Bone-targeting engineered small extracellular vesicles carrying anti-miR-6359-CGGGAGC prevent valproic acid-induced bone loss - PMC
Journal
Signal transduction and targeted therapy
A Rational Design of Metal-Organic Framework Nanozyme with High-Performance Copper Active Centers for Alleviating Chemical Corneal Burns - PMC
Journal
Nano-micro letters
Unspliced XBP1 Counteracts -Catenin to Inhibit Vascular Calcification
Journal
Circulation Research
P-gp expression inhibition mediates placental glucocorticoid barrier opening and fetal weight loss
Species
Homo sapiens, Mus musculus, Rattus norvegicus
Microarray analysis of gene expression differences in microglia after exposure to graphene quantum dots
Journal
The Science of the total environment
CircRNA-IGLL1/miR-15a/RNF43 axis mediates ammonia-induced autophagy in broilers jejunum via Wnt/-catenin pathway
Flavonoid-rich sesame leaf extract-mediated synthesis of nanozymes: Extraction optimization, chemical composition identification and bioactivity evaluation
Targeting antioxidant factor Nrf2 by raffinose ameliorates lipid dysmetabolism-induced pyroptosis, inflammation and fibrosis in NAFLD
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Discovery of Novel Pterostilbene Derivatives That Might Treat Sepsis by Attenuating Oxidative Stress and Inflammation through Modulation of MAPKs/NF-κB Signaling Pathways
Journal
Antioxidants (Basel)
FGF4 promotes skin wound repair through p38 MAPK and GSK3β-mediated stabilization of Slug
Journal
The Journal of investigative dermatology
Cordycepin protects islet β-cells against glucotoxicity and lipotoxicity via modulating related proteins of ROS/JNK signaling pathway
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Design, synthesis, and SAR study of novel 4,5-dihydropyrazole-Thiazole derivatives with anti-inflammatory activities for the treatment of sepsis
JNK molecule is a toxic target for IPEC-J2 cell barrier damage induced by T-2 toxin
Journal
Ecotoxicology and environmental safety
FK866 attenuates sepsis-induced acute lung injury through c-jun-N-terminal kinase (JNK)-dependent autophagy
Glabridin Ameliorates Alcohol-Caused Liver Damage by Reducing Oxidative Stress and Inflammation via p38 MAPK/Nrf2/NF-B Pathway - PMC
Chemical constituents and anti-inflammatory activity of the total alkaloid extract from Melodinus cochinchinensis (Lour.) Merr. and its inhibition of the NF-κB and MAPK signaling pathways
Species
Melodinus cochinchinensis
Sophflarine A, a novel matrine-derived alkaloid from Sophora flavescens with therapeutic potential for non-small cell lung cancer through ROS-mediated pyroptosis
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Improved colonic inflammation by nervonic acid via inhibition of NF-κB signaling pathway of DSS-induced colitis mice
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
Total saponins of panax ginseng via the CX3CL1/CX3CR1 axis attenuates neuroinflammation and exerted antidepressant‐like effects in chronic unpredictable mild …
Journal
Phytotherapy research : PTR
Downregulation of VPS13C promotes cisplatin resistance in cervical cancer by upregulating GSTP1 - PMC
Maresin 1 protects against lipopolysaccharide/d-galactosamine-induced acute liver injury by inhibiting macrophage pyroptosis and inflammatory response
Cajaninstilbene Acid Ameliorates Acetaminophen-Induced Liver Injury Through Enhancing Sestrin2/AMPK-Mediated Mitochondrial Quality Control
Journal
Frontiers in pharmacology
Characterizations and the Mechanism Underlying Osteogenic Activity of Peptides from Enzymatic Hydrolysates of Stichopus japonicus
ADAMTS8 Promotes Cardiac Fibrosis Partly Through Activating EGFR Dependent Pathway
Journal
Frontiers in cardiovascular medicine
Species
Homo sapiens,Rattus norvegicus
Nicotinamide mononucleotide-elicited NAMPT signaling activation aggravated adjuvant-induced arthritis in rats by affecting peripheral immune cells differentiation
Journal
Int Immunopharmacol
Imperatorin reduces the inflammatory response of atherosclerosis by regulating MAPKs signaling pathway in vivo and in vitro
Journal
International Immunopharmacology
Puerarin improves diabetic wound healing via regulation of macrophage M2 polarization phenotype - PMC
Nuciferine alleviates intestinal inflammation by inhibiting MAPK/NF-κB and NLRP3/Caspase 1 pathways in vivo and in vitro
Journal
International immunopharmacology
Knockdown of EIF4G1 in NSCLC induces CXCL8 secretion - PMC
Journal
Frontiers in pharmacology
Korean Red Ginseng Improves Oxidative Stress-Induced Hepatic Insulin Resistance via Enhancing Mitophagy - PMC
Journal
Foods (Basel, Switzerland)
Anneslea fragrans Wall. ameliorates ulcerative colitis via inhibiting NF-κB and MAPK activation and mediating intestinal barrier integrity
Tetrahydroalstonine possesses protective potentials on palmitic acid stimulated SK-N-MC cells by suppression of A1-42 and tau through regulation of PI3K/Akt
Journal
European journal of pharmacology
Cepharanthine Exerts Antioxidant and Anti-Inflammatory Effects in Lipopolysaccharide (LPS)-Induced Macrophages and DSS-Induced Colitis Mice - PMC
Journal
Molecules (Basel, Switzerland)
Adipose stem cells-derived small extracellular vesicles transport Thrombospondin 1 cargo to promote insulin resistance in gestational diabetes mellitus - PMC
Journal
Diabetology & metabolic syndrome
Nephroprotective Role of Chrysophanol in Hypoxia/Reoxygenation-Induced Renal Cell Damage via Apoptosis, ER Stress, and Ferroptosis.
