The Circadian Protein Period2 Suppresses mTORC1 Activity via Recruiting Tsc1 to mTORC1 Complex.
Influenza M2 protein regulates MAVS-mediated signaling pathway through interacting with MAVS and increasing ROS production
C9orf72 controls hepatic lipid metabolism by regulating SREBP1 transport
Journal
Cell death and differentiation
Injectable dexamethasone-loaded peptide hydrogel for therapy of radiation-induced ototoxicity by regulating the mTOR signaling pathway
Journal
Journal of controlled release : official journal of the Controlled Release Society
ZNPs reduce epidermal mechanical strain resistance by promoting desmosomal cadherin endocytosis via mTORC1-TFEB-BLOC1S3 axis - PMC
Journal
Journal of nanobiotechnology
Biphasic regulation of osteoblast development via the ERK MAPK-mTOR pathway - PMC
Species
Homo sapiens,Mus musculus
Low WIP1 Expression Accelerates Ovarian Aging by Promoting Follicular Atresia and Primordial Follicle Activation - PMC
Picornavirus infection enhances aspartate by the SLC38A8 transporter to promote viral replication - PMC
Hernandezine induces autophagic cell death in human pancreatic cancer cells via activation of the ROS/AMPK signaling pathway
Journal
Acta pharmacologica Sinica
Canagliflozin Modulates Hypoxia-Induced Metastasis, Angiogenesis and Glycolysis by Decreasing HIF-1α Protein Synthesis via AKT/mTOR Pathway
Journal
International journal of molecular sciences
Bacteroides-derived isovaleric acid enhances mucosal immunity by facilitating intestinal IgA response in broilers - PMC
Journal
Journal of animal science and biotechnology
Bergenin Alleviates Ulcerative Colitis By Decreasing Gut Commensal Bacteroides vulgatus-Mediated Elevated Branched-Chain Amino Acids
Journal
Journal of agricultural and food chemistry
Anhydroicaritin improves diet-induced obesity and hyperlipidemia and alleviates insulin resistance by suppressing SREBPs activation
Journal
Biochemical Pharmacology
Ag120-Mediated Inhibition of ASCT2-Dependent Glutamine Transport has an Anti-Tumor Effect on Colorectal Cancer Cells
Journal
Frontiers in pharmacology
Maintaining Toll signaling in Drosophila brain is required to sustain autophagy for dopamine neuron survival - PMC
Species
Drosophila melanogaster
HRK inhibits colorectal cancer cells proliferation by suppressing the PI3K/AKT/mTOR pathway - PMC
Journal
Frontiers in oncology
Corynoxine B ameliorates HMGB1-dependent autophagy dysfunction during manganese exposure in SH-SY5Y human neuroblastoma cells.
Journal
Food and chemical toxicology
CircNDST1 promotes papillary thyroid cancer progression via its interaction with CSNK2A1 to activate the PI3K–Akt pathway and epithelial–mesenchymal …
Journal
Journal of endocrinological investigation
Autophagy induced by Vip3Aa has a pro-survival role in Spodoptera frugiperda Sf9 cells
Species
Spodoptera frugiperda
Hyperoside attenuates pregnancy loss through activating autophagy and suppressing inflammation in a rat model
Urolithin A suppresses tumor progression and induces autophagy in gastric cancer via the PI3K/Akt/mTOR pathway
Journal
Drug development research
Morusin Enhances Temozolomide Efficiency in GBM by Inducing Cytoplasmic Vacuolization and Endoplasmic Reticulum Stress - PMC
Journal
Journal of clinical medicine
Maackiain suppresses the development of cervical cancer via AMPK priming autophagy
Journal
The Journal of pharmacy and pharmacology
dCas9guided demethylation of the AKT1 promoter improves milk protein synthesis in a bovine mastitis mammary gland epithelial model induced by using
Journal
Cell biology international
Targeting SLC1A5 blocks cell proliferation through inhibition of mTORC1 in arsenite-treated human uroepithelial cells
Ligusticum chuanxiong promotes the angiogenesis of preovulatory follicles (F1-F3) in late-phase laying hens
iTRAQ-based comparative proteomic analysis of Vero cells infected with virulent and CV777 vaccine strain-like strains of porcine epidemic diarrhea virus
Journal
Journal Of Proteomics
MARCH1 negatively regulates TBK1-mTOR signaling pathway by ubiquitinating TBK1 - PMC
Endogenous Aβ induces osteoporosis through an mTOR-dependent inhibition of autophagy in bone marrow mesenchymal stem cells (BMSCs)
Journal
Annals of translational medicine
Diosgenin inhibits the proliferation of gastric cancer cells via inducing mesoderm posterior 1 down-regulation-mediated alternative reading frame expression
Glucose Regulates Glucose Transport and Metabolism via mTOR Signaling Pathway in Bovine Placental Trophoblast Cells
Journal
Animals : an open access journal from MDPI