Oriented nanofibrous P(MMD-co-LA)/Deferoxamine nerve scaffold facilitates peripheral nerve regeneration by regulating macrophage phenotype and revascularization
A dopamine-precursor-based nanoprodrug for in-situ drug release and treatment of acute liver failure by inhibiting NLRP3 inflammasome and facilitating liver regeneration
In situ sequestration of endogenous PDGF-BB with an ECM-mimetic sponge for accelerated wound healing
An injectable and adaptable hydrogen sulfide delivery system for modulating neuroregenerative microenvironment - PMC
Artificial tumor microenvironment regulated by first hemorrhage for enhanced tumor targeting and then occlusion for synergistic bioactivation of hypoxia …
Journal
Acta pharmaceutica Sinica. B
Immune mechanisms shape the clonal landscape during early progression of prostate cancer
Journal
Developmental cell
USP15 promotes pulmonary vascular remodeling in pulmonary hypertension in a YAP1/TAZ-dependent manner
Journal
Experimental & molecular medicine
Dual-targeted and pH-sensitive Doxorubicin Prodrug-Microbubble Complex with Ultrasound for Tumor Treatment
KIF11 promotes cell proliferation via ERBB2/PI3K/AKT signaling pathway in gallbladder cancer.
Phosphoinositide specific phospholipase Cγ1 inhibition-driven autophagy caused cell death in human lung adenocarcinoma A549 cells in vivo and in vitro
Journal
International Journal of Biological Sciences
Scaffolds Facilitate Epiretinal Transplantation of hiPSC-Derived Retinal Neurons in Nonhuman Primates
miR-301a Suppression within Fibroblasts Limits the Progression of Fibrosis through the TSC1/mTOR Pathway
Journal
Mol Ther Nucleic Acids
circRASGRF2 functions as an oncogenic gene in hepatocellular carcinoma by acting as a miR-1224 sponge
Journal
Mol Ther Nucleic Acids
Exosome-mediated inhibition of microRNA-449a promotes the amplification of mouse retinal progenitor cells and enhances their transplantation in retinal degeneration mouse models - PMC
Journal
Molecular therapy. Nucleic acids
IL1RN mediates the suppressive effect of methionine deprivation on glioma proliferation.
Exosomal LGALS9 in the cerebrospinal fluid of glioblastoma patients suppressed dendritic cell antigen presentation and cytotoxic T-cell immunity
RPN2 is targeted by miR-181c and mediates glioma progression and temozolomide sensitivity via the wnt/-catenin signaling pathway
SNRPB promotes the tumorigenic potential of NSCLC in part by regulating RAB26.
Journal
Cell death & disease
Endolysosomal ion channel MCOLN2 (Mucolipin-2) promotes prostate cancer progression via IL-1β/NF-κB pathway
tRF-3013b inhibits gallbladder cancer proliferation by targeting TPRG1L - PMC
Journal
Cellular & molecular biology letters
NNTinduced tumor cell slimming reverses the procarcinogenesis effect of HIF2a in tumors
Reduction of miR-744 delivered by NSCLC cell-derived extracellular vesicles upregulates SUV39H1 to promote NSCLC progression via activation of the Smad9/BMP9 axis
BAM15 attenuates transportation-induced apoptosis in iPS-differentiated retinal tissue.
