling and inflammation
Fascaplysin Induces Apoptosis and Ferroptosis, and Enhances Anti-PD-1 Immunotherapy in Non-Small Cell Lung Cancer (NSCLC) by Promoting PD-L1 Expression - PMC
Journal
International journal of molecular sciences
Species
Homo sapiens, Mus musculus
Prostaglandin F2α Regulates Adipogenesis by Modulating Extracellular Signal-Regulated Kinase Signaling in Graves Ophthalmopathy - PMC
Journal
International journal of molecular sciences
Layered Double Hydroxides-Loaded Sorafenib Inhibit Hepatic Stellate Cells Proliferation and Activation In Vitro and Reduce Fibrosis In Vivo
- PMC
Journal
Frontiers in bioengineering and biotechnology
Identification of linderalactone as a natural inhibitor of SHP2 to ameliorate CCl4-induced liver fibrosis - PMC
Journal
Frontiers in pharmacology
AIM2 inflammasome activation benefits the therapeutic effect of BCG in bladder carcinoma - PMC
Journal
Frontiers in pharmacology
LncRNA HLA-F-AS1 promotes colorectal cancer metastasis by inducing PFN1 in colorectal cancer-derived extracellular vesicles and mediating macrophage polarization
KLK4 promotes proliferation, migration, invasion, and pro-angiogenesis of endometrial stromal cells via regulation of regulation of BDNF production in endometriosis
Journal
The American journal of pathology
Establishment and characterization of an immortalized epithelial cell line from human gallbladder - PMC
Journal
Frontiers in oncology
Transcranial Direct Current Stimulation Alleviates Neurovascular Unit Dysfunction in Mice With Preclinical Alzheimer's Disease
Journal
Frontiers in aging neuroscience
USF1 transcriptionally activates USP14 to drive atherosclerosis by promoting EndMT through NLRC5/Smad2/3 axis - PMC
Journal
Molecular medicine (Cambridge, Mass.)
Species
Homo sapiens,Mus musculus
KIF18B as a regulator in tumor microenvironment accelerates tumor progression and triggers poor outcome in hepatocellular carcinoma
Journal
Int J Biochem Cell Biol
LncRNA GAS5 regulates migration and epithelial-to-mesenchymal transition in lens epithelial cells via the miR-204-3p/TGFBR1 axis
Brusatol enhances MEF2A expression to inhibit RCC progression through the Wnt signalling pathway in renal cell carcinoma
Journal
Journal of cellular and molecular medicine
The Core-Targeted RRM2 Gene of Berberine Hydrochloride Promotes Breast Cancer Cell Migration and Invasion via the Epithelial-Mesenchymal Transition - PMC
Journal
Pharmaceuticals (Basel, Switzerland)
Bletilla striata polysaccharide attenuated the progression of pulmonary fibrosis by inhibiting TGF-1/Smad signaling pathway
Journal
Journal of ethnopharmacology
Oct4 promoted proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in colon cancer cells by activating the SCF/c-Kit signaling pathway
Journal
Cell cycle (Georgetown, Tex.)
Assessment of doxorubicin toxicity using human cardiac organoids: A novel model for evaluating drug cardiotoxicity
Journal
Chemico-biological interactions
I-8, a novel inhibitor of mutant IDH1, inhibits cancer progression in vitro and in vivo
Journal
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Phase separation of α-crystallin-GFP protein and its implication in cataract disease - PMC
Journal
Scientific reports
DUSP2 affects bladder cancer prognosis by down-regulating MEK/ERK and P38 MAPK signaling pathways through PTPN7
Journal
Cellular signalling
Application
WB, IHC, IF, IP
Downregulation of a potential therapeutic target NPAS2, regulated by p53, alleviates pulmonary fibrosis by inhibiting epithelial-mesenchymal transition via
Journal
Cellular signalling
The mRNA stability of NCAPG2, a novel contributor to breast invasive carcinoma, is enhanced by the RNA-binding protein PCBP2
Journal
Cellular signalling
The Apelin-APJ axis alleviates LPS-induced pulmonary fibrosis and endothelial mesenchymal transformation in mice by promoting Angiotensin-Converting Enzyme 2
Journal
Cellular signalling
DHCR7 promotes tumorigenesis via activating PI3K/AKT/mTOR signalling pathway in bladder cancer
Journal
Cellular Signalling
miR-140-3p inhibits colorectal cancer progression and its liver metastasis by targeting BCL9 and BCL2
HHLA2 deficiency inhibits non‐small cell lung cancer progression and THP‐1 macrophage M2 polarization
RAB3D, upregulated by aryl hydrocarbon receptor (AhR), promotes the progression of prostate cancer by activating the PI3K/AKT signaling pathway
Journal
Cell biology international
Nucleoporin 93, a new substrate of the E3 ubiquitin protein ligase HECTD1, promotes esophageal squamous cell carcinoma progression
The prognostic marker elastin correlates with epithelial–mesenchymal transition and vimentin‐positive fibroblasts in gastric cancer
Journal
The journal of pathology. Clinical research
TRIM11 Promotes Proliferation, Migration, Invasion and EMT of Gastric Cancer by Activating β-Catenin Signaling
Network Pharmacology Analysis and Experimental Validation to Investigate the Mechanism of Total Flavonoids of Rhizoma Drynariae in Treating Rheumatoid Arthritis - PMC
