Porous microneedle patch with sustained delivery of extracellular vesicles mitigates severe spinal cord injury - PMC
Journal
Nature communications
AGGF1 therapy inhibits thoracic aortic aneurysms by enhancing integrin α7-mediated inhibition of TGF-β1 maturation and ERK1/2 signaling - PMC
Journal
Nature communications
InflammationResponsive Hydrogel Spray for Synergistic Prevention of Traumatic Heterotopic Ossification via DualHomeostatic Modulation Strategy
Journal
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Lighting up metastasis process before formation of secondary tumor by phosphorescence imaging - PMC
Activation of hepatic adenosine A1 receptor ameliorates MASH via inhibiting SREBPs maturation
Journal
Cell reports. Medicine
Clusterin negatively modulates mechanical stress-mediated ligamentum flavum hypertrophy through TGF-β1 signaling
Journal
Experimental & molecular medicine
Ex Vivo Evaluation of Combination Immunotherapy Using TumorMicroenvironmentonChip
Journal
Advanced healthcare materials
MiR-30c protects diabetic nephropathy by suppressing epithelial-to-mesenchymal transition in db/db mice
Gradient Rotating Magnetic Fields Impairing F-Actin-Related Gene CCDC150 to Inhibit Triple-Negative Breast Cancer Metastasis by Inactivating TGF-1/SMAD3 Signaling Pathway - PMC
Journal
Research (Washington, D.C.)
Oxidative stress mediated by the TLR4/NOX2 signalling axis is involved in polystyrene microplastic-induced uterine fibrosis in mice
Journal
The Science of the total environment
Structural analysis and attenuates hyperuricemic nephropathy of dextran from the Imperata cylindrica Beauv. var. major (Nees) CE Hubb.
Journal
Carbohydrate polymers
Redox Dysregulation of Vascular Smooth Muscle Sirtuin-1 in Thoracic Aortic Aneurysm in Marfan Syndrome
Journal
Arteriosclerosis, thrombosis, and vascular biology
Inhaled polystyrene nanoplastics induced liver injury and fibrosis by activating ferroptosis pathways
Journal
The Science of the total environment
Substantia nigra Smad3 signaling deficiency: relevance to aging and Parkinson’s disease and roles of microglia, proinflammatory factors, and MAPK
Journal
Journal of Neuroinflammation
Chronic kidney disease activates the HDAC6-inflammatory axis in the heart and contributes to myocardial remodeling in mice: inhibition of HDAC6 alleviates chronic
Journal
Basic research in cardiology
Dapagliflozin: a sodium-glucose cotransporter 2 inhibitor, attenuates angiotensin II-induced cardiac fibrotic remodeling by regulating TGF1/Smad signaling
Journal
Cardiovasc Diabetol
Two-way immune effects of deoxynivalenol in weaned piglets and porcine alveolar macrophages: Due mainly to its exposure dosage
Targeting antioxidant factor Nrf2 by raffinose ameliorates lipid dysmetabolism-induced pyroptosis, inflammation and fibrosis in NAFLD
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Characterization of TGF-β by Induced Oxidative Stress in Human Trabecular Meshwork Cells
Journal
Antioxidants (Basel)
Biochanin A Ameliorates Nephropathy in High-Fat Diet/Streptozotocin-Induced Diabetic Rats: Effects on NF-kB/NLRP3 Axis, Pyroptosis, and Fibrosis - PMC
Journal
Antioxidants (Basel, Switzerland)
Effects of cholecalciferol cholesterol emulsion on renal fibrosis and aquaporin 2 and 4 in mice with unilateral ureteral obstruction
Journal
biomedicine & pharmacotherapy
Ginsenoside Rg1 ameliorates hypoxia-induced pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition and inflammation by
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
MiR-146a reduces fibrosis after glaucoma filtration surgery in rats - PMC
Journal
Journal of translational medicine
Benzoylaconitine: A promising ACE2-targeted agonist for enhancing cardiac function in heart failure
Journal
Free radical biology & medicine
Differences in the characteristics and pulmonary toxicity of nano- and micron-sized respirable coal dust - PMC
Journal
Respiratory research