Journal
Stem cell research & therapy
Chemical Biopsy for GNMT as Noninvasive and Tumorigenesis-Relevant Diagnosis of Liver Cancer
Journal
Analytical chemistry
Silybum marianum total extract, silymarin and silibinin abate hepatocarcinogenesis and hepatocellular carcinoma growth via modulation of the HGF/c-Met, Wnt/β …
Journal
Biomed Pharmacother
CXCR2 antagonism promotes oligodendrocyte precursor cell differentiation and enhances remyelination in a mouse model of multiple sclerosis
Journal
Neurobiology of disease
Long non-coding RNA (lncRNA) PGM5P4-AS1 inhibits lung cancer progression by up-regulating leucine zipper tumor suppressor (LZTS3) through sponging microRNA miR-1275
MicroRNA-934 facilitates cell proliferation, migration, invasion and angiogenesis in colorectal cancer by targeting B-cell translocation gene 2
In-vitro and in-vivo investigation of amygdalin, metformin, and combination of both against doxorubicin on hepatocellular carcinoma
Anti-inflammatory role and mechanism of microRNA-92b-3p in the progression of hypoxic pulmonary hypertension
Sophflarine A, a novel matrine-derived alkaloid from Sophora flavescens with therapeutic potential for non-small cell lung cancer through ROS-mediated pyroptosis
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Induction of systemic immune responses and reversion of immunosuppression in the tumor microenvironment by a therapeutic vaccine for cervical cancer
Journal
Cancer Immunol Immunother
Simvastatin Inhibits NLRP3 Inflammasome Activation and Ameliorates Lung Injury in Hyperoxia-Induced Bronchopulmonary Dysplasia via the KLF2-Mediated Mechanism
Journal
Oxidative medicine and cellular longevity
A Novel Fibromodulin Antagonist Peptide RP4 Exerts Antitumor Effects on Colorectal Cancer - PMC
Gardenia jasminoides J. Ellis extract alleviated white matter damage through promoting the differentiation of oligodendrocyte precursor cells via suppressing neuroinflammation
Circ_0089823 reinforces malignant behaviors of non-small cell lung cancer by acting as a sponge for microRNAs targeting SOX4
Necroptosis Inhibition by Hydrogen Sulfide Alleviated Hypoxia-Induced Cardiac Fibroblasts Proliferation via Sirtuin 3
FSBP suppresses tumor cell migration by inhibiting the JNK pathway - PMC
Chemopreventive Effect of 5-Flurouracil Polymeric Hybrid PLGA-Lecithin Nanoparticles against Colon Dysplasia Model in Mice and Impact on p53 Apoptosis
Ag120-Mediated Inhibition of ASCT2-Dependent Glutamine Transport has an Anti-Tumor Effect on Colorectal Cancer Cells
Journal
Frontiers in pharmacology
Oxymatrine Inhibits Renal Cell Carcinoma Progression by Suppressing β-Catenin Expression
MicroRNA-532-3p Suppresses Malignant Behaviors of Tongue Squamous Cell Carcinoma via Regulating CCR7.
Journal
Frontiers in Pharmacology
Cisplatin and doxorubicin chemotherapy alters gut microbiota in a murine osteosarcoma model - PMC
Identification of alanine aminotransferase 1 interaction network via iTRAQ-based proteomics in alternating migration, invasion, proliferation and apoptosis of HepG2 cells - PMC
LncRNA HLA-F-AS1 promotes colorectal cancer metastasis by inducing PFN1 in colorectal cancer-derived extracellular vesicles and mediating macrophage polarization
MORC4 plays a tumor-promoting role in colorectal cancer via regulating PCGF1/CDKN1A axis in vitro and in vivo
Journal
Cancer gene therapy
CRHBP is degraded via autophagy and exerts anti-hepatocellular carcinoma effects by reducing cyclin B2 expression and dissociating cyclin B2-CDK1 complex
Journal
Cancer gene therapy
RRM2 Mediates the Anti-Tumor Effect of the Natural Product Pectolinarigenin on Glioblastoma Through Promoting CDK1 Protein Degradation by Increasing Autophagic Flux
Journal
Frontiers in oncology
Micro1278 Leads to Tumor Growth Arrest, Enhanced Sensitivity to Oxaliplatin and Vitamin D and Inhibits Metastasis via KIF5B, CYP24A1, and BTG2, Respectively
Rotundic Acid Induces DNA Damage and Cell Death in Hepatocellular Carcinoma Through AKT/mTOR and MAPK Pathways.
