CD16 is also known as Fcgr3 and is a 50-65 kd type I transmembrane protein. It is a member of the Fcγ receptor family and the Ig superfamily. CD16 is expressed on most myeloid cells, including monocytes, macrophages, and dendritic cells. NK cells and NKT cells also express CD16. CD16 is involved in cell activation, phagocytosis, and antibody-dependent cell-mediated cytotoxicity (ADCC); its ligands are IgG1, IgG2a, and IgG2b.
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