Coal dust nanoparticles induced pulmonary fibrosis by promoting inflammation and epithelial-mesenchymal transition via the NF-B/NLRP3 pathway driven by IGF1/ROS-mediated AKT/GSK3 signals - PMC
Journal
Cell death discovery
Species
Homo sapiens, Mus musculus
Biochanin A alleviates unilateral ureteral obstruction-induced renal interstitial fibrosis and inflammation by inhibiting the TGF-1/Smad2/3 and NF-kB/NLRP3 signaling axis in mice
Bone mesenchymal stem cells promote gastric cancer progression through TGF-β1/Smad2 positive feedback loop
Aloin alleviates pathological cardiac hypertrophy via modulation of the oxidative and fibrotic response
Schisantherin A ameliorates liver fibrosis through TGF-β1mediated activation of TAK1/MAPK and NF-κB pathways in vitro and in vivo
miR‐448‐3p alleviates diabetic vascular dysfunction by inhibiting endothelial–mesenchymal transition through DPP‐4 dysregulation
Involvement of TGF-β and ROS in G1 Cell Cycle Arrest Induced by Titanium Dioxide Nanoparticles Under UVA Irradiation in a 3D Spheroid Model
Journal
International Journal of Nanomedicine
Carvacrol preserves antioxidant status and attenuates kidney fibrosis via modulation of the TGF-1/Smad signaling and inflammation
The role of transforming growth factor-beta in retinal ganglion cells with hyperglycemia and oxidative stress
Journal
International journal of molecular sciences
Layered Double Hydroxides-Loaded Sorafenib Inhibit Hepatic Stellate Cells Proliferation and Activation In Vitro and Reduce Fibrosis In Vivo
- PMC
Journal
Frontiers in bioengineering and biotechnology
Carnosic Acid Alleviates BDL-Induced Liver Fibrosis through miR-29b-3p-Mediated Inhibition of the High-Mobility Group Box 1/Toll-Like Receptor 4 Signaling Pathway in Rats.
Journal
Frontiers in Pharmacology
Alpha-hederin reprograms multi-miRNAs activity and overcome small extracellular vesicles-mediated paclitaxel resistance in NSCLC - PMC
Journal
Frontiers in pharmacology
The role played by ailanthone in inhibiting bone metastasis of breast cancer by regulating tumor-bone microenvironment through the RANKL-dependent pathway - PMC
Journal
Frontiers in pharmacology
Deficiency of flavin-containing monooxygenase 3 protects kidney function after ischemia-reperfusion in mice - PMC
Journal
Communications biology
Long-Time Instead of Short-Time Exposure in Vitro and Administration in Vivo of Ochratoxin A Is Consistent in Immunosuppression
Journal
Journal of agricultural and food chemistry
PDPN contributes to constructing immunosuppressive microenvironment in IDH wildtype glioma
Journal
Cancer gene therapy
Intranasal administration of β‐1, 3‐galactosyltransferase 2 confers neuroprotection against ischemic stroke by likely inhibiting oxidative stress and NLRP3 …
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Osteopontin Regulation of MerTK Macrophages Promotes Crohn's Disease Intestinal Fibrosis
Species
Homo sapiens,Mus musculus
Investigating dysregulation of TGF-1/SMAD3 signaling in Atopic Dermatitis: A Molecular and Immunohistochemical Analysis
Journal
Clinical and experimental immunology
Telbivudine attenuates UUO-induced renal fibrosis via TGF-/Smad and NF-B signaling
Journal
International Immunopharmacology
Phosphorylation of low density lipoprotein receptor-related protein 6 is involved in receptor for advanced glycation end product-mediated -catenin stabilization in a toluene diisocyanate-induced asthma model
Journal
International immunopharmacology
Dioscin ameliorates cisplatin-induced intestinal toxicity by mitigating oxidative stress and inflammation
Journal
International immunopharmacology
Fumonisin B1 induces nephrotoxicity via autophagy mediated by mTORC1 instead of mTORC2 in human renal tubule epithelial cells
Therapeutic application of nicotinamide: As a potential target for inhibiting fibrotic scar formation following spinal cord injury - PMC
Journal
CNS neuroscience & therapeutics
