Recombinant protein (or fragment).This information is considered to be commercially sensitive.
克隆号
ARC5024
产品形式
Liquid
偶联物
ABflo® 610. Ex:421nm. Em:612nm.
克隆号
ARC5024
产品形式
Liquid
偶联物
ABflo® 610. Ex:421nm. Em:612nm.
细胞定位
Membrane, Membrane raft, Single-pass type I membrane protein.
存储缓冲液
Store at 2-8℃. Avoid freeze. Buffer: PBS containing 0.2% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis), pH 7.3.
Flow Cytometry analysis of human PBMCs, using PE Rabbit anti-Human CD4 mAb (A26596), ABflo® 610 Rabbit anti-Human CD45 mAb (A25823), PerCP/Cyanine5.5 Rabbit anti-Human/Monkey CD8a mAb (A26221) and ABflo® 488 Rabbit anti-Human/Monkey CD3 mAb (A26283), clearly classified positive and negative cells.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported.