Journal
Drug design, development and therapy
MDM2-mediated ubiquitination of LKB1 contributes to the development of diabetic cataract
Journal
Experimental cell research
Senescent Fibroblasts Generate a CAF Phenotype through the Stat3 Pathway - PMC
Layered Double
Hydroxide-Loaded miR-30a for the Treatment
of Breast Cancer In Vitro and In Vivo - PMC
ENO2 affects the EMT process of renal cell carcinoma and participates in the regulation of the immune microenvironment
miR‐450b promotes cell migration and invasion by inhibiting SERPINB2 in oral squamous cell carcinoma
Involvement of Ataxin-3 (ATXN3) in the malignant progression of pancreatic cancer via deubiquitinating HDAC6
Journal
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]
ALDH5A1 acts as a tumour promoter and has a prognostic impact in papillary thyroid carcinoma
Journal
Cell Biochem Funct
Colorectal cancer tumor cell-derived exosomal miR-203a-3p promotes CRC metastasis by targeting PTEN-induced macrophage polarization
SOX8 promotes tumor growth and metastasis through FZD6-dependent Wnt/-catenin signaling in colorectal carcinoma - PMC
Different expression patterns of inflammatory cytokines induced by lipopolysaccharides from Escherichia coli or Porphyromonas gingivalis in human dental pulp stem cells
SiO2 dust induces inflammation and pulmonary fibrosis in rat lungs through activation of ASMase/Ceramide pathway
Journal
Journal of applied toxicology : JAT
CPEB3, an RNA-Binding Protein, Modulates the Behavior of Endometriosis-Derived Stromal Cells via Regulating CXCL12
Journal
DNA and cell biology
LINC00982 Inhibits the Proliferation, Migration, and Invasion of Breast Cancer Cells Through the miR-765/DPF3 Axis
Journal
DNA and cell biology
Let-7d miRNA prevents TGF-β1-induced EMT and renal fibrogenesis through regulation of HMGA2 expression
Journal
Biochemical and biophysical research communications
CUX1 promotes epithelial-mesenchymal transition (EMT) in renal fibrosis of UUO model by targeting MMP7
Journal
Biochemical and biophysical research communications
Species
Homo sapiens, Mus musculus
Tryptanthrin Regulates Vascular Smooth Muscle Cell Phenotypic Switching in Atherosclerosis by AMP-Activated Protein Kinase/Acetyl-CoA Carboxylase Signaling Pathway
Journal
Journal of cardiovascular pharmacology
GREM1 is a potential biomarker for the progression and prognosis of bladder cancer - PMC
Journal
World journal of surgical oncology
Microcyst fluid promotes the migration and invasion of fibroblasts in the adventitial layer of alveolar echinococcosis
UHMK1 promotes lung adenocarcinoma oncogenesis by regulating the PI3K/AKT/mTOR signaling pathway
Arsenic Sulfide Inhibits Hepatocellular Carcinoma Metastasis by Suppressing the HIF-1/VEGF Pathway
Journal
Frontiers in bioscience (Landmark edition)
IGFBP3 inhibits angiotensin II‐induced aortic smooth muscle cell phenotypic switch and MMPs expression
Early growth response 2, a novel target of pelvic organ prolapse, is highly expressed in anterior vaginal wall tissues with pelvic organ prolapse
Journal
Histochemistry and cell biology
Krüppel-like factor 1 serves as a facilitator in gastric cancer progression via activating the Wnt/β-catenin pathway
Journal
Acta biochimica Polonica
MiR-133a-3p inhibits scar formation in scalded mice and suppresses the proliferation and migration of scar derived-fibroblasts by targeting CTGF
miR-100-5p is upregulated in multiple myeloma and involves in the pathogenesis of multiple myeloma through targeting MTMR3
Journal
Hematology (Amsterdam, Netherlands)
GLIS Family Zinc Finger 3 Promotes Triple-Negative Breast Cancer Progression by Inducing Cell Proliferation, Migration and Invasion, and Activating the NF
Journal
Biological & pharmaceutical bulletin
Polygonatum sibiricum Polysaccharide Inhibited Liver Cancer in a Simulated Tumor Microenvironment by Eliminating TLR4/STAT3 Pathway
Journal
Biological & pharmaceutical bulletin
KIF23 promotes triple negative breast cancer through activating epithelial-mesenchymal transition
Calycosin attenuates pulmonary fibrosis by the epithelial-mesenchymal transition repression upon inhibiting the AKT/GSK3β/β-catenin signaling pathway
Organoid-derived human retinal progenitor cells promote early dedifferentiation of Müller glia in Royal College of Surgeons rats - PMC
Journal
International journal of ophthalmology
Establishment of two oxaliplatin-resistant gallbladder cancer cell lines and comprehensive analysis of dysregulated genes - PMC
Journal
Open medicine (Warsaw, Poland)
Downregulation of RNA binding protein 47 predicts low survival in patients and promotes the development of renal cell malignancies through RNA stability modification - PMC
Journal
Molecular biomedicine
Identification of candidate biomarker EMP3 and its prognostic potential in clear cell renal cell carcinoma
Journal
Frontiers in bioscience (Landmark edition)