Flow cytometry analysis of human PBMCs using ABflo® 594 Rabbit anti-Human CD62L/L-Selectin mAb (A24632), PE Mouse anti-Human CD3 mAb (A22795), ABflo® 488 Rabbit anti-Human/Monkey CD4 mAb (A22773), APC Rabbit anti-Human/Monkey CD8a mAb (A24799) and ABflo® 594 Rabbit anti-Human CD38 mAb (A24366) clearly classified positive and negative cells.
This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene.