Inula japonica ameliorated bleomycin-induced pulmonary fibrosis via inhibiting soluble epoxide hydrolase
Journal
Bioorganic chemistry
Pirfenidone alleviates cardiac fibrosis induced by pressure overload via inhibiting TGF-1/Smad3 signalling pathway - PMC
Journal
Journal of cellular and molecular medicine
Wound-Healing Potential of Rhoifolin-Rich Fraction Isolated from Sanguisorba officinalis Roots Supported by Enhancing Re-Epithelization, Angiogenesis, Anti-Inflammatory, and Antimicrobial Effects
Journal
Pharmaceuticals (Basel, Switzerland)
Nootkatone confers antifibrotic effect by regulating the TGF-β/Smad signaling pathway in mouse model of unilateral ureteral obstruction
Quyu Shengxin capsule (QSC) inhibits Ang-II-induced abnormal proliferation of VSMCs by down-regulating TGF-, VEGF, mTOR and JAK-STAT pathways
Journal
Journal of ethnopharmacology
Imperatorin ameliorates kidney injury in diabetic mice by regulating the TGF-/Smad2/3 signaling axis, epithelial-to-mesenchymal transition, and renal inflammation
Journal
European journal of pharmacology
Bletilla striata polysaccharide attenuated the progression of pulmonary fibrosis by inhibiting TGF-1/Smad signaling pathway
Journal
Journal of ethnopharmacology
Alternanthera brasiliana L. extract alleviates carbon tetrachloride-induced liver injury and fibrotic changes in mice: Role of matrix metalloproteinases and TGF-β/Smad …
Journal
Journal of ethnopharmacology
Single-cell sequencing reveals the impact of endothelial cell PIEZO1 expression on thoracic aortic aneurysm
Journal
Journal of molecular and cellular cardiology
Inhibitory effects of Schisandrin C on collagen behavior in pulmonary fibrosis - PMC
Journal
Scientific reports
ADAM12 is an independent predictor of poor prognosis in liver cancer
Journal
Scientific reports
The silencing of NREP aggravates OA cartilage damage through the TGF-1/Smad2/3 pathway in chondrocytes - PMC
Journal
Journal of orthopaedic translation
Species
Homo sapiens, Mus musculus
Nicorandil alleviates cardiac remodeling and dysfunction post-infarction by up-regulating the nucleolin/autophagy axis
Journal
Cellular signalling
Development and optimization of the Glabridin-loaded dissolving microneedle for enhanced treatment of keloid - PMC
Journal
International journal of pharmaceutics: X
Species
Oryctolagus cuniculus
Cadherin-11 Deficiency Attenuates Ang-II-Induced Atrial Fibrosis and Susceptibility to Atrial Fibrillation
Species
Homo sapiens, Mus musculus
TMT proteomics analysis reveals the mechanism of bleomycin-induced pulmonary fibrosis and effects of Ginseng honeysuckle superfine powdered tea - PMC
Identification of the Main Chemical constituents and mechanism of Renshen Guben oral liquid against Renal Fibrosis - PMC
Arsenic exposure induced renal fibrosis via regulation of mitochondrial dynamics and the NLRP3TGF1/SMAD signaling pathway
Journal
Environmental toxicology
Species
Homo sapiens,Rattus norvegicus
Dysregulated lipid metabolism is associated with kidney allograft fibrosis - PMC
Journal
Lipids in health and disease
Exposure to BPA and BPS during pregnancy disrupts the bone mineralization in the offspring
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
-1, 3-galactosyltransferase 2 ameliorates focal ischemic cerebral injury by maintaining blood-brain barrier integrity
Journal
Neurochemistry international
Radiation-induced H3K9 tri-methylation in E-cadherin promoter during lung EMT: In vitro and in vivo approaches using Vanillin
H2S alleviates aortic aneurysm and dissection: Crosstalk between transforming growth factor 1 signaling and NLRP3 inflammasome
Nerolidol attenuates airway inflammation and airway remodeling and alters gut microbes in ovalbumininduced asthmatic mice
Journal
Cell biochemistry and function
Endoplasmic reticulum stress promotes endometrial fibrosis through the TGF-/SMAD pathway
Journal
Reproduction (Cambridge, England)
Knockdown of KDM2A inhibits proliferation associated with TGF-β expression in HEK293T cell.