Journal
Frontiers in Oncology
EphA10 drives tumor progression and immune evasion by regulating the MAPK/ERK cascade in lung adenocarcinoma
Journal
International immunopharmacology
Impact of Prenatal Acetaminophen Exposure for Hippocampal Development Disorder on Mice
Journal
Molecular neurobiology
HTRA3 transcriptionally inhibited by FOXP1 suppresses tumorigenesis of osteosarcoma via the PTEN/PI3K/AKT pathway
Journal
Biochimica et biophysica acta. Molecular cell research
Bergenin inhibits bladder cancer progression via activating the PPARγ/PTEN/Akt signal pathway
Ruangan Lidan decoction inhibits the growth and metastasis of liver cancer by downregulating miR-9-5p and upregulating PDK4 - PMC
Journal
Cancer biology & therapy
The role and mechanism of action of RNF186 in colorectal cancer through negative regulation of NF-κB
Raddeanin a Suppresses Glioblastoma Growth by Inducing ROS Generation and Subsequent JNK Activation to Promote Cell Apoptosis
Journal
cellular physiology and biochemistry
Isogambogenic Acid Inhibits the Growth of Glioma Through Activation of the AMPK-mTOR Pathway
Journal
Cellular physiology and biochemistry
MicroRNA-215-5p inhibits the proliferation of keratinocytes and alleviates psoriasis-like inflammation by negatively regulating DYRK1A and its downstream signalling pathways
Journal
Experimental dermatology
Solamargine Inhibits Prostate Cancer Cell Growth and Enhances the Therapeutic Efficacy of Docetaxel via Akt Signaling
Journal
Journal of oncology
Tat-CIRP Peptide Facilitates Frozen Wound Healing by Ameliorating Inflammation and Promoting Angiogenesis - PMC
Journal
Journal of inflammation research
Dihydromyricetin Inhibits Tumor Growth and Epithelial-Mesenchymal Transition through regulating miR-455-3p in Cholangiocarcinoma
Bai-He-Gu-Jin-Tang formula suppresses lung cancer via AKT/GSK3β/β-catenin and induces autophagy via the AMPK/mTORC1/ULK1 signaling pathway
MicroRNA-455-5p Contributes to Cholangiocarcinoma Growth and Mediates Galangin's Anti-Tumor Effects
Establishment and characterization of the third non-functional human pancreatic neuroendocrine tumor cell line
Establishment and characterization of the third non-functional human pancreatic neuroendocrine tumor cell line
TMEM97 is transcriptionally activated by YY1 and promotes colorectal cancer progression via the GSK-3/-catenin signaling pathway
Targeting eIF3f Suppresses the Growth of Prostate Cancer Cells by Inhibiting Akt Signaling.
Journal
OncoTargets and therapy
Exportin XPO7 acts as an oncogenic factor in prostate cancer via upregulation of TCF3
Journal
Journal of cancer research and clinical oncology
Chlorogenic Acid Inhibits Human Glioma U373 Cell Progression via Regulating the SRC/MAPKs Signal Pathway: Based on Network Pharmacology Analysis
Journal
Drug Des Devel Ther
Cadmium exposure-induced rat testicular dysfunction and its mechanism of chronic stress
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Developmental toxicity window of fetal testicular injury in offspring mice induced by prenatal amoxicillin exposure at different time, doses and courses
Journal
Toxicology letters
CLEC12B suppresses lung cancer progression by inducing SHP-1 expression and inactivating the PI3K/AKT signaling pathway
Vimentin loss promotes cancer proliferation through up-regulating Rictor/AKT/β-catenin signaling pathway
Long non-coding RNA BLACAT2/miR-378a-3p/YY1 feedback loop promotes the proliferation, migration and invasion of uterine corpus endometrial carcinoma - PMC
Chemopreventive effect of α-hederin/carboplatin combination against experimental colon hyperplasia and impact on jnk signaling
Journal
Toxicology mechanisms and methods
