Flow Cytometry analysis of human PBMCs, using ABflo® 450 Rabbit anti-Human/Monkey CD45 mAb (A25195), APC Rabbit anti-Human CD66b mAb (A26616), ABflo® 488 Rabbit anti-Human CD4 mAb (A26597), PE/Cyanine7 Rabbit anti-Human/Monkey CD8a mAb (A27308) and ABflo® 700 Rabbit anti-Human/Monkey CD19 mAb (A27165). The staining clearly distinguished between positive and negative cell populations.
Flow Cytometry analysis of human whole blood, using PE Rabbit anti-Human/Mouse FOXP3 mAb (A27686) and ABflo® 488 Rabbit anti-Human CD4 mAb (A26597). The staining clearly distinguished between positive and negative cell populations.
This gene encodes the CD4 membrane glycoprotein of T lymphocytes. The CD4 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules. The CD4 antigen is also a primary receptor for entry of the human immunodeficiency virus through interactions with the HIV Env gp120 subunit. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, granulocytes, as well as in various regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene.
