Injectable self-healing hydrogel with siRNA delivery property for sustained STING silencing and enhanced therapy of intervertebral disc degeneration
Dissociation of nanosilicates induces downstream endochondral differentiation gene expression program
Transforming growth factor- receptor 1: an intervention target for genetic poor cartilage quality induced by prenatal dexamethasone exposure
Journal
Journal of advanced research
N‐acetylcysteine‐derived Carbon Dots for Free Radical Scavenging in Intervertebral Disc Degeneration
Journal
Advanced healthcare materials
3D Bioprinting Using Synovium-Derived MSC-Laden Photo-Cross-Linked ECM Bioink for Cartilage Regeneration
Journal
ACS applied materials & interfaces
Rescue of nucleus pulposus cells from an oxidative stress microenvironment via glutathione-derived carbon dots to alleviate intervertebral disc degeneration - PMC
Journal
Journal of nanobiotechnology
EVs from cells at the early stages of chondrogenesis delivered by injectable SIS dECM promote cartilage regeneration - PMC
Journal
Journal of tissue engineering
Species
Homo sapiens,Rattus norvegicus
Modulation of apoptosis and Inflammasome activation in chondrocytes: co-regulatory role of Chlorogenic acid - PMC
Journal
Cell communication and signaling : CCS
Membrane vesicles from Lactobacillus johnsonii delay osteoarthritis progression via modulating macrophage glutamine synthetase/mTORC1 axis
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Patchouli Alcohol Inhibits D-Gal Induced Oxidative Stress and Ameliorates the Quality of Aging Cartilage via Activating the Nrf2/HO-1 Pathway in Mice - PMC
Journal
Oxidative medicine and cellular longevity
Effect of total flavonoids of Rhizoma Drynariae in thiram induced cytotoxicity of chondrocyte via BMP-2/Runx2 and IHH/PTHrP expressions
Journal
Ecotoxicology and environmental safety
Cluster of differentiation 147 (CD147) expression is linked with thiram induced chondrocyte's apoptosis via Bcl-2/Bax/Caspase-3 signalling in tibial growth plate under chlorogenic acid repercussion
Journal
Ecotoxicol Environ Saf
Zinc finger protein 521 attenuates osteoarthritis via the histone deacetylases 4 in the nucleus - PMC
Chlorogenic acid suppresses mitochondrial apoptotic effectors Bax/Bak to counteract Nod-like receptor pyrin domain 3 (NLRP3) inflammasome in thiram exposed chondrocytes
Chlorogenic acid suppresses miR-460a in the regulation of Bcl-2, causing interleukin-1 reduction in thiram exposed chondrocytes via caspase-3/caspase-7 pathway
Journal
Phytomedicine : international journal of phytotherapy and phytopharmacology
The Effect of miR-140-5p with HDAC4 towards Growth and Differentiation Signaling of Chondrocytes in Thiram-Induced Tibial Dyschondroplasia - PMC
Journal
International journal of molecular sciences
Eicosapentaenoic Acid-Induced Autophagy Attenuates Intervertebral Disc Degeneration by Suppressing Endoplasmic Reticulum Stress, Extracellular Matrix Degradation, and Apoptosis
Journal
Front Cell Dev Biol
MicroRNA-155 suppressed cholesterol-induced matrix degradation, pyroptosis and apoptosis by targeting ROR in nucleus pulposus cells
Journal
Cellular signalling
BRD9 Inhibition Attenuates Matrix Degradation and Pyroptosis in Nucleus Pulposus by Modulating the NOX1/ROS/NF-B axis
Application
WB, IF, RT-PCR
Species
Homo sapiens, Rattus norvegicus
Multi-level consistent changes of the ECM pathway identified in a typical keratoconus twin's family by multi-omics analysis
Journal
Orphanet J Rare Dis
Circular RNA CircACAP2 regulates temporomandibular joint osteoarthritis via miR215p/PLAG1 axis
Primary growth plate chondrocyte isolation, culture, and characterization from the modern broiler - PMC
MiR-760 targets HBEGF to control cartilage extracellular matrix degradation in osteoarthritis - PMC
Journal
Journal of orthopaedic surgery and research
Overexpression of miR-148a-3p inhibits extracellular matrix degradation and alleviates IL-1β-induced intervertebral disc degeneration - PMC
Journal
Iranian journal of basic medical sciences
Long non-coding RNA Malat1 is essential for fine-tuning bone homeostasis through orchestrating cellular crosstalk and the -catenin-OPG/Jagged1 pathway - PMC