Upregulated bone morphogenetic protein 5 enhances proliferation and epithelial-mesenchymal transition process in benign prostatic hyperplasia via BMP/Smad signaling pathway
Down regulation of RBM10 promotes proliferation and metastasis via miR-224-5p/RBM10/p53 feedback loop in lung adenocarcinoma - PMC
TRG16, targeted by miR-765, inhibits breast cancer stem cell-like properties via regulating the NF-κB pathway
Journal
Molecular and cellular biochemistry
High methylation of the same promoter of lncRNA ZNF582-AS1/ZNF582 promotes malignant progression of esophageal cancer
Itraconazole inhibits proliferation, induces apoptosis, and reduces angiogenesis of hemangioma endothelial cells by downregulating the hedgehog signaling pathway - PMC
Interleukin-38 Suppresses Cell Migration and Proliferation and Promotes Apoptosis of Colorectal Cancer Cell Through Negatively Regulating Extracellular Signal -Regulated Kinases Signaling
Journal
J Interferon Cytokine Res
Inhibition of Orthotopic Genital Cancer Induced by Subcutaneous Administration of Human Papillomavirus Peptide Vaccine with CpG Oligodeoxynucleotides as an Adjuvant in Mice
Inhibiting effect of microRNA-187-3p on osteogenic differentiation of osteoblast precursor cells by suppressing cannabinoid receptor type 2.
Journal
Differentiation; research in biological diversity
PAQR4 promotes the development of hepatocellular carcinoma by activating PI3K/AKT pathway
Journal
Acta Biochim Biophys Sin (Shanghai)
MiR-135b promotes HCC tumorigenesis through a positive-feedback loop
Journal
Biochem Biophys Res Commun
FTO accelerates ovarian cancer cell growth by promoting proliferation, inhibiting apoptosis, and activating autophagy
Sanguinarine inhibits the tumorigenesis of gastric cancer by regulating the TOX/DNA-PKcs/ KU70/80 pathway
Journal
Pathology, Research and Practice
The role of β-HCG and VEGF-MEK/ERK signaling pathway in villi angiogenesis in patients with missed abortion
CM082, a novel angiogenesis inhibitor, enhances the antitumor activity of gefitinib on epidermal growth factor receptor mutant non-small cell lung cancer in vitro and in vivo
Species
Homo sapiens, Mus musculus
LncRNA RHPN1-AS1 accelerates proliferation, migration, and invasion via regulating miR-485-5p/BSG axis in hepatocellular carcinoma
Journal
Naunyn Schmiedebergs Arch Pharmacol
The optimized research of the in vitro culture of preantral follicles in mice.
Obvious morphologic changes in the mandible and condylar cartilage after triple botulinum toxin injections into the bilateral masseter
Journal
Am J Orthod Dentofacial Orthop
KDM1A and KDM3A promote tumor growth by upregulating cell cycle-associated genes in pancreatic cancer
Journal
Exp Biol Med (Maywood)
Arisaema heterophyllum Blume Monomer Stigmasterol Targets PPARγ and Inhibits the Viability and Tumorigenicity of Lung Adenocarcinoma Cells NCI-H1975 - PMC
Journal
Evidence-based complementary and alternative medicine : eCAM
Metformin Synergizes with PD-L1 Monoclonal Antibody Enhancing Tumor Immune Response in Treating Non-Small Cell Lung Cancer and Its Molecular Mechanism Investigation - PMC
Journal
Evidence-based complementary and alternative medicine : eCAM
Paeoniflorin accelerates foot wound healing in diabetic rats though activating the Nrf2 pathway
β-elemene suppresses the malignant behavior of esophageal cancer cells by regulating the phosphorylation of AKT
Correlation of 3'-Phosphoadenosine-5'-Phosphosulfate synthase 1 (PAPSS1) expression with clinical parameters and prognosis in esophageal squamous …
Journal
Histology and histopathology
miR-483-5p aggravates cisplatin-induced premature ovarian insufficiency in rats by targeting FKBP4
Journal
Nan Fang Yi Ke Da Xue Xue Bao