Journal
Molecular and cellular biochemistry
Surfactant protein D regulates murine testicular immune milieu and sperm functions
Journal
American Journal of Reproductive Immunology
Premature senescence of cardiac fibroblasts and atrial fibrosis in patients with atrial fibrillation
Gallic acid-coated sliver nanoparticle alters the expression of radiation-induced epithelial-mesenchymal transition in non-small lung cancer cells.
Journal
Toxicology in Vitro
Radiation-induced H3K9 methylation on E-cadherin promoter mediated by ROS/Snail axis : Role of G9a signaling during lung epithelial-mesenchymal transition
Protective effects of epigallocatechin-3-o-gallate combined with organic selenium against transforming growth factor-beta 1-induced fibrosis in LX-2 cells
Journal
Journal of food biochemistry
Exogenous Spermidine Alleviates Diabetic Myocardial Fibrosis Via Suppressing Inflammation and Pyroptosis in db/db Mice - PMC
Journal
Balkan medical journal
Antiskin aging effect of sea buckthorn proanthocyanidins in Dgalactoseinduced aging mice
Journal
Food science & nutrition
Downregulation of lysyl oxidase in venous malformations: Association with vascular destabilization and sclerotherapy
Journal
The Journal of Dermatology
Dicoumarol attenuates NLRP3 inflammasome activation to inhibit inflammation and fibrosis in knee osteoarthritis - PMC
Journal
Molecular medicine reports
Effect of Trichostatin A on radiation induced epithelial-mesenchymal transition in A549?cells
Journal
Biochemical And Biophysical Research Communications
Study on effects and relevant mechanisms of Mudan granules on renal fibrosis in streptozotocin-induced diabetes rats
Matrine Suppresses Pancreatic Fibrosis by Regulating TGF-β/Smad Signaling in Rats.
Journal
Yonsei medical journal
All-Trans Retinoic Acid Promotes M2 Macrophage Polarization in Vitro by Activating the p38MAPK/STAT6 Signaling Pathway
Journal
Immunological investigations
GOLM1 Promotes Epithelial-Mesenchymal Transition by Activating
TGF1/Smad2 Signaling in Prostate Cancer - PMC
Journal
Technology in cancer research & treatment
IGFBP3 inhibits angiotensin II‐induced aortic smooth muscle cell phenotypic switch and MMPs expression
Flavonoid Extract from Propolis Inhibits Cardiac Fibrosis Triggered by Myocardial Infarction through Upregulation of SIRT1.
Journal
Evidence-based Complementary and Alternative Medicine
Ketogenic diet induces autophagy to alleviate bleomycin-induced pulmonary fibrosis in murine models
Ba-Wei-Die-Huang-Wan (Hachimi-jio-gan) can ameliorate ketamine-induced cystitis by modulating neuroreceptors, inflammatory mediators, and fibrogenesis in a rat model.
Journal
Neurourology and Urodynamics
Shenkang VII Recipe Attenuates Unilateral Ureteral Obstruction-induced Renal Fibrosis via TGF-β/Smad, NF-κB and SHH Signaling Pathway
Vinpocetine, a phosphodiesterase 1 inhibitor, mitigates atopic dermatitis-like skin inflammation - PMC
Journal
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology
Suppression of ADAM8 attenuates angiotensin II-induced cardiac fibrosis and endothelial-mesenchymal transition via inhibiting TGF-β1/Smad2/Smad3 pathways
Journal
Experimental animals