High-fat-diet induced inflammation and apoptosis via activation of Ire1 in liver and hepatocytes of black seabream (Acanthopagrus schlegelii)
Journal
Fish & shellfish immunology
Species
Spondyliosoma cantharus
Suppression of mir-1505p attenuates the anti-inflammatory effect of glucocorticoids in mice with ulcerative colitis
Journal
Molecular immunology
ACE2 Suppresses the Inflammatory Response in LPS-induced Porcine Intestinal Epithelial Cells Via Regulating the NF-κB and MAPK Pathways
Low let-7d microRNA levels in chick embryos enhance innate immunity against Mycoplasma gallisepticum by suppressing the mitogen-activated protein kinase pathway - PMC
Journal
Veterinary research
Botulinum toxin type A activates protective autophagy by modulating endoplasmic reticulum stress in hypoxia/reoxygenation-treated endothelial cells - PMC
The polysaccharide from Camellia oleifera fruit shell enhances immune responses via activating MAPKs and NF-κB signaling pathways in RAW264.7 macrophages - PMC
Journal
Food & nutrition research
PPM1G regulates hepatic ischemia/reperfusion injury through STING-mediated inflammatory pathways in macrophages - PMC
Journal
Immunity, inflammation and disease
Inhibited Expression of NLRP12 Promotes the Development of Triple-Negative Breast Cancer by Activating the NF-B Pathway
Journal
Cell biochemistry and biophysics
PP2Ac knockdown attenuates lipotoxicity-induced pancreatic -cell dysfunction and apoptosis - PMC
Journal
Experimental and therapeutic medicine
Chrysophanol Prevents Lipopolysaccharide-Induced Hepatic Stellate Cell Activation by Upregulating Apoptosis, Oxidative Stress, and the Unfolded Protein Response
Journal
Evid Based Complement Alternat Med
Wild Bitter Melon Extract Regulates LPS-Induced Hepatic Stellate Cell Activation, Inflammation, Endoplasmic Reticulum Stress, and Ferroptosis
Journal
Evid Based Complement Alternat Med
Antipharyngitis Effects of Syringa oblata L. Ethanolic Extract in Acute Pharyngitis Rat Model and Anti-Inflammatory Effect of Ir-Idoids in LPS-Induced RAW 264.7 Cells
Journal
Evid Based Complement Alternat Med
Protective Effects of Anwulignan against HCl/Ethanol-Induced Acute Gastric Ulcer in Mice
Journal
Evid Based Complement Alternat Med
Schisandrin B inhibits α-melanocyte-stimulating hormone-induced melanogenesis in B16F10 cells via downregulation of MAPK and CREB signaling pathways
Journal
Bioscience, biotechnology, and biochemistry
Hypoglycemic effect of acidic polysaccharide from schisandra chinensis on T2D rats induced by high-fat diet combined with STZ
Journal
Biological & pharmaceutical bulletin
Endothelial DR6 in blood-brain barrier malfunction in Alzheimers disease - PMC
Journal
Cell death & disease
SMURF1 attenuates endoplasmic reticulum stress by promoting the degradation of KEAP1 to activate NRF2 antioxidant pathway - PMC
Journal
Cell death & disease
Combining an in silico approach with an animal experiment to investigate the protective effect of troxerutin for treating acute lung injury
Journal
BMC complementary and alternative medicine