Recombinant protein (or fragment).This information is considered to be commercially sensitive.
克隆号
ARC56720
产品形式
Liquid
偶联物
ABflo® 647. Ex:648nm. Em:664nm.
克隆号
ARC56720
产品形式
Liquid
偶联物
ABflo® 647. Ex:648nm. Em:664nm.
细胞定位
Cell surface, External side of plasma membrane, Extracellular exosome, Extracellular space, Focal adhesion, Plasma membrane.
存储缓冲液
Store at 2-8℃. Avoid freeze. Buffer: PBS containing 0.2